Evaluation of the Effect of Magnesium Sulphate vs. Clonidine as an Adjuvant to Epidural Levobupivacaine in Patients Undergoing Lower Abdominal Surgeries- A Prospective,randomised and Double-Blinded Study

Abstract

BACKGROUNDVarious adjuvants can be added to local anaesthetics and administered in central neuraxial blockade to improve the speed of onset, quality and duration of analgesia with desirable sedation. Magnesium Sulphate and Clonidine are relatively harmless molecules, cost-effective and biological basis for their anti-nociception is promising. Therefore, in this study, Magnesium Sulphate was compared with Clonidine (α2-agonist) as adjuvant to Levobupivacaine in epidural anaesthesia.The aim of the study is to compare the effects of Magnesium Sulphate (50 mg) Vs. Clonidine (150 mcg) as an adjuvant to Epidural 0.5% Levobupivacaine in adult patients undergoing lower abdominal surgeries in a prospective, randomised and doubleblinded study.