EVALUATION OF THE EFFECT OF FLAVONOID EXTRACT OF Ginkgo biloba LEAVES AND GLIMEPHAN ON OXIDATIVE STRESS AND RETINA DEGENERATION IN DIABETIC MALE RABBITS INDUCED BY STREPTOZOTOCIN

Abstract

This study was carried out in animal house of Collage of Veterinary Medicine/ University of Basrah. An attempt has been done to induce diabetic by streptozotocin in male rabbits and investigation of the diabetes was induced oxidative stress and retina degeneration. Moreover, the purpose of this study was to isolate and evaluate the ameliorating effect of flavonoid extract of Ginkgo biloba leaves and glimephan in the prophylaxes or delay the development of diabetic retina degeneration and scavenging free radical induced oxidative stress and diabetic retina degeneration in male rabbits.The study was done on (32) adult male rabbits, their weight ranged between (2000-2500g) and aged between 7-8 months. The male rabbits were divided randomly into four groups, each group consists of eight rabbits as the following: Group1:-Male rabbits at (Negative controls(-ve)) administrated normal saline1ml orally for 30 days.Group2:-Male rabbits at(Positive control(+ve)) were given streptozotocin (65mg/kg B.W. dissolve in sodium citrate I.V.) for two days and remain for 30 days.

Medical Ozone Treatment Alleviate Blood Oxidative Stress And Pancreas Damage In an Alloxan-Induced Diabetes Model in Rats

“…Ozone therapy may be considered as an adjuvant to insulin in the treatment of diabetes to prevent or alleviate diabetes induced complication [27]. loss of body weight have been associated with diabetes mellitus [31,32]. Alloxan induced diabetes significantly decreases body weight of the diabetic untreated rat as the study duration increase compared with the diabetic treated and control rats.…”