Evaluation of the effect of Retrograde Intrarenal Surgery with Myo-Inositol Oxygenase

Abstract

Objective:To investigate the effect of retrograde intra-renal surgery (RIRS) on kidneys using the myo-inositol oxygenase (MIOX) enzyme. MIOX is a renal tubular-specific novel marker for the early diagnosis of acute kidney injury.Methods:A total of twenty seven individuals that had undergone RIRS to treat kidney stones were included in the study. Biochemical tests were performed on serum samples collected immediately before RIRS (hour 0) and at the 6th and 24th hours after the surgery.Results:The creatinine value at hour 6 was lower than the baseline (hour 0) value (p = 0.0305). Cystatin C at hour 6 was lower than the value measured at hour 24 (p = 0.0142). Similarly, MIOX was lower at hour 6 compared to hour 24 (p = 0.0214). MIOX/creatinine at hour 6 was lower than the value calculated at hour 24 (p = 0.0348). The basal values of MIOX and creatinine were found to have a positive correlation (correlation coefficient r = 0.5946, p = 0.0035).Conclusions:Similar to the serum creatinine, the serum MIOX level provides information about kidney functions. RIRS was confirmed to be a safe procedure for the treatment of acute kidney injury with no negative effects on the kidneys.

Effectiveness of myo-inositol oxygenase in the early diagnosis of experimental acute kidney injury

“…In another study, in which we investigated the effect of retrograde intrarenal surgery on kidney tissue in renal stone treatment, the serum MIOX level was found to be benefi cial in showing renal damage. Moreover, there was a positive correlation between the levels of serum MIOX and creatinine in the same study (11).…”

“…This is a unique pathway for MI catabolism (7)(8)(9). Although the MIOX enzyme is one of rare organ-specifi c enzymes, particularly a renal-specifi c enzyme, the data on the role of MIOX in the diagnosis of AKI are limited (9)(10)(11).…”

All-Seeing-Access Sheath: A Novel Fluoroscopy-Free Placement Technique in Retrograde Intrarenal Surgery

“…1 This less invasive method is comparable with the other well known treatment techniques (percutaneous nephrolithotomy and open surgery), and high success were reported with low complication rates. [2][3][4][5] As this tecnique has become widespread, several potential risks of radiation including cancer, and genetic mutations because of the use of fluoroscopy, should be discussed. Recent studies have aimed to use fluoroscopy at a minimal level to avoid damage to the healthcare staff and the patient in RIRS; but as the number of operations are rapidly increasing the cumulative doses of radiation is becoming a more important issue.…”

Are endourological procedures for nephrolithiasis treatment associated with renal injury? A review of potential mechanisms and novel diagnostic indexes

“…Only six studies were found to investigate the effect of endourological procedures on renal function by using urine ( n = 5) or serum ( n = 1) biomarkers for early diagnosis of AKI [ 3–5 , 51–53 ], while only two of them used modern definition criteria of AKI [ 4 , 53 ]. The basic characteristics of these studies are presented in Table 4 .…”

“…Recently, Mertoglu et al [ 53 ] investigated, in a single-arm, open-label, prospective study including 27 patients, the effect of RIRS on renal function using serum myo-inositol oxygenase (MIOX) enzyme and cystatin C. MIOX is a renal tubular–specific novel biomarker used for the early diagnosis of AKI. Serum samples of MIOX, cystatin C and Cr levels were measured before RIRS and 6 and 24 h post-operatively.…”