Evaluation of the Correlation between Colour Power Doppler Flow Imaging and Vascular Endothelial Growth Factor in Breast Cancer

Wang, Yuchen; Hj, Dan; Fan, Jin‐Hu; Sb, Wen

doi:10.1177/147323001003800335

Cited by 20 publications

(15 citation statements)

References 16 publications

(14 reference statements)

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“…(Power Doppler mode was used to grade the blood flow in LN. The amount of blood flow was classified from 0 to 3, according to Wang et al 12 …”

Section: Methodsmentioning

confidence: 99%

“…The broad application of EBUS in daily clinical practice opens new opportunities for ultrasound‐guided LN sampling. Several studies have shown that sonographical findings seem to be associated with malignancy in LN, for example, in head and neck, breast, cervix, or oesophageal cancer 9–16 . In a retrospective lung cancer study, four sonographical features were found to be predictive of malignancy in mediastinal LN (round shape, distinct margin, heterogeneous echogenicity, presence of coagulation necrosis sign) 17 …”

Section: Introductionmentioning

confidence: 99%

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Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: A new ultrasound scoring system

Schmid-Bindert¹,

Huang²,

Kähler³

et al. 2012

Respirology

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The assessment of ultrasound criteria during routine EBUS examinations is feasible and reproducible with very good interrater agreement. If less than three of the described criteria are present, a LN has a very low chance of being malignant. The best single criterion to predict malignancy is heterogeneity. The introduction of the sum score of ultrasound criteria could potentially increase diagnostic accuracy.

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“…(Power Doppler mode was used to grade the blood flow in LN. The amount of blood flow was classified from 0 to 3, according to Wang et al 12 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: A new ultrasound scoring system

Schmid-Bindert¹,

Huang²,

Kähler³

et al. 2012

Respirology

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“…Other modalities that provide measures of regional perfusion include DCE-MRI (often used to measure the effect of anti-angiogenic agents) [9,10], Doppler ultrasound [72,73], and optical imaging [15]. Agents for specific imaging of angiogenesis (for example, 18 F -galacto arginine-glycine-aspartate (RGD) peptide) have also undergone early testing in humans [74].…”

Section: Molecular Imaging For Breast Cancer Characterizationmentioning

confidence: 99%

Advances in molecular imaging for breast cancer detection and characterization

Specht

Mankoff

2012

Breast Cancer Res

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Advances in our ability to assay molecular processes, including gene expression, protein expression, and molecular and cellular biochemistry, have fueled advances in our understanding of breast cancer biology and have led to the identification of new treatments for patients with breast cancer. The ability to measure biologic processes without perturbing them in vivo allows the opportunity to better characterize tumor biology and to assess how biologic and cytotoxic therapies alter critical pathways of tumor response and resistance. By accurately characterizing tumor properties and biologic processes, molecular imaging plays an increasing role in breast cancer science, clinical care in diagnosis and staging, assessment of therapeutic targets, and evaluation of responses to therapies. This review describes the current role and potential of molecular imaging modalities for detection and characterization of breast cancer and focuses primarily on radionuclide-based methods.

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“…Recently, several studies have demonstrated useful applications of ultrasound in dermatology, particularly as an indicator of cutaneous fibrosis or to evaluate melanoma lesions [16,17]. Our experience suggests that skin ultrasonology, particularly when performed with an extremely high frequency probes, could be important for both the diagnosis and therapy management of KS, in association with color power Doppler flow imaging, to detect the vascular activity of the cutaneous lesions [18,19]. …”

Section: Introductionmentioning

confidence: 99%

AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?

Solivetti

Elia

Latini

et al. 2011

J Exp Clin Cancer Res

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BackgroundKaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS (CKS) or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease.MethodsCutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes; 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. For each patient, a target skin lesion was selected on the basis of size (diameter from 0.4 to 2 cm). Each lesion was analyzed in terms of size, depth and color Doppler pattern.ResultsThe B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients, whereas the color Doppler signal, which is associated with vascular activity, was detected in the KS lesions of 6/8 AIDS-KS patients (75.0%) and in 2/16 CKS (16,7%); the latter two patients showed a clinically progressive and extensive disease stage (IV B).ConclusionsOur preliminary results suggest that small cutaneous KS lesions - in both CKS and AIDS-KS patients- display similar B-mode ultrasound patterns ( hypoechoic, well defined, superficial lesions). However, the color Doppler signal, which is associated with endothelial activity and angiogenesis, which play a substantial role in KS progression, could constitute a useful tool for evaluating disease activity.

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Evaluation of the Correlation between Colour Power Doppler Flow Imaging and Vascular Endothelial Growth Factor in Breast Cancer

Cited by 20 publications

References 16 publications

Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: A new ultrasound scoring system

Predicting malignancy in mediastinal lymph nodes by endobronchial ultrasound: A new ultrasound scoring system

Advances in molecular imaging for breast cancer detection and characterization

AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?

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