Evaluation of the Effect of Hydroalcoholic Extract of Zingiber officinale Rhizomes in Rat Collagen‐induced Arthritis

Abstract

Patients with chronic, painful diseases often seek alternative therapy. The purpose of this study was to investigate the potential of hydroalcoholic extract of Zingiber officinale rhizomes ( Z. officinale extract) to ameliorate inflammatory process in rat collagen-induced arthritis. Our results show that Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally starting from the dose of booster immunization and for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction, together with reduction of serum levels of interleukin (IL)-1 β , IL-2, IL-6, tumour necrosis factor-α , and anti-CII antibodies. Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior to 2 mg/kg/day of indomethacin at most of the measured parameters. These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis.

In vitroantimicrobial and anti-endotoxin action ofZingiber Officinaleas auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine

“…Although the mechanism of action of ginger extract on micro-organisms is not be elucidated in the literature, studies reveal effective antimicrobial action of this extract on the microorganisms [14]. Other investigations further demonstrated that ginger is biocompatible, being used also in the diet [28,29]. However, there are no studies on the effects of active principles of ginger.…”

Pharmacological Basis for the Medicinal Use of Psyllium Husk (Ispaghula) in Constipation and Diarrhea

“…A specimen, voucher # Po-SH-09-06-81, was preserved in the herbarium of the Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University, Karachi. By following a previously described method [30] with slight modification, psyllium husk was soaked in 70% methanol for three days and filtered through muslin cloth and Whatman (Maidstone, UK) no. 1 filter paper, simultaneously.…”

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

“…(9) Hydroalcoholic extract of Zingiber officinale rhizomes (Ginger extract) showed an antiarthritic effect as tested in the rat CIA model. Ginger extract ameliorated the clinical scores, disease incidence, joint swelling, expression of IL-1 β , IL-2, IL-6, and TNF- α , and cartilage destruction [127]. (10) Root extract from Astragalus ( Radix astragali ) reduced cellular accumulation, swelling and arthritic index of the joints, as well as serum levels of TNF- α and IL-1 β in rats with AA [12].…”