Evaluation of the diagnostic performance and operational characteristics of four rapid immunochromatographic syphilis tests in Burkina Faso

Bocoum, Fadima Yaya; Ouédraogo, Henri Gautier; Tarnagda, Grissoum; Kiba, Alice; Tiendrébéogo, Simon; Bationo, Fabrice; Liestman, Benjamin; Diagbouga, Serge; Zarowsky, Christina; Traoré, Renan Ernest; Kouanda, Séni

doi:10.4314/ahs.v15i2.8

Cited by 14 publications

(20 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have different specificity and sensitivity values with the SD Bioline Syphilis 3.0 test. Sensitivity values very close to those found in the present study were reported by Herring et al 23 who found 95.0%; Benzaken et al 26 90.2%; Dlamini et al 27 90.1%; Causer et al 21 87.8%; Bocoum et al 28 90%; and Mehra et al 29 92.9%. As for specificity values, the same authors found 94.9%, 99.4%, 98.0%, 98.5%, 98.0% and 98.3%, respectively.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

et al. 2017

View full text Add to dashboard Cite

Objectives In 2012, the WHO estimated that 6 million new cases of syphilis per year would occur worldwide, including 937 000 in Brazil. Early diagnosis and treatment of syphilis are essential to reduce morbidity and prevent transmission. The availability of rapid tests (RTs) for this diagnosis means that testing can be performed more quickly, as a point-of-care test, even in non-laboratory environments and requires only simple technical training to antibodies detection. The objective of this study was to evaluate the performance and operational aspects of seven commercially available RTs for syphilis in Brazil. Methods Seven rapid treponemal tests were evaluated for sensitivity, specificity, accuracy and Kappa value, according to a panel composed of 493 members. The operational performance of the assay was also determined for these tests. results The seven RTs showed sensitivity ranging from 94.5% to 100% when compared with the reference tests and specificity of between 91.5% and 100%. All the RTs evaluated presented good operational performance, and only one failed to present the minimum specificity as defined by Brazil's Ministry of Health. conclusion All the tests presented good operational performance, and the professionals who performed them considered them to be easy to use and interpret. This evaluation is important for making informed choices of tests to be used in the Brazilian Unified Health System. IntrOductIOnSyphilis constitutes a major public health problem. In 2012, the WHO estimated that six million new cases of syphilis per year would occur worldwide.

show abstract

Section: Discussionsupporting

confidence: 90%

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

et al. 2017

View full text Add to dashboard Cite

show abstract

“…These rapid tests for syphilis screening are available in Burkina Faso, and four of them have had their performance and operational characteristics assessed [12]. Unfortunately they are not widely adopted for ANC services.…”

Section: Introductionmentioning

confidence: 99%

Introducing onsite antenatal syphilis screening in Burkina Faso: implementation and evaluation of a feasibility intervention tailored to a local context

