Evaluation of the Correlation between Spot Urinary Protein/Creatinine Ratio and Serum Uric Acid and its Association with Feto-maternal Outcome in Hypertensive Pregnancy

Chadha, Arzoo; Salve, Mehul; Bapat, Anita

doi:10.31782/ijcrr.2020.sp77

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…In a research including emergency cases, standardized blood samples following a 12-hour overnight fast was not possible. As a result, the validity of the total serum T G and T R L -T G values found in this investigation is restricted, and statistical analysis for these parameters was ignored [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipid and Lipoprotein Concentrations in Pregnancy Induced Hypertension

Bukhari¹,

Firdus²,

Jalal³

et al. 2022

PJMHS

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Background and aim: Variation in serum lipid profile is associated with hypertension. Abnormal lipid profile directly affects the endothelial dysfunction and significantly associated with atherosclerotic cardiovascular diseases. Hypertension is the pregnancy toxaemia associated key feature which is considered to be caused by vasospastic phenomena in placenta, kidney, brain, and uterus. The current study aimed to assess plasma lipid and lipoprotein concentrations in pregnant women with hypertension (PIH). Methods: This study was conducted on 66 (36 PIH cases, 30 control cases) age matched women in the Department of Obstetrics and Gynecology, Moulvi Ameer Shah Memorial Hospital, Peshawar from October 2021 to June 2022. The criteria for preeclampsia were proteinuria, and proteinuria after pregnancy, hypertension, edema, and reversal of hypertension. Subjects' fasting venous blood samples were collected. Plasma was isolated from heparine anticoagulated blood. In a preservative bottle (500 mg/1000 mL urine) of Na2B4O7, urine was collected after 24 hours. Urine and plasma were kept at -80°C until the assay. Total cholesterol levels, HDL-C, and triglyceride were enzymatically measured. The amount of spectrophotometric and malondialdehyde was measured for plasma lipid peroxidation. SPSS version 26 was used for data analysis. Results: There was a significant increase in proteinuria, mean diastolic, and systolic pressure of preeclampsia patients than the control group. Total triglyceride, malondialdehyde (MDA), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo-B) in a study group were significantly higher as compared to control. Whereas the study group had lower high density lipoprotein cholesterol (HDL-C) than that of control group. The total cholesterol concentration, plasma protein, gestational age, apo-A, and hemoglobin had no statistical significance in both groups. Conclusion: The present study suggested that abnormal lipid metabolism, high triglycerides, specifically LDL-C and lipid peroxides, and low HDL-C concentrations, may lead to the vascular dysfunction and preeclampsia is associated with oxidative stress. There are only minor differences in lipoprotein concentrations and serum lipid between PIH women and women with uncomplicated pregnancy. Keywords: Plasma lipid, Lipoprotein concentration, Pregnancy-induced hypertension

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Section: Discussionmentioning

confidence: 99%

Plasma Lipid and Lipoprotein Concentrations in Pregnancy Induced Hypertension

Bukhari¹,

Firdus²,

Jalal³

et al. 2022

PJMHS

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“…Thorat et al [19] and Singh et al [20] reported studies on different IVF related issues. Chadha et al [21] and Dhingra et al [22,4,5] reported about fetomaternal outcomes of hypertensive pregnancy. Studies on related aspects of pregnancy and maternal health were reviewed [6,20].…”

Section: Discussionmentioning

confidence: 99%

“…Over the past 20 years, infertility treatments have steadily increased and proven effective in achieving significant successful conception rates and live birth rates, even among women younger than 35 years of age [3]. Assisted reproductive technology processes are used to induce assisted pregnancies, including the non-invasive ovulation stimulation system accomplished through specific pharmacological agents [4][5][6][7][8][9][10]. However, these therapies continue to raise criticism because they have been linked, at least in the early years of their widespread adoption, to adverse obstetric and perinatal outcomes, including pregnancy-related hypertensive complications (preeclampsiaand gestational hypertension) [11].…”

Section: Introductionmentioning

confidence: 99%

Management of Hypertension in Elderly Pregnant Women with IVF Conception: A Case Report

Kawale

Patil

2021

JPRI

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Introduction: Hypertensive complications associated with pregnancy are the primary cause of maternal and fetal morbidity. Early development of cardiovascular disease is also anticipated relatively early after pregnancy is terminated. Over the past 20 years, infertility treatments have steadily increased and proven effective in achieving significant successful conception rates and live birth rates, even among women younger than 35 years of age. Symptoms and important clinical findings: A 45 year sold female was admitted in AVBRH on date 22/01/2021 with chief complaint of breathing difficulty (elderly G5P1D1A3 with 28 weeks of gestational age)having history of previous LSCS with IVF conception with gestational hypertension. Obstetric history: Patient had bad obstetric history of three abortionsand one still-birth. In 2017 she had got the menopause. After menopause she took the treatment in AVBRH Sawangi (M) Wardha and got the regular menses.After regular menses, shereceived IVF cycle and she was conceived in 2nd IVF cycle. The main diagnoses, therapeutic interventions, and outcomes: After physical examination and investigations, this case was diagnosed having 28 weeks of gestation with hypertension. Patient had previous history of LSCS.Patient was treated with antihypertensive drugs to reduce the symptoms of eclampsia. Alsoshe was provided calcium supplement and iron supplement. Present case was stable but ultrasonography revealedsign of stage I- intra uterine growth restriction. Nursing perspectives: Fluid replacement i.e. DNS and RL, monitoring offetal heart rate and vital signs per hourly. Conclusion: Conception with in vitro fertilization have increased risk of gestational hypertension as well as fetal complications like intra uterine growth restriction. But timely treatment and management improves the outcome of pregnancy.

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“…Another study reflected on correlation with antenatal care and antenatal counselling for congenital anomaly tests [7]. A number of studies on hypertension in pregnancy [8,9] and different types of complications in pregnancy [10][11][12] were reported. Few of the related studies on antenatal services [13] and heart problems [14,15] were reviewed [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Case Report on Management of Pregnancy in a Patient with Small Muscular Ventricular Septal Defect

Fating

2021

JPRI

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Introduction: Maternal morbidity and mortality during pregnancy is significantly associated with hypertensive disorders. Patient history: A 33 years old female was admitted in AVBRH with chief complaint of breathing difficulty with G2P1A1L1 having 30 weeks of gestational age with previous LSCS and conception with small muscular ventricular septal defect, normal function and rhythm for the period of gestation. Obstetric history: Patient had bad obstetric history of 1 induced abortion. Clinical findings: The patient had undergone various investigations like blood tests, USG, Physical examination and antenatal per abdominal examination. Medical Management: Patient was treated with calcium supplement and iron supplement. Nursing management: Administered fluid replacement i.e. DNS and RL, Foetal monitoring, hourly vital sign monitoring. Conclusion: Timely treatment of Ventricular Small Muscular Septal Defect and Management in pregnancy improved the outcome of pregnancy.

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Evaluation of the Correlation between Spot Urinary Protein/Creatinine Ratio and Serum Uric Acid and its Association with Feto-maternal Outcome in Hypertensive Pregnancy

Cited by 4 publications

References 10 publications

Plasma Lipid and Lipoprotein Concentrations in Pregnancy Induced Hypertension

Plasma Lipid and Lipoprotein Concentrations in Pregnancy Induced Hypertension

Management of Hypertension in Elderly Pregnant Women with IVF Conception: A Case Report

Case Report on Management of Pregnancy in a Patient with Small Muscular Ventricular Septal Defect

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