Evaluation of the diagnostic utility of cytologic examination of renal fine-needle aspirates from dogs and the use of ultrasonographic features to inform cytologic diagnosis

McAloney, Camille A.; Sharkey, Leslie C.; Feeney, Daniel A.; Seelig, Davis; Avery, Anne C.; Jessen, Carl R.

doi:10.2460/javma.252.10.1247

Cited by 13 publications

(11 citation statements)

References 28 publications

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“…Furthermore, renal FNA can be used to assist with the cytological diagnosis of solitary or multifocal masses, dramatic echotextural changes, and renomegaly without hydronephrosis on abdominal ultrasonography [4]. The sensitivity and specificity of cytology for the detection of neoplastic lesions is 78% and 50%, respectively [28]. Compared to histopathological examination, it is an accurate and reliable method for lymphoma diagnosis [7], with a 100% sensitivity rate [28].…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity of cytology for the detection of neoplastic lesions is 78% and 50%, respectively [28]. Compared to histopathological examination, it is an accurate and reliable method for lymphoma diagnosis [7], with a 100% sensitivity rate [28]. Conversely, the diagnosis of RCC through cytologic examination alone can be challenging because RCC histopathologic features have variable cellular pleomorphism [28].…”

Section: Discussionmentioning

confidence: 99%

“…Compared to histopathological examination, it is an accurate and reliable method for lymphoma diagnosis [7], with a 100% sensitivity rate [28]. Conversely, the diagnosis of RCC through cytologic examination alone can be challenging because RCC histopathologic features have variable cellular pleomorphism [28]. In humans, RCCs appear predominantly solid but often have areas of hemorrhage or necrosis [29].…”

Section: Discussionmentioning

confidence: 99%

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Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma

et al. 2019

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In veterinary medicine, abdominal ultrasonography is used to rank the differential diagnosis of renal lesions. However, a conventional sonographic examination may show nonspecific findings. The purpose of this study was to assess the computed tomography (CT) findings of canine renal tumors, including renal cell carcinoma (RCC), lymphoma, and hemangiosarcoma (HSA). In this retrospective study, the following CT parameters were recorded for each dog: 1) extent of renal involvement of tumors, 2) enhancement pattern, 3) number of renal tumors, 4) renal tumor vessel enhancement in the corticomedullary phase, 5) presence of lymphadenopathy and lung metastasis, and 6) attenuation values of the renal tumors on the pre- and post-contrast corticomedullary, nephrographic, and excretory phase images. Fifteen dogs met the inclusion criteria, of which nine had RCCs, four had lymphomas, and two had HSAs. RCCs tended to show heterogeneous enhancement and unilateral renal involvement, and vessel enhancement was detected in the corticomedullary phase in dogs with RCC. Conversely, renal lymphomas showed homogeneous enhancement, bilateral renal involvement, and multiple masses; in these dogs, no vessel enhancement was detected in the corticomedullary phase, and the incidence of lymphadenopathy was low. However, in dogs with lymphadenopathy, the renal lymphoma was associated with regionally severe lymphadenopathy. Finally, renal HSAs tended to show heterogeneous enhancement with a non-enhanced area and unilateral renal involvement; in these dogs, vessel enhancement was detected in the nephrographic phase, with the enhancement expanding around the vessel. These findings had no significant differences. Further studies with a larger sample size are required to examine the association between CT and histopathological findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma

et al. 2019

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“…Вважають, що значне збільшення розмірів лімфатичних вузлів, їх округлості, Solbiati-індексу (SI), співвідношення між короткою віссю і довжиною лімфатичного вузла (S/L) та гіпоехогенні зміни в лімфатичних вузлах у собак із злоякісною лімфомою стають показовими параметрами злоякісності. Дослідники подають ультрасонографічні характеристики ниркової лімфоми собак, критерії диференціювання пухлинних і непухлинних уражень (Taylor et al, 2014;McAloney et al, 2018;Tanaka et al, 2019). Останнім часом у медичній і ветеринарній онкології дискутується можливість заміни біопсії сучасними методами діагностичної візуалізації: ультразвукове дослідження з контрастним підсиленням; комп'ютерна томографія; позитронно-емісійна томографія; магнітнорезонансна томографія (Škor, 2019).…”