Bocoum¹,

Tarnagda

Bationo

et al. 2017

BMC Health Serv Res

View full text Add to dashboard Cite

BackgroundAlthough the advantages of introducing point of care testing for syphilis in antenatal care (ANC) are well documented, there is little evidence on how to address structural issues within health systems. A better understanding of how these interventions work in a range of settings and contexts is needed in order to overcome bottlenecks at health system level. To better understand the relationships between implementation and context we developed and implemented an intervention focused on integrating a rapid screening test for syphilis in ANC services in rural primary health care facilities in Burkina Faso. This manuscript describes the intervention and reports on feasibility and acceptability of the intervention, the facilitators and barriers to the implementation of this intervention and the likelihood that point of care test for syphilis will become routinely incorporated in practice.MethodsIn Kaya Health and Demographic Surveillance System (Kaya HDSS), all 7 primary healthcare facilities were selected for intervention in 2013. A participatory approach was used to design and implement an antenatal syphilis screening intervention. The Normalization Process Model (NPM) proposed by May et al. was adapted in order to identify barriers and facilitators and to explore the likelihood to become routinely incorporated in practice. Registers, Observations (n = 14 ANC 1) of interactions between patients and health workers during ANC and interviews with health workers (n = 14) were our data sources.ResultsAn intervention that included onsite training, provision of supplies and medicines, quality control and supervision was implemented in 7 health facilities in 2013. Rapid syphilis test and treatment were delivered during ANC within the examination room with no specific additional mechanism regarding staff organization. The perceived barriers were lack of training of all staff, workload, stock-outs of consumables and lack of motivation of staff. Key facilitators included political environment, ease of use of test and acceptability to pregnant women.ConclusionsOnsite testing for antenatal syphilis is a feasible and acceptable intervention in ANC at primary health facility in Burkina Faso. The point-of care test for syphilis is more likely to be acceptable by health workers as routine service and incorporated as a normal practice.Trial registrationThe study was retrospectively registered on ClinicalTrials.gov under the Trial Registration Number NCT03156751.

show abstract

“…Positive samples were consecutively tested with a Rapid Plasma Reagin (RPR-CHARBON®) test kit ( BIOLABO SAS, French ), a nontreponemic test [ 30 ]. Alere Determine™ Syphilis TP is a qualitative in vitro immune-chromatographic test detecting antibodies against the Treponema pallidum bacteria in patient's serum, plasma, and whole blood [ 31 ]. Positivity to the Alere Determine™ Syphilis TP test reveals the presence of antibodies against the Treponema pallidum bacteria indicating the presence of either previous, acute, or treated syphilis.…”

Section: Methodsmentioning

confidence: 99%

Syphilis among Female Sex Workers: Results of Point-of-Care Screening during a Cross-Sectional Behavioral Survey in Burkina Faso, West Africa

Ouédraogo

Meda

Zongo

et al. 2018

International Journal of Microbiology

View full text Add to dashboard Cite

Background Syphilis among female sex workers (FSW) remains a public health concern due to its potential impact on their health and the possibility of transmission to their clients, partners, and children. Recent data on the prevalence of syphilis in the population in West Africa are scarce. The objective of this study was to measure the seroprevalence of syphilis serological markers among female sex workers in Burkina Faso. Methods We conducted a cross-sectional survey among FSW between February 2013 and May 2014. Participants were recruited using respondent-driven sampling (RDS) methods in five cities of Burkina Faso (Ouagadougou, Bobo-Dioulasso, Koudougou, Ouahigouya, and Tenkodogo). FSW were enrolled and screened for syphilis using a syphilis serological rapid diagnostic test. Data from all cities were analyzed with Stata version 14.0. Results A total of 1045 FSW were screened for syphilis. Participants' mean age was 27.2 ± 0.2 years. The syphilis serological markers were detected in 5.6% (95% CI: 4.4–7.2) of the participants whereas active syphilis was seen in 1.4% (95% CI: 0.9–2.4). RDS weighted prevalence of syphilis serological markers and active syphilis by city were, respectively, estimated to be 0.0% to 11.0% (95% CI: 8.1–14.7) and 0.0% to 2.2% (95% CI: 1.1–4.4). No syphilis markers were found among Ouahigouya FSW. Low education level and high number of clients were factors associated with syphilis markers among the FSW. Conclusion The prevalence of syphilis markers was high during this study among FSW. This highlights the need to reinforce the comprehensive preventive measures and treatment of syphilis in this population.

show abstract

Evaluation of the diagnostic performance and operational characteristics of four rapid immunochromatographic syphilis tests in Burkina Faso

Cited by 14 publications

References 13 publications

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels

Introducing onsite antenatal syphilis screening in Burkina Faso: implementation and evaluation of a feasibility intervention tailored to a local context

Syphilis among Female Sex Workers: Results of Point-of-Care Screening during a Cross-Sectional Behavioral Survey in Burkina Faso, West Africa

Contact Info

Product

Resources

About