Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study

Lektemur Alpan, Aysan; Torumtay Cin, Gizem; Kızıldağ, Alper; Zavrak, Necati; Özmen, Özlem; Arslan, Şevki; Mutlu, Doğukan

doi:10.1080/08977194.2023.2289375

Cited by 4 publications

(3 citation statements)

References 49 publications

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“…PDGF stimulates cellular proliferation in fibroblasts and smooth muscle cells, while TGF-β regulates collagen and proteoglycan synthesis to facilitate cartilage formation. VEGF promotes angiogenesis to improve blood supply and nutrition to joint tissues [ 13 , 14 , 32 ]. Together, these elements initiate tissue repair by reducing inflammation, encouraging cartilage regeneration, and improving vascularity.…”

Section: Discussionmentioning

confidence: 99%

“…The motivation for using autologous blood products stems from their abundant supply of growth factors and cytokines, such as Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor-β (TGF-β), and Vascular Endothelial Growth Factor (VEGF). These components are crucial in modulating inflammatory responses, enhancing tissue regeneration, and accelerating the healing process through the stimulation of cell proliferation and migration, promotion of angiogenesis, and facilitation of matrix synthesis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…The use of PRF, a second-generation platelet concentrate, is advantageous due to its ease of application and enhanced tissue penetration, especially in its liquid form (liquid PRF or i-PRF). The sustained release of growth factors and cytokines at the injury site not only aids in the quick resolution of inflammatory responses but also enhances the overall regeneration of damaged tissues [ 13 , 14 ]. This highlights the potential of liquid PRF/i-PRF as a biologically potent treatment option for TMDs, paving the way for investigating the clinical efficacy of liquid PRF in TMD management.…”

Section: Introductionmentioning

confidence: 99%

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Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials

Nemeth,

Gurgel,

Lowenstein

et al. 2024

Bioengineering

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Temporomandibular joint disorders (TMDs) are prevalent musculoskeletal conditions involving pain and dysfunction of jaw mobility and function, which have proven difficult to treat satisfactorily. The present study aimed to assess the effectiveness of a liquid platelet-rich fibrin (i-PRF) infusion during arthrocentesis versus other options using coadjuvant materials to reduce TMD symptoms. A literature search was conducted using PubMed, EMBASE, Web of Science, Scopus, and ClinicalTrials.gov for RCTs published before January 2024, comparing i-PRF to any other TMD treatment. This systematic review was registered on PROSPERO (CRD42023495364). The searches generated several recent RCTs that compared i-PRF injection combined with arthrocentesis (AC) to AC-only or AC with platelet-rich plasma (PRP). The outcomes analyzed included measures of pain (visual analog scale, VAS), maximum mouth opening, joint sounds, and MRI-verified changes in joint structure. Across the RCTs, the addition of i-PRF injection to AC resulted in significant improvements in pain relief, joint function, mouth opening, and structural changes compared to AC-only or with PRP over follow-up periods ranging from 6 to 12 months. Current clinical evidence favors using i-PRF as an adjunct to AC rather than AC-only or AC with PRP for the treatment of TMDs. The improvements in subjective and objective outcome measures are clinically meaningful. Still, additional high-quality RCTs with larger sample sizes and longer follow-ups are required to strengthen the evidence base and better define the role of i-PRF in TMD management guidelines.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials

Nemeth,

Gurgel,

Lowenstein

et al. 2024

Bioengineering

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Effects of Different Electrospinning Methods with i-PRF on the Differentiation of Tendon Stem Cells

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2024

ACM

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The additive value of platelet-rich plasma to topical Minoxidil in the treatment of androgenetic alopecia: A systematic review and meta-analysis

Yao,

Zhu,

Pan

et al. 2024

PLoS ONE

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Objective It still needs to be determined if platelet-rich plasma (PRP) has any added advantage over Minoxidil in treating androgenetic alopecia. We reviewed randomized controlled trials (RCTs) comparing scalp injections of PRP plus Minoxidil vs Minoxidil alone for managing androgenetic alopecia. Methods All RCTs published on Embase, Cochrane Library, and PubMed comparing PRP plus Minoxidil vs. Minoxidil alone were eligible. The literature search was completed on 5 March 2024. The review was registered on PROSPERO (CRD42024509826). Results Of five included RCTs, three had a high risk of bias, while one had some concerns. A systematic review of the studies showed that all trials reported better outcomes with PRP plus Minoxidil than with Minoxidil alone. Meta-analysis showed that hair density at one month (MD: 11.07 95% CI: 1.20, 20.94 I2 = 0%), three months (MD: 21.81 95% CI: 10.64, 33.00 I2 = 57%) and 5/6 months (MD: 17.80 95% CI: 7.91, 27.69 I2 = 80%) of follow-up was significantly better in the PRP plus Minoxidil vs the Minoxidil alone group. Meta-analysis of adverse events showed that the risk of adverse events was comparable in both groups (OR: 0.55 95% CI: 0.22, 1.36 I2 = 0%). The certainty of evidence on the GRADE assessment was "low to very low." Conclusion Very low-quality evidence shows that the addition of injectable PRP to topical Minoxidil may improve outcomes in patients with androgenetic alopecia. The addition of PRP was found to improve hair density and patient satisfaction significantly. However, the small number of studies with a high risk of bias and heterogeneity in PRP preparation methods are significant limitations of current evidence. Further studies with larger sample sizes and uniform PRP preparation protocols are needed.

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Evaluation of the effect of injectable platelet-rich fibrin (i-PRF) in wound healing and growth factor release in rats: a split-mouth study

Cited by 4 publications

References 49 publications

Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials

Does Liquid/Injectable Platelet-Rich Fibrin Help in the Arthrocentesis Treatment of Temporomandibular Joint Disorder Compared to Other Infusion Options? A Systematic Review of Randomized Clinical Trials

Effects of Different Electrospinning Methods with i-PRF on the Differentiation of Tendon Stem Cells

The additive value of platelet-rich plasma to topical Minoxidil in the treatment of androgenetic alopecia: A systematic review and meta-analysis

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