Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation

Jannin, Vincent; Blas, Lucia; Chevrier, Stéphanie; Miolane, Cédric; Demarne, Frédéric; Spitzer, Denis

doi:10.1016/j.ejps.2017.09.049

Cited by 20 publications

(9 citation statements)

References 15 publications

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“…High-speed stirring was performed at 10,000 rpm for 2–6 min followed by constant stirring at 1600 rpm for 1–4 h to produce SLNs with a PS of 68 nm and a PDI of 0.149 [ 73 ]. Both high-speed stirring and ultra-sonication are easy to handle and can be used widely without organic solvents [ 74 ]. However, both suffer from the disadvantage that drugs are exposed to high temperatures for extended times [ 75 ].…”

Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

2020

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Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. The methods used to produce SLNs and NLCs have been well investigated and reviewed, but solvent injection method provides an alternative means of preparing these drug carriers. The advantages of solvent injection method include a fast production process, easiness of handling, and applicability in many laboratories without requirement of complicated instruments. The effects of formulations and process parameters of this method on the characteristics of the produced SLNs and NLCs have been investigated in several studies. This review describes the methods currently used to prepare SLNs and NLCs with focus on solvent injection method. We summarize recent development in SLNs and NLCs production using this technique. In addition, the effects of solvent injection process parameters on SLNs and NLCs characteristics are discussed.

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Section: Methods For Slns and Nlcs Preparationmentioning

confidence: 99%

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

2020

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“…Their size ranges from 50-1000 nm and are dispersed in aqueous surfactant solution [69]. Lipids used in the preparation of solid lipid nanoparticle can be stabilized by adding a biocompatible surfactant in the proper ratio [70]. They are generally made up of the hydrophobic core to which a monolayer of phospholipid is coated [71].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Novel Nanocarriers for Ethnopharmacological Formulations

Sivapriya¹,

Ponnarmadha²,

Nazeer³

et al. 2018

Int J App Pharm

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A numerous novel drug delivery system has been emerged by combining herbal medicine with nanotechnology to administer drugs encompassing the enhancement of compatibility and efficacy. The herbal phytoconstituents are compatible compared to the chemical active pharmaceutical ingredients (APIs). But the therapeutic consequence of the phytoconstituent is limited due to poor aqueous solubility. Therefore, the demand to develop a system which improves the solubility of the phytomedicine is mounting rapidly. Nanotechnology plays a vital role in increasing the solubility, enhancing the bioavailability and improving the drug specificity of bioactive constituents. Nanosystems such as liposomes, nanoparticles, phytosomes, ethosomes, nanoemulsions and solid lipid nanoparticles are used to deliver the bioactive constituent at an adequate dose to the site of action and during the entire treatment period. The current review discusses the various novel drug delivery systems which have been developed to attain better therapeutic response of the herbal drug.

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“…SLN prepared by ultra-sonication showed a limited digestion of the lipid excipient when tested in-vitro lipolysis using a pH-stat apparatus, although SLN produced by SFE were not digested by lipases. So, it was concluded that the presence of surfactant allows the adsorption of the lipase and degradation of glyceryl behenate 14 .…”

Section: Digestibility Of Lipidsmentioning

confidence: 99%

“…The stability and zeta potential of SLN prepared with glyceryl behenate is affected by storage conditions 16 . Jannin et al reported that SLN prepared with glyceryl dibehenate were not digested by pancreatin during in-vitro lipolysis test 14 . In one of the study, it was found that SLN prepared with glyceryl behenate showed higher drug entrapment than compare to glyceryl stearate, as it contains mono, di and triglycerides and produces less ordered lipid crystals than glyceryl stearate 17 .…”

Section: Introductionmentioning

confidence: 99%

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

Bhatt¹,

Sharma²,

Singh³

et al. 2018

actapharm

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Oral administration of drugs having low water solubility is hampered by various enzymatic barriers present in gastrointestinal (GI) tract. Lipid nanoparticles based on solid matrix have emerged as a potential drug delivery system to improve the absorption and bioavailability of several drugs, especially lipophilic compounds. Solid lipid nanoparticles (SLN) are reported as the most promising technology for oral administration and offered several advantages over conventional dosages formulations including, enhancement in solubility, stability, permeability, and bioavailability with minimal side effects. In this review, we have highlighted recent advances in the development of SLN for the oral, parenteral, rectal, and topical administration of various drugs. We have also summarized the applications of SLN in the treatment of various diseases like tuberculosis, cancer, diabetes, and several nervous system related disorders. sustained release, timed release, extended release, and targeted release of a drug. The predominance of nanoparticles over the other drug delivery systems enables them to use for drug targeting. Nanoparticles are 10-100nm in size in which drug is either dispersed or entrapped in a matrix, encapsulated as the solid solution or may be adsorbed on the surface 2 .The nanoparticles are designed to provide intimate contact with GI epithelium, prolong residence time and allow permeation across the cell membrane. A pre-systemic metabolism of a drug can be avoided by using nanoparticles 3 . Lipid nanoparticles are safe to use as they contain lipids, which are included in the category of generally recognized as safe (GRAS). Solid Lipid NanoparticlesSolid lipid nanoparticles are an advanced and rapidly budding field of nanotechnology with several applications in pharmaceutical science. SLN were developed first in 1991. These are the colloidal carriers possesses an average diameter of 10 to 1000nm. They composed of single lipid core matrix dispersed in an aqueous surfactant solution. The carriers like liposomes, polymeric micelles, and porous solids can also be used to enhance the aqueous solubility of a drug. But SLN not only helps to increase the solubility of a drug but also offers target release of drugs. SLN can be used as a carrier for lipophilic as well as hydrophilic drugs 4 . SLN provides stability to the solid lipid matrix and overcomes the disadvantages of liposomes, which includes stability problems 5 . Instead of polymeric nanoparticles, SLN are found to be more compatible with the biological system. Exclusive properties of SLN such as smaller size, larger surface area and interaction of phases at the interface make them valuable candidate 2 . The release of encapsulated compounds is controlled by solid lipid matrix, which also improves the stability of incorporated lipophilic ingredients. The type of lipids, surfactants and their concentration in the formulation of SLN adjust the particle size, drug loading, and release behavior of drugs 5 . The physicochemical characteristics of the solid lipid...

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Evaluation of the digestibility of solid lipid nanoparticles of glyceryl dibehenate produced by two techniques: Ultrasonication and spray-flash evaporation

Cited by 20 publications

References 15 publications

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

Novel Nanocarriers for Ethnopharmacological Formulations

Solid lipid nanoparticles: a promising technology for delivery of poorly water-soluble drugs

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