Evaluation of the Effect of<i>N</i>-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I

Kruh, Jonathan N.; Kruh-Garcia, Nicole A.; Foster, C. Stephen

doi:10.1089/jop.2015.0010

Cited by 7 publications

(4 citation statements)

References 49 publications

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“…Optic zones composed of rigid corneal lens materials may help reduce the amount of surface deposits (hybrid or large diameter rigid lenses) [305]. In a prospective, non-randomised study, the use of topical N-acetylcysteine in conjunction with soft lenses was evaluated and a 20 % decrease in protein deposition was reported when compared to using no agent [307].…”

Section: Over Keratoprosthesismentioning

confidence: 99%

BCLA CLEAR – Medical use of contact lenses

Jacobs

Carrasquillo²,

Cottrell

et al. 2021

Contact Lens and Anterior Eye

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The medical use of contact lenses is a solution for many complex ocular conditions, including high refractive error, irregular astigmatism, primary and secondary corneal ectasia, disfiguring disease, and ocular surface disease. The development of highly oxygen permeable soft and rigid materials has extended the suitability of contact lenses for such applications. There is consistent evidence that bandage soft contact lenses, particularly silicone hydrogel lenses, improve epithelial healing and reduce pain in persistent epithelial defects, after trauma or surgery, and in corneal dystrophies. Drug delivery applications of contact lens hold promise for improving topical therapy. Modern scleral lens practice has achieved great success for both visual rehabilitation and therapeutic applications, including those requiring retention of a tear reservoir or protection from an adverse environment. This report offers a practical and relevant summary of the current evidence for the medical use of contact lenses for all eye care professionals including optometrists, ophthalmologists, opticians, and orthoptists. Topics covered include indications for use in both acute and chronic conditions, lens selection, patient selection, wear and care regimens, and recommended aftercare schedules. Prevention, presentation, and management of complications of medical use are reviewed.

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Section: Over Keratoprosthesismentioning

confidence: 99%

BCLA CLEAR – Medical use of contact lenses

Jacobs

Carrasquillo²,

Cottrell

et al. 2021

Contact Lens and Anterior Eye

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“…We propose that if adequate fit is months, although some practitioners change lenses at longer intervals (3-4 months), as well as shorter intervals in cases of heavy deposits or frequent lens loss. 2,6,12,15,20 During the follow-ups, lenses are either replaced or cleaned and disinfected with commercially available contact lens cleansing solutions and extra-strength cleaners as needed, and observed for adequate fit. 4,6,8 Patients are educated on the need for continuous, lifelong BCL wear and antibiotic prophylaxis, and advised not to remove or handle the lens.…”

Section: Modifying Center Thickness and Utility For Tube Erosionmentioning

confidence: 99%

“…Lens deposits and biofilms may develop and interfere with comfort and vision, as well as increase risk for inflammatory and infectious disease. 4,7,12,[19][20] KPro patients remain at life-long risk of infection, particularly in the presence of high microbial loads on BCLs, and benefit from compliance with medications, good hygiene, periodic povidone-iodine rinses, and routine replacement of contact lenses. 8,12,26…”

Section: Modifying Center Thickness and Utility For Tube Erosionmentioning

confidence: 99%

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Contact Lens Modifications for Boston Keratoprosthesis

Cherny

Sherman

Trief

2022

JCLRS

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Boston Keratoprosthesis Type 1 (KPro), an artificial cornea, is a therapeutic option for patients in need of corneal transplantation when the prognosis of traditional keratoplasty is guarded. Bandage contact lens wear is essential in the post-operative management of KPro eyes in order to maintain adequate corneal graft hydration, and minimize the risk of adverse complications. Suitable bandage contact lens selection is imperative to preserve keratoprosthesis function, and customized modifications of contact lens parameters may be necessary to ensure adequate fitting. The available contact lens options, modifications, and protocols for the continued care of Boston Keratoprosthesis are discussed. A simple, yet unreported modification for contact lenses fit over KPro eyes in the setting of ocular surface irregularities is proposed, which may hold clinical utility when fitting keratoprosthesis patients with scleral elevations and glaucoma filtrationdevices.

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The Clinical Use of N-Acetylcysteine in Other Medical Disorders

Frye

2018

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

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Evaluation of the Effect ofN-Acetylcysteine on Protein Deposition on Contact Lenses in Patients with the Boston Keratoprosthesis Type I

Abstract: NAC reduced protein deposition, decreased ocular surface symptoms, and improved contact lens transparency, thereby providing increased optical clarity.

Cited by 7 publications

References 49 publications

BCLA CLEAR – Medical use of contact lenses

BCLA CLEAR – Medical use of contact lenses

Contact Lens Modifications for Boston Keratoprosthesis

The Clinical Use of N-Acetylcysteine in Other Medical Disorders

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