Evaluation of the Early Prognostic Value of Neutrophil-Lymphocyte Ratio (Nlr) and Platelet-Lymphocyte Ratio (Plr) in Snakebite Poisoned Patients

Elawady, Eglal; Tawfik, Hany

doi:10.21608/ejfsat.2016.41636

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

2019

DOI: 10.21608/ejfsat.2016.41636

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Evaluation of the Early Prognostic Value of Neutrophil-Lymphocyte Ratio (Nlr) and Platelet-Lymphocyte Ratio (Plr) in Snakebite Poisoned Patients

Eglal Elawady

Hany Tawfik

Abstract: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have recently gained popularity as simple, inexpensive, and highly accurate inflammatory markers and they have been suggested as useful predictors for clinical prognosis in critically ill patients in various medical conditions. This study aimed to assess the usefulness of NLR and PLR in predicting the severity of clinical profile and outcome in patients with snake poisoning. Methods: a prospective study

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Cited by 3 publications

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Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite

Abd El-Azim,

Mousa,

Abdelmaaboud

et al. 2023

Biomarkers

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Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite

Abd El-Azim,

Mousa,

Abdelmaaboud

et al. 2023

Biomarkers

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Role of neutrophil–lymphocyte ratio in the management of children with snake bite envenomation: A single-center prospective observational study

Vijayaragavan,

Balasubramanian,

Venkataramanan

et al. 2024

Journal of Pediatric Critical Care

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Background: Neutrophil–lymphocyte ratio (NLR) has recently gained popularity as a simple, inexpensive, and highly accurate inflammatory marker. When the differential count of leukocytes is checked following it is characterized by leukocytosis with an increase in neutrophil count and a decline in lymphocyte counts. This study was conducted to assess whether alteration in the differential count of leukocytes following envenomation has the ability to diagnose and predict the severity and prognosis in children and to derive a cutoff value for the same. Subjects and Methods: This prospective observational study was done in the pediatric intensive care unit (ICU) of a tertiary care hospital from July 2019 to June 2020. From the complete blood count of patients done at admission, NLR1 was calculated. All patients were treated as per the national snake bite treatment protocol. The amount of antisnake venom (ASV) given, duration of hospital stay, and ICU stay were correlated with NLR1 values. Results: An NLR value of 3.35 can predict envenomation with 95% sensitivity and 100% specificity. Similarly, an NLR value of 6.72 can predict the need for more than 10 ASV vials with a sensitivity of 93% and specificity of 97%, and an NLR value of 6.72 can predict the occurrence of major complications with a sensitivity of 89.3% and specificity of 94%. Conclusions: NLR can differentiate poisonous snake bites from nonpoisonous bites and can also predict the severity of the envenomation.

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Çocuk Acil Servise Zehirlenme İle Başvuran Hastaların Sosyodemografik ve Laboratuvar Verilerinin İncelenmesi

Arsoy

Güneysu

2021

Eurasian Journal of Toxicology

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Objective: To keep up-to-date and enlighten the demographic characteristics of children admitted to the emergency department with poisoning and the treatment strategies of physicians, to examine laboratory parameters, and to ensure rapid and effective interventions. Materials and Methods:Patients aged 0-18 years who were admitted to the Sakarya Training and Research Hospital Pediatric Emergency Service for 24 months in 2018-2020 for accidental or suicidal poisoning were included in our study. Age, gender, location of the cases at the time of poisoning, first intervention by the family, if any, how long after the poisoning, the substance causing the poisoning, the route of poisoning, the accidental / deliberate exposure, the use of antidote or active charcoal condition, need for hospitalization or intensive care, duration of hospital stay, presence of mortality and morbidity, and some laboratory data were recorded. The relationship between inflammatory parameters and variables was also investigated.Results: It was determined that 74 girls (23.0%) and 5 boys (1.7%) committed suicide, 235 girls (74.6%) and 266 boys (90.6%) were accidentally poisoned. A statistically significant relationship was found between the purpose of poisoning and hospitalization day classes (χ2 = 13.776; p = 0.008). A weakly significant correlation was found between AST, ALT, WBC, lymphocyte, platelet, CRP, INR values, the AST and INR values were higher in mouse poisoning but not statistically significant (p> 0.05), WBC value in poisoning with cleaning materials It was found that it was significantly high (p <0.05), and it was significant in caustic corrosive substance intoxications (p <0.05). The CRP value is not significantly different (p> 0.05). Neutrophil / lymphocyte ratio (NLR) increases with age (p <0.05) and increases significantly in patients who come to the hospital late (p <0.05). Conclusion:As first intervention is very important in patients who come to the emergency, it is very important to seek consultation from other branches such as pediatric surgery and child psychiatry. Blood tests performed from patients who come to the emergency room can give information about the status of poisoning and prognosis. Troponin I level can be supportive in terms of treatment plan in carbon monoxide poisoning. In particular, inflammatory parameters and neutrophil / lymphocyte ratio are among the parameters that must be evaluated.

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Evaluation of the Early Prognostic Value of Neutrophil-Lymphocyte Ratio (Nlr) and Platelet-Lymphocyte Ratio (Plr) in Snakebite Poisoned Patients

Cited by 3 publications

References 40 publications

Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite

Evaluation of the role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) time series as predictors of diagnosis and prognosis of hemotoxic snakebite

Role of neutrophil–lymphocyte ratio in the management of children with snake bite envenomation: A single-center prospective observational study

Çocuk Acil Servise Zehirlenme İle Başvuran Hastaların Sosyodemografik ve Laboratuvar Verilerinin İncelenmesi

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