Evaluation of the effect of ranitidine on gastroduodenal contractile activity and gastric emptying in horses

Maher, Omar; Nieto, Jorge E.; Stanley, Scott D; Doré, Elizabeth; Snyder, Jack R.

doi:10.2460/ajvr.69.9.1153

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…However, in humans, one study failed to find a significant effect of ranitidine on GET [22], while others found that ranitidine decreased GET [23–25]. A recent study failed to find a significant effect of ranitidine on GET in horses [26]. To the authors' knowledge, the effect of ranitidine on GET and other GI transit times in dogs has not previously been reported.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs

Lidbury

Suchodolski

Ivanek

et al. 2012

Veterinary Medicine International

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This study aimed to evaluate the variation associated with repeated measurement of gastrointestinal (GI) transit times and the effect of oral ranitidine on GI transit times in healthy dogs using a wireless motility capsule (WMC) system. Eight privately owned healthy adult dogs were enrolled, and one developed diarrhea and was removed from the study. For the first 3 repetitions, each dog was fed a standard meal followed by oral administration of a WMC. For the 4th repetition, each dog was given ranitidine hydrochloride (75 mg PO every 12 hours) prior to and during assessment of GI transit times. Mean between-subject coefficients of variation for gastric emptying time (GET), small and large bowel transit time (SLBTT), and total transit time (TTT) were 26.9%, 32.3%, and 19.6%, respectively. Mean within-subject coefficients of variation for GET, SLBTT, and TTT were 9.3%, 19.6%, and 15.9%, respectively. Median GET, SLBTT, and TTT without ranitidine were 719, 1,636, and 2,735 minutes, respectively. Median GET, SLBTT, and TTT with ranitidine were 757, 1,227, and 2,083 minutes, respectively. No significant differences in GI transit times were found between any of the 4 repetitions. Under these experimental conditions, no significant effects of oral ranitidine on GI transit times were observed.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs

Lidbury

Suchodolski

Ivanek

et al. 2012

Veterinary Medicine International

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“…Maher et al [25] revealed that ranitidine shows its effects by promoting amplitude responses and does not have any effect on frequency responses. This finding is consistent with our results related to frequency.…”

Section: Discussionmentioning

confidence: 99%

Effects of Proton Pump Inhibitors andH2Receptor Antagonists on the Ileum Motility

Kurt

Altun

Bağcıvan

et al. 2011

Gastroenterology Research and Practice

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Objectives. To investigate the effects of proton pump inhibitors (PPIs) and H2 receptor antagonists on ileum motility in rats with peritonitis and compare changes with control group rats. Methods. Peritonitis was induced by cecal ligation and puncture in 8 rats. Another of 8 rats underwent a sham operation and were accepted as controls. Twenty-four hours later after the operation, the rats were killed, and their ileum smooth muscle was excised and placed in circular muscle direction in a 10 mL organ bath. Changes in amplitude and frequency of contractions were analyzed before and after PPIs and H2 receptor blockers. Results. PPI agents decreased the motility in a dose-dependent manner in ileum in both control and intraabdominal sepsis groups. While famotidine had no significant effect on ileum motility, ranitidine and nizatidine enhanced motility in ileum in both control and intraabdominal sepsis groups. This excitatory effect of H2 receptor antagonists and inhibitor effects of PPIs were significantly high in control group when compared to the peritonitis group. The inhibitor effect of pantoprazole on ileum motility was significantly higher than the other two PPI agents. Conclusions. It was concluded that H2 receptor antagonists may be more effective than PPIs for recovering the bowel motility in the intraabdominal sepsis situation.

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Section: Diseases Associated With Decreased or Abnormal Intestinal Momentioning

confidence: 99%

“…Additionally, ranitidine and nizatidine may stimulate gastric and colonic motility via anticholinesterase activity. In vitro, ranitidine increased pyloric antrum smooth muscle contraction in isolated equine muscle strips (Maher et al 2008). However, there was no difference in liquid phase gastric emptying or frequency of defaecation in healthy horses following a single dose of ranitidine (2.2 mg/kg bwt i.v.)…”

Section: Other Prokinetic Drugsmentioning

confidence: 99%

Motility of the equine gastrointestinal tract: Physiology and pharmacotherapy

Wong

Davis

White

2011

Equine Veterinary Education

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Summary Normal gastrointestinal (GI) motility patterns are necessary to maintain transit of ingesta and to facilitate digestion and absorption of nutrients. Disorders of the equine GI tract are frequently encountered by the equine practitioner and these disorders are often associated with an interruption in normal intestinal motility patterns, thus complicating treatment of the primary disease. Consequently, numerous treatments have been investigated in horses to facilitate the return of normal intestinal motility. The purpose of this article is to provide a brief review of the anatomy and physiology of the GI tract in the horse and review medications available to the equine veterinarian that may potentially promote intestinal motility.

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Evaluation of the effect of ranitidine on gastroduodenal contractile activity and gastric emptying in horses

Abstract: Ranitidine did increase gastric motility in vitro, but no effect on liquid phase gastric emptying was identified in healthy horses by use of the acetaminophen absorption model. Results do not support the use of ranitidine to promote gastric emptying.

Cited by 6 publications

References 30 publications

Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs

Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs

Effects of Proton Pump Inhibitors andH2Receptor Antagonists on the Ileum Motility

Motility of the equine gastrointestinal tract: Physiology and pharmacotherapy

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