Evaluation of the Current Disease Scoring Systems in Familial Mediterranean Fever

Demirkaya, Erkan; Livneh, Avi

doi:10.1007/978-3-319-14615-7_7

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The activity periods of the patient groups were made according to the positive clinical and laboratory findings made by the specialist rheumatologist. In the FMF patient group, clinical findings were retrospectively obtained from the patient files in the hospital archive to calculate the Auto‐Inflammatory Disease Activity Index (AIDAI) score, 19 which is a measure of the disease activity of the patients. AIDAI scores were calculated by reaching the parents of the patients who did not have a file and/or whose clinical examination information was missing, via the phone registered in the patient information system, completing their information.…”

Section: Methodsmentioning

confidence: 99%

The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

et al. 2022

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Objective: Our aim was to investigate the possible relationship between the serum S100A12 and Toll-like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) in accordance with the routine biochemical parameters. Furthermore, the effectiveness of these 2 biomarkers in distinguishing FMF from JIA has been evaluated.Method: Sixty-nine children with FMF, 68 children with JIA, and 35 healthy children were included in this study. S100A12 and TLR4 levels were measured by the sandwich enzyme-linked immunosorbent assay technique. Results:In the FMF patient group, serum S100A12 level was found to be significantly higher than in both the JIA and control groups (P = .000 and P = .000, respectively).Although S100A12 levels were higher in the attack period compared to the attackfree period, this increase was not statistically significant (P > .05). TLR4 levels were statistically significantly higher in the attack period compared to the attack-free period in children with FMF (P < .05). Although there was no relationship between S100A12 levels and disease activity, there is a clear correlation between S100A12 and the Auto-Inflammatory Disease Activity Index in attack-free FMF patients (r = 0.612 P = .000). Conclusion:Serum S100A12 levels were not found to be a potentially valuable biomarker for assessing disease activity in either FMF or JIA. However, TLR4 levels were found to be a valuable biomarker for assessing disease activity in children with FMF.Further research which includes serial monitoring of S100A12 and TLR4 levels in a large cohort will provide detailed information about accuracy of these 2 potential biomarkers in both patients group.

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Section: Methodsmentioning

confidence: 99%

The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

et al. 2022

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“…A standardised assessment of disease severity will help physicians to compare patients with regard to amenability to treatment, cost effectiveness and safety of treatment, QOL, chronic sequel, burden imposed on the medical authorities and prediction of expected clinical course. Severity scoring systems have been developed to objectively quantify the disease severity for both therapeutic and prognostic purposes 3. A standardised assessment of disease severity will help physicians both to evaluate the response to therapy and to conduct clinical trials, especially in patients with colchicine-resistant FMF.…”

Section: Introductionmentioning

confidence: 99%

Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF)

et al. 2016

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Current Research in Outcome Measures for Pediatric Rheumatic and Autoinflammatory Diseases

et al. 2016

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A rational management of children and adolescents with rheumatic and autoinflammatory diseases requires the regular assessment of the level of disease activity and of child health and well-being through the use of well-validated outcome measures. Ideally, such instruments should be simple and feasible and easily applicable in standard clinical practice. In recent years, a number of novel outcome measures have been developed and validated for use in pediatric patients with rheumatic and autoinflammatory illnesses. Furthermore, there has been an increased focus on the appraisal of child and parent perception of the disease impact. The new tools have markedly enlarged the spectrum of disorders and health domains that can be assessed in a standardized way. This progress will help to enhance the reliability of research studies and clinical trials. The aim of the present review is to provide an update of the recent advances in this field of research.

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Evaluation of the Current Disease Scoring Systems in Familial Mediterranean Fever

Cited by 3 publications

References 23 publications

The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF)

Current Research in Outcome Measures for Pediatric Rheumatic and Autoinflammatory Diseases

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