Evaluation of the Effect of Topical Heparin on the Treatment of Facial Burn

Hamza, Fawzy Ahmed; Salim, Ahmed Abu-Elsoud; Rizk, Hossam Nasr

doi:10.21608/aimj.2020.23508.1130

Cited by 3 publications

(6 citation statements)

References 6 publications

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“…Result of this study showed that analgesic requirement was lower in patients treated with topical heparin (11.83 ± 9.38 per patient against 33.35 ± 20.63 for the conventional dressing, p<0.01), and has low VAS score for pain. 9 There was statistically significant difference for heparin group both for pain relief and epithelialization.…”

Section: Discussionmentioning

confidence: 87%

Comparison of heparin dressing and conventional dressing in second degree burn patients in term of pain relief and wound healing.

Alam¹,

Mujahid

Khan

2022

TPMJ

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Objective: To compare effectiveness of heparin soaked and conventional dressing in Second degree burn patients. Study Design: Randomized Controlled study. Setting: Department of Burn and Plastic Surgery, Teaching Hospital/DG Khan Medical College. Period: November 2019 to October 2020. Methodology: One hundred twenty patients fulfilling inclusion criteria were enrolled and randomly divided into two groups. Group A (60 patients) were treated with Heparin soaked Dressing and Group B (60 patients) with conventional dressing (Silver Sulphadiazine ointment 1%) and were observed up to 3-weeks of post treatment. Outcome measures were noted and was assessed by Visual Analogue scale score for pain relief and complete re-epithelization of wound (>75%) in the two groups. Significance was determined by comparing analgesia doses and total days required to heal in each dressing using chi-square test. Results: One hundred twenty patients were selected with mean age of patients was 14.4+_7.4 and male: female (62.5%:37.5%). Mean TBSA% was 12±1.80. Mean pain score in the group A for Superficial partial thickness burn (SPTB) and Deep dermal burn was 4±1 and 6±1 respectively (P-value <0.001). Total Number of days for re-epithelization in the Group A and Group B (SPTB 13±1 vs. 18 measures in term of pain relief and re-epithelization. Total analgesia requirement in the Group A and Group B (50±20 vs. 116±12mg; P-value <0.000 for Superficial Partial Thickness burn and 46±6 vs. 126±12mg; P-value <0.001 for Deep partial thickness burn) respectively. There was significant difference in Outcome. Conclusion: Heparin soaked dressing is more useful and effective in Second degree burn in term of pain relief and re-epithelization in early post burn period compared to the conventional dressing.

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Section: Discussionmentioning

confidence: 87%

Comparison of heparin dressing and conventional dressing in second degree burn patients in term of pain relief and wound healing.

Alam¹,

Mujahid

Khan

2022

TPMJ

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“…On the contrary, the majority of Fawzy et al, patients were adults who could express and evaluate pain more precisely. The use of analgesics is not a valid factor in our study as the patients had both products at the same wound [9].…”

Section: Discussionmentioning

confidence: 97%

“…There are studies that compare the effect of topical anticoagulants to the other agents used in treatment of burns [9]. Fawzy et al, is one of these studies as it used topical heparin dressing compared to antimicrobi-al agent for superficial, partial and full thickness burns of face [9]. Fawzy et al, study showed that heparin solution treated patients showed significant less pain, through both VAS and analgesic use [9].…”

Section: Introductionmentioning

confidence: 99%

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Comparison between Topical Beta-Sitosterol and Topical Hirudin in Management of Facial Burns

Mohamed,

Abolnaga,

Moghazy

et al. 2024

The Egyptian Journal of Plastic and Reconstructive Surgery

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Background: Facial burns are challenging, as the aesthetic outcome is as important as the functional. Topical interventions are currently the cornerstone of treatment of facial burns. Although there is no gold standard agent for the treatment of facial burns, beta-sitosterol is the most commonly used as first line agent.Recombinant hirudin is an agent derived from medicinal leech and it has anti-thrombotic action, which is thought to have effect on facial burns healing.Objective: The objective of this study is to compare the effect of beta-sitosterol and hirudin in the management of facial burns regarding the pain, edema, healing time, and aesthetic outcome. Patients and Methods:A concurrent self-control open label clinical trial was conducted on fifteen patients attending the burn unit at Suez Canal University Hospital with facial burns. Visual Analogue Scale for pain to time, edema, hospitalization time, healing time, scarring by the patient and observer scar assessment scale (POSAS) and final aesthetic outcome.Expected Outcome: In patients with facial burns, the use of topical hirudin will reduce pain and edema; enhance faster healing and less hospitalization time, less scarring and better final aesthetic outcome. Conclusion:Topical hirudin use in facial burns is a safe and effective option as it showed statistically significant results regarding wound healing and final scar quality outcome that was better than topical beta-sitosterols. Although its effects regarding pain and edema showed no statically significant difference in comparison to topical beta-sitosterols, it should be considered as an effective safe option in the treatment of facial burns.

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“…Another reason is the moisturizing effect of heparin. Heparin is a polysaccharide that can adsorb water and is suggested to have highly moisturizing properties. , Heparin also has good analgesic and anti-inflammatory effects, and its moisturizing effect can restore skin moisture . A third possible reason is the effect of GFs’ on wound healing.…”

Section: Discussionmentioning

confidence: 99%

Prevention and Repair of Ultraviolet B-Induced Skin Damage in Hairless Mice via Transdermal Delivery of Growth Factors Immobilized in a Gel-in-Oil Nanoemulsion

et al. 2023

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Ultraviolet (UV) radiation from the sun or artificial sources is one of the primary causes of skin damage, including sunburns, tanning, erythema, and skin cancer. Among the three different types of UV rays, UVB rays have a medium wavelength that can penetrate the epidermal layer of the skin, resulting in sunburn, suntan, blistering, and melanoma in case of chronic exposure. This study aimed to evaluate the preventive and therapeutic effects of a gel-in-oil nanogel dispersion (G/O-NGD) as a transdermal delivery biomolecular carrier for skin damage caused by UVB light. The efficacy of this carrier against UVBinduced skin damage was investigated in vivo by delivering different growth factors (GFs) encapsulated in a G/O-NGD. Artificial UVB light was used to induce skin damage in nude mice, followed by the transdermal application of five GF [vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), transforming growth factor (TGF)-1, and insulin-like growth factor (IGF)-α]-immobilized G/O-NGD. Among these GFs, VEGF and bFGF promoted angiogenesis, while EGF, TGF-1, and IGF-α promoted the repair and regeneration of damaged cells. The results showed that G/O-NGD was superior to heparin-immobilized G/O-NGD in reducing UVB-induced skin damage, such as erythema, epidermal water reduction, inflammation, and dermis thickening. In addition, G/O-NGD could prevent and treat abnormal follicle proliferation caused by UVB rays and exhibited potential to repair lipid glands. Overall, our results demonstrate the potential of G/O-NGDs for the treatment of UVB-induced skin damage.

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Evaluation of the Effect of Topical Heparin on the Treatment of Facial Burn

Cited by 3 publications

References 6 publications

Comparison of heparin dressing and conventional dressing in second degree burn patients in term of pain relief and wound healing.

Comparison of heparin dressing and conventional dressing in second degree burn patients in term of pain relief and wound healing.

Comparison between Topical Beta-Sitosterol and Topical Hirudin in Management of Facial Burns

Prevention and Repair of Ultraviolet B-Induced Skin Damage in Hairless Mice via Transdermal Delivery of Growth Factors Immobilized in a Gel-in-Oil Nanoemulsion

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