Evaluation of the cytotoxic potential of a new pentacyclic triterpene from
            <i>Rhododendron arboreum</i>
            stem bark

Ali, Sajid; Nisar, Muhammad; Qaisar, Muhammad; Khan, Adam Z.; Khan, Abid Ali

doi:10.1080/13880209.2017.1343359

Cited by 16 publications

(14 citation statements)

References 18 publications

(16 reference statements)

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“…Therefore, even if observing some time-dependent fractionation, the relative composition in terpenes of the different fractions is quite similar and, consequently, not significant differences in bioactivities could be expected. In this sense, as mentioned above, distinct biological activities have been associated to the presence of different families of terpenes [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56], and therefore, a better separation of these terpenes is mandatory. Moreover, a different selectivity would make the identification of the different terpenes easier.…”

Section: Time-dependent Scco2 Fractionation Of Terpenes From Olive Leavesmentioning

confidence: 99%

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Montenegro

Álvarez‐Rivera

Mendiola

2021

Foods

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This work reports the use of GC-QTOF-MS to obtain a deep characterization of terpenoid compounds recovered from olive leaves, which is one of the largest by-products generated by the olive oil industry. This work includes an innovative supercritical CO2 fractionation process based on the online coupling of supercritical fluid extraction (SFE) and dynamic adsorption/desorption for the selective enrichment of terpenoids in the different olive leaves extracts. The selectivity of different commercial adsorbents such as silica gel, zeolite, and aluminum oxide was evaluated toward the different terpene families present in olive leaves. Operating at 30 MPa and 60 °C, an adsorbent-assisted fractionation was carried out every 20 min for a total time of 120 min. For the first time, GC-QTOF-MS allowed the identification of 40 terpenoids in olive leaves. The GC-QTOF-MS results indicate that silica gel is a suitable adsorbent to partially retain polyunsaturated C10 and C15 terpenes. In addition, aluminum oxide increases C20 recoveries, whereas crystalline zeolites favor C30 terpenes recoveries. The different healthy properties that have been described for terpenoids makes the current SFE-GC-QTOF-MS process especially interesting and suitable for their revalorization.

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Section: Time-dependent Scco2 Fractionation Of Terpenes From Olive Leavesmentioning

confidence: 99%

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Montenegro

Álvarez‐Rivera

Mendiola

2021

Foods

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“…The IC50 values obtained from the growth curves are presented in Table 2. Rhododendron arboreum exhibits cytotoxic effect on human renal, liver, lung, and ovarian cancer cells (Ali et al, 2017). Recently, Bilir et al (2018b) reported that the aqueous extract of Rhododendron ponticum flowers exhibits cytotoxic effect on the glioma cells.…”

Section: Resultsmentioning

confidence: 99%

Rhododendron luteum Yaprak Ekstraktının İnsan Kanser Hücre Serilerindeki Sitotoksik Etkisi

Demir

Turan

Aliyazıcıoğlu

2018

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Rhododendron luteum belongs to the genus Rhododendron, members of which are frequently used in folk medicine. Various studies have investigated the cytotoxic effect of different Rhododendron species, but there have been limited studies of the cytotoxic effect of R. luteum. The aim of this study was to investigate the antioxidant properties and cytotoxic effect of R. luteum leaf extract on the human cancer cells. The total phenolic content (TPC), total flavonoid content (TFC), and reducing power of the extract were evaluated using spectrophotometric procedures. The cytotoxic effect of the extract on five cancers (human breast, colon, lung, prostate, and liver carcinoma) and human fibroblast cells was determined using the MTT assay. TPC and reducing power values of extract were found 173.2±3.97 mg gallic acid equivalents, and 629.5±3.49 mg trolox equivalents per g sample, respectively. R. luteum leaf extract exhibited selective cytotoxicity especially against colon (1.9 fold) and liver (2.2 fold) cancer cells compared to normal fibroblast cells. This is the first study to reveal the cytotoxic effect of R. luteum leaf extract. Further studies are now needed to identify the cytotoxic molecules in the extract and their mechanisms.

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“…An ursolic acid derivative, 15-oxoursolic acid, was isolated from the ethyl acetate fraction of the stem bark of Rhododendron arboreum Sm. extract and physicochemically characterized; its strongest in vitro antiproliferative effect was recorded against the human ovarian carcinoma (MDR-2780AD) cell line with low micromolar IC 50 values ( 153 ).…”

Section: Triterpenes As Therapeutic Agents In Sex Hormone-dependent Cmentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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Evaluation of the cytotoxic potential of a new pentacyclic triterpene from Rhododendron arboreum stem bark

Abstract: This study highlighted the potential of 15-oxoursolic acid to be further explored as a new lead compound for cancer chemotherapy.

Cited by 16 publications

References 18 publications

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process

Rhododendron luteum Yaprak Ekstraktının İnsan Kanser Hücre Serilerindeki Sitotoksik Etkisi

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

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