Evaluation of the distortion of EEG signals caused by a hole in the skull mimicking the fontanel in the skull of human neonates

Flemming, Lars; Wang, Yaozhi; Caprihan, Arvind; Eiselt, M.; Haueisen, Jens; Okada, Yoshio

doi:10.1016/j.clinph.2005.01.007

Cited by 60 publications

(38 citation statements)

References 27 publications

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“…The limitations of existing experiments are that (1) the skull defect was filled with non-conducting air (except in (Flemming et al, 2005) for EEG); (2) the skull defect was large compared with the sensor planes (skull-on versus skull-off); and (3) that evoked responses were used, which have a high variability with regard to source position, extent, orientation, and amplitude. Therefore, the objective of this study is to experimentally investigate the influence of conducting skull defects on EEG and MEG signals above and around a skull defect, using a well-defined current source under the middle and edge of the defect and next to it, in an in vivo rabbit model.…”

Section: Introductionmentioning

confidence: 99%

Magnetoencephalography signals are influenced by skull defects

Lau

Flemming

Haueisen

2014

Clinical Neurophysiology

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Section: Introductionmentioning

confidence: 99%

Magnetoencephalography signals are influenced by skull defects

Lau

Flemming

Haueisen

2014

Clinical Neurophysiology

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“…It detects the extracranial magnetic fields produced by currents generated in the cerebral cortex, and is not affected by the fontanels and sutures of the skull (Flemming et al, 2005). This simplifies the interpretation of MEG signals, compared with EEG, and makes the localization of the active cortical areas more accurate particularly in children (Hämäläinen et al, 1993;Okada et al, 1999).…”

Section: Introductionmentioning

confidence: 98%

Does very premature birth affect the functioning of the somatosensory cortex? — A magnetoencephalography study

Nevalainen

Pihko

Metsäranta

et al. 2008

International Journal of Psychophysiology

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“…[24][25][26] Hence, compared with EEG signals, MEG signals are less likely to be distorted by postoperative skull defects as evidenced by these human and animal studies. [24][25][26] Furthermore, extraoperative IVEEG using subdural electrodes is less effective in detecting recurrent or residual epileptogenic zones after brain surgery. Epileptic discharges of differing amplitudes coexist in the unresected part of the cortex and the cortex affected by the resection, which is covered by gliotic tissues secondary to subdural scarring and arachnoid adhesions.…”

Section: Residual Auditory Aurasmentioning

confidence: 83%

Magnetoencephalographic spike sources associated with auditory auras in paediatric localisation-related epilepsy

Mohamed

Otsubo

Pang

et al. 2006

Journal of Neurology, Neurosurgery & Psychiatry

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Objective: To characterise magnetoencephalographic spike sources in paediatric patients with auditory auras and recurrent localisation-related epilepsy. Methods: Six patients (four boys and two girls (ages 7-14 years) were retrospectively studied. All patients had auditory auras as part of their initial seizure manifestation, including four patients who underwent previous brain surgery. Scalp video electroencephalography and magnetoencephalography (MEG) were carried out in six patients, intraoperative electrocorticography in three patients and extraoperative intracranial video electroencephalography in one patient. MEG auditory-evoked fields (AEFs) were studied in four patients. Results: Three patients had elementary auditory auras, one had complex auditory aura and two had both complex and elementary auras. All six patients had clustered MEG spike sources with coexisting scattered spike sources. MEG clusters were localised in the superior temporal gyrus with surrounding scatters in four patients (two left and two right); two patients had scattered spikes in the superior temporal gyrus in addition to clustered MEG spike sources in the left inferior and middle frontal gyri or parieto-occipital region. AEFs were located within an MEG cluster in one patient and within 3 cm of a cluster in two patients. Surgical resection, including the regions of MEG clusters, was carried out in four patients. Three of four patients who had previous surgeries were seizure free at 2 years after excision of the MEG cluster region. Conclusions: MEG spike sources clustered in the superior temporal gyrus in six patients with auditory auras. These spike sources were in close proximity or seemed to engulf the magnetic AEF. Areas with MEG spike sources contained the residual or recurrent epileptogenic zone after incomplete cortical excision for lesional epilepsy.

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Evaluation of the distortion of EEG signals caused by a hole in the skull mimicking the fontanel in the skull of human neonates

Cited by 60 publications

References 27 publications

Magnetoencephalography signals are influenced by skull defects

Magnetoencephalography signals are influenced by skull defects

Does very premature birth affect the functioning of the somatosensory cortex? — A magnetoencephalography study

Magnetoencephalographic spike sources associated with auditory auras in paediatric localisation-related epilepsy

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