Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium

Effects of Aluminum Exposure on Serum Sex Hormones and Androgen Receptor Expression in Male Rats

“…Aluminum (Al) is ubiquitously distributed in the environment, and abundant evidences showed that the ion (Al 3+ ) can be accumulated in the body tissues through the skin, lungs, and gastrointestinal tract and damage the target organs [1,2]. Humans are frequently exposed to Al from various food additives, therapeutic treatments, and the environment [3].…”

Morphometric and Biochemical Evaluation of Aluminum Intoxicated Rats

“…Reports have shown an association between aluminum accumulation in the brain and antisocial behaviour in learning and development. and disruption of second messenger systems (Agrawal et al, (1996).…”

The influence of citrate, maltolate and fluoride on the gastrointestinal absorption of aluminum at a drinking water-relevant concentration: A 26Al and 14C study

“…Maltol (3-hydroxy-2-methyl-4H-pyran-4-one), a natural product and an approved food additive in the US and Australia, is used as a flavor enhancer in beverages like coffee and chocolate milk and as a favoring agent in breads and cakes. At neutral pH and mM Al concentrations, Al(maltolate) 3 is soluble and stable to hydrolysis [10]. Al maltolate was more toxic to animals and neuronal and glial cells than Al lactate or Al chloride [10,11].…”

“…In patients receiving renal dialysis, Al can cause dialysis encephalopathy, renal osteodystrophy and a hypochromic microcytic anemia [2]. Experiments with rats and mice demonstrated embryo/fetal toxicity after oral administration of a variety of Al salts [3,4].…”