Background/Aim. Psoriasis is a chronic multisystem, inflammatory and
immune-mediated dermatological disease of a relapsing nature. It does not
only affect objective parameters such as skin and joint, with different
intensity involvement with changes and the degree of changes but also
significantly affects the health-related quality of life. The aim of the
study was to determine the clinical severity and quality of life of patients
with moderate to severe psoriasis and to examine the association between
those parameters before and after the treatment. Methods. This
cross-sectional study included 183 patients diagnosed with moderate to
severe psoriasis. The severity of the clinical picture was determined by
calculating Psoriasis Area and Severity Index (PASI) by a dermatologist,
while the quality of life was assessed using Dermatology Life Quality Index
(DLQI) questionnaire and the Psoriasis Life Stress Inventory (PLSI). Disease
severity and quality of life were measured at the baseline visit and after
16th week of therapy. Results. The average PASI score at the beginning of
therapy was 23.1?6.5, while after the 16 weeks, this value was 4.36?4.86.
The DLQI score was 20.8?5.0 at the start of therapy and 6.20?6.16 after 16
weeks. The PLSI score was 35.37?8.84 initially and 12.75?12.82 after the 16
weeks of therapy. On the assessment of the correlation between the PASI and
PLSI, the PASI score was found to be in a high positive correlation with the
PLSI (r=0.702, ?<0.001) in the 16th week of therapy, but the correlation is
moderate between the DLQI and PASI (r=0.683, ?<0.001). We failed to find any
significant differences between PASI and DLQI scores (r=0.080, ?=0.284) and
between PASI and PLSI scores (r=0.109, ?=0.140) in the baseline. Conclusion.
Patients with severe psoriasis experience a significant reduction in their
quality of life, accompanied by a high level of psychosocial stress.
Observed improvements in quality of life have shown a moderate correlation,
while lower levels of psychosocial stress have strongly correlated with the
severity of the clinical presentation. This may indicate a complex
interaction between psychological factors and physical health in patients
with psoriasis.