Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System

Erlandsen, E. J; Randers, Else; Kristensen, Jørgen Kvist

doi:10.1080/00365519950185940

Cited by 232 publications

(174 citation statements)

References 4 publications

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“…These suggested that CysC was stable for 7 days at ambient temperature, for 1-2 months at -208C and for at least 6 months at -808C (18,23,24). In our personal experience, the length of stability at -808C can be extended to several years.…”

Section: Stability Of Cyscmentioning

confidence: 81%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

163

145

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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Section: Stability Of Cyscmentioning

confidence: 81%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

163

145

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“…27 No major interference with haemoglobin, bilirubin, triglycerides, and rheumatoid factors have been demonstrated using the assays. 17,25 Reference intervals are established and the same reference interval can probably be used in children older than 1 year and in adults independent of gender. 16,28 Furthermore, cystatin C is independent of muscle mass in contrast to creatinine.…”

Section: Discussionmentioning

confidence: 99%

“…17 The method was a fully automated particle-enhanced nephelometric immunoassay (PENIA). The assay time was 6 min for cystatin C compared to 5 min for creatinine and the sample volume was 40 mL serum or plasma.…”

Section: Methodsmentioning

confidence: 99%

Serum cystatin C as a marker of the renal function in patients with spinal cord injury

et al. 2002

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Objective: To investigate the relationship between serum cystatin C, serum creatinine, and 51 Cr-EDTA-clearance in patients with spinal cord injury. Setting: The Spinal Cord Unit, Viborg-Kjellerup County Hospital. Methods: Twenty-four men and seven women aged 20.3 to 68.0 years with motor complete spinal cord injury (ASIA A or B) were included. Serum cystatin C was measured by an automated particle-enhanced nephelometric immunoassay (Dade Behring), serum creatinine by an enzymatic method (Vitros 950), and 51 Cr-EDTA-clearance by a multiple plasma sample method. Results: A linear relationship was found between 51 Cr-EDTA-clearance and the reciprocal values of cystatin C and creatinine. The correlation coe cient between 51 Cr-EDTA-clearance and 1/cystatin C was 0.72 compared to the correlation coe cient between 51 Cr-EDTAclearance and 1/creatinine being 0.26. Comparison of the area under the curves in the nonparametric receiver operating characteristics (ROC) plots for serum cystatin C (area under the curve (AUC)=0.912; SE=0.065), and serum creatinine (AUC=0.507; SE=0.115) revealed signi®cant di erences (P-values=0.0005). Conclusion: In patients with spinal cord injury serum cystatin C is a better marker of the renal function compared to serum creatinine.

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“…Previous research suggests that cystatin C measures have little variation because of storage time or freeze-thaw cycles (1,16,17). A review of potential applications of cystatin C in research and clinical decision-making has been published (18); standardization of cystatin C measurements-a common issue with any analyte that gains widespread usage-should be a priority.…”

Section: Resultsmentioning

confidence: 99%