Evaluation of the direct effects on retinal and choroidal microvascularity of systemic scleroderma

Kök, Mehmet; Ayan, Ayşe; Küçük, Mehmet Fatih; Erol, Muhammet Kazım; Yaprak, Lütfiye

doi:10.1016/j.mvr.2021.104166

Cited by 12 publications

(15 citation statements)

References 28 publications

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“…The posterior eye is one of the tissues in the body that has the highest metabolic activity. As a consequence, it is exceedingly vulnerable to capillary injury [ 30 , 31 ]. Once the vasculopathy happened in the retina, the pathology of the retinal region will also be changed, which might affect the whole choroidal and retinal vascular network.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis

Fang

Peng

et al. 2023

BioMed Research International

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In this study, we aim to investigate retinal thickness (RT) and superficial vascular density (SVD) differences between patients with systemic sclerosis (SSc) and healthy controls (HCs) by optical coherence tomography angiography (OCTA). Sixteen patients with a definitive SSc diagnosis without clinical signs of retinopathy and 16 normal control subjects were recruited. All individuals underwent OCTA scanning to assess macular RT and SVD. We divided each image into nine subregions as the early treatment diabetic retinopathy study (ETDRS). Visual acuity (VA) was considerably different between patients with SSc (32 eyes) and control subjects (32 eyes) ( p < 0.001 ). Compared to the control group, individuals with SSc had decreased inner RT in inner superior, outer superior, outer temporal, inner temporal, center, and inner nasal regions ( p < 0.05 ). Outer RT was decreased in the outer and inner temporal regions, and full RT was decreased in the regions of outer superior, inner superior, inner temporal, and outer temporal, in comparison to the control group ( p < 0.05 ). Patients with SSc had significant reduction of SVD in the inner and outer of both superior and temporal, besides outer nasal regions than controls. ( p < 0.05 ). Moreover, SVD was significantly associated with the outer temporal region of patients suffering from SSc ( p < 0.05 ). Diagnostic Sensitivity of RT and SVD of Inner Superior Regions in SSc, as indicated by areas under curves of the Receiver Operating Characteristic (ROC), were 0.874 (95% CI: 0.786–0.962) and 0.827 (95% CI: 0.704–0.950), respectively. In conclusion, VA may be affected by RT variations inside the macula in patients with SSc. Measuring RT with OCTA could be a useful predictor of early diagnosis.

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Section: Discussionmentioning

confidence: 99%

[Retracted] The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis

Fang

Peng

et al. 2023

BioMed Research International

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“…Nailfold capillaroscopic changes are extensively described and investigated in several rheumatic diseases such as systemic sclerosis, SLE, and dermatomyositis [11][12][13][14]. Interestingly, in literature, ocular manifestations, including abnormalities in the microcirculation of the retina and choroid, are described in these rheumatic diseases [44][45][46][47][48][49][50]. Several of these studies use optical coherence tomography angiography (OCT-A) as a noninvasive tool to assess the retinal and choroidal microcirculation [44,45,47,49,50].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, in literature, ocular manifestations, including abnormalities in the microcirculation of the retina and choroid, are described in these rheumatic diseases [44][45][46][47][48][49][50]. Several of these studies use optical coherence tomography angiography (OCT-A) as a noninvasive tool to assess the retinal and choroidal microcirculation [44,45,47,49,50]. Jakhar et al revealed that patients with systemic sclerosis with retinal disease have more severe NFC changes [51].…”

Section: Discussionmentioning

confidence: 99%

Involvement of the systemic microcirculation in pediatric uveitis

Kouwenberg,

Spierings,

de Groot

et al. 2023

Pediatr Rheumatol

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Background Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in intermediate uveitis and panuveitis. Here, we examined the extraocular (i.e., systemic) microcirculation in pediatric uveitis cases and healthy controls using nailfold capillaroscopy (NFC). Methods We performed NFC in 119 children with noninfectious uveitis and 25 healthy pediatric controls, and assessed the following parameters: capillary density (number of capillaries/mm), dilated capillaries (apex > 20 µm), avascular area, the presence of microhemorrhages, and capillary morphology. Differences in NFC parameters between cases and controls were calculated using regression analysis after adjusting for age and sex. Results The mean (± SD) age of the patient group was 13.7 (± 3) years, with 56% females; 46%, 18%, and 36% of cases presented as anterior uveitis, intermediate uveitis, and panuveitis, respectively, with an overall mean disease duration of 4.7 (± 4.0) years. Compared to the control group, the pediatric uveitis cases had a significantly higher number of dilated capillaries/mm and a higher prevalence of ramified capillaries. Moreover, compared to the control group the intermediate uveitis cases had a significantly higher number of dilated capillaries, whereas the anterior uveitis cases had a lower capillary density and a higher prevalence of ramified capillaries. Conclusions Children with uveitis without systemic disease can present with changes in systemic microcirculation. These changes vary amongst the subtypes of uveitis.

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“…Abdellatief et al reported ICGA finding of choroidal vessel leakage in both eyes of a patient with SSc [141]. While Aydın et al [142] did not find a significant difference in CT of SSc patients, several other studies showed a significantly thinner choroid in patients with SSc than in healthy controls [137,[143][144][145][146]. Ingegnoli et al have reported a decrease in choroidal and macular thickness, as well as in ganglion cell complex in patients with primary Raynaud's phenomenon (RP) [143].…”

Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 99%

“…As OCTA is effective in evaluating choriocapillaris density, but not the Haller and Sattler's layers, they assumed that the decrease in CT was mainly caused by these two layers [146].…”

Section: Vasculitis Associated With Systemic Diseasementioning

confidence: 99%

Choroidal involvement in systemic vasculitis: a systematic review

Özdal

Tuğal-Tutkun

2022

J Ophthal Inflamm Infect

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Systemic vasculitides are a large group of heterogeneous diseases characterized by inflammatory destruction of blood vessels targeting diverse organs and tissues including the eye. As the most vascularized layer of the eye, the choroid is expected to be affected in multiple systemic rheumatologic diseases with vascular involvement. While there are plenty of studies investigating retinal vascular involvement, choroidal vascular involvement in systemic vasculitides has not been investigated in isolation. However, choroidal manifestations including thickness changes, choroidal vasculitis and ischemia may be the earliest diagnostic features of systemic vasculitic diseases. Thus, multimodal imaging of the choroid may help early detection of choroidal involvement which may also have prognostic implications in these life-threatening diseases. This article aimed to review involvement of the choroid in systemic vasculitic diseases.

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Evaluation of the direct effects on retinal and choroidal microvascularity of systemic scleroderma

Cited by 12 publications

References 28 publications

[Retracted] The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis

[Retracted] The Function of Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Sclerosis

Involvement of the systemic microcirculation in pediatric uveitis

Choroidal involvement in systemic vasculitis: a systematic review

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