Section: діагностикаunclassified

Diagnostic features of canine lymphoma (a review)

Shevchik¹,

Samoyluk²

2020

TAVM

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Canine lymphoma is a large and complex field of oncohematology. The updated classification system of the World Health Organization (WHO), which is based on clinical, topographic, cytomorphological, immunophenotypic, genetic, and molecular characteristics of neoplastic cells, is recognized as the basic systematization of canine lymphoma. The variety of forms, subtypes of canine lymphoma, the systemic nature of the disease and the increase in cases of their detection, determine the importance and relevance in veterinary oncology of a comprehensive study of this disease. The main vector in the disease control and proper patient management is the timely and accurate diagnosis. The diagnostic scheme for lymphoma includes a medical history and physical examination, hematology, biochemical blood analysis, and urine tests, diagnostic imaging of the chest and abdominal cavities, pathomorphological studies, and cell immunophenotyping. However, the basis for the final diagnosis is cytological and histological methods with cell immunophenotyping. The differentiation clusters of Band T-cells of canine lymphomas are slightly different from those used for human lymphoma immunophenotyping. High-grade canine lymphomas from mature lymphocytes are detected in 86% of cases, with multicentric large B-cell lymphoma being recognized as the most common in the world. The use of modern, high-tech diagnostic methods (ultrasonography, tomography, cytology, molecular genetic) by foreign veterinary oncologists not only promotes a quick and accurate diagnosis but allows scientists to make important discoveries. Consideration of paraneoplastic syndromes may promote earlier detection of dogs' lymphomas. Significance of prognostic factors and understanding of the pathogenesis of lymphoma were evaluated for the veterinarian to make the right clinical decisions, make a long-term prognosis and select appropriate therapy. The difficulty of making an accurate diagnosis of lymphoma is associated with many diagnostic procedures and various factors affecting them, which ultimately requires the formation of a clear diagnostic algorithm.

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“…Ultrasound (US) evaluation of the kidney is a routine test commonly used in veterinary medicine [ 1 ]. B-mode (brightness mode) US evaluation of canine kidneys has been used to the examination of the renal margin, renal cortical echogenicity (RCE) [ 2 3 ], and calculi [ 4 ] and lesions such as cysts and neoplastic masses [ 5 6 ].…”

Section: Introductionmentioning

confidence: 99%

Can distinction between the renal cortex and outer medulla on ultrasonography predict estimated glomerular filtration rate in canine chronic kidney diseases?

et al. 2020

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Background: Quantitative evaluation of renal cortical echogenicity (RCE) has been tried and developed in human and veterinary medicine. Objectives: The objective of this study was to propose a method for evaluating RCE quantitatively and intuitively, and to determine associations between ultrasonographic renal structural distinction and estimated glomerular filtration rate (eGFR) in canine chronic kidney disease (CKD). Methods: Data were collected on 63 dogs, including 27 with normal kidney function and 36 CKD patients. Symmetric dimethylarginine and creatinine concentrations were measured for calculating eGFR. RCE was evaluated as 3 grades on ultrasonography images according to the distinction between the renal cortex and outer medulla. The RCE grade of each kidney was measured. Results: There was a significant difference in eGFR between the group normal and CKD (p < 0.001). As mean of RCE grades (the mean values of each right and left kidney's RCE grade) increases, the proportion of group CKD among the patients in each grade increases (p < 0.001). Also, severity of RCE (classified as "high" if any right or left kidney evaluated as RCE grade 3, "low" otherwise) and eGFR is good indicator for predicting group CKD (p < 0.001). Conclusions: The degree of distinction between the renal cortex and the outer medulla is closely related to renal function including eGFR and the RCE grade defined in this study can be used as a method of objectively evaluating RCE.

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Evaluation of the diagnostic utility of cytologic examination of renal fine-needle aspirates from dogs and the use of ultrasonographic features to inform cytologic diagnosis

Cited by 13 publications

References 28 publications

Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma

Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma

Diagnostic features of canine lymphoma (a review)

Can distinction between the renal cortex and outer medulla on ultrasonography predict estimated glomerular filtration rate in canine chronic kidney diseases?

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