Evaluation of the constant-infusion technique to determine inulin clearance in the rat.

DiMeola, H J; Siegel, Norman J.; Kaufman, Jack M.; Hayslett, John P.

doi:10.1152/jappl.1974.36.2.261

Cited by 4 publications

(1 citation statement)

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“…The definition of the inter-compartmental transfer constants in the MTL3 model is provided in Table 1 and the NONMEM code of the MTL3 model is provided in Text S1 in the supplements. For all models, the clearance was fixed to Cl = 0.04 ml⋅s −1 based on reported rat clearance values [6].…”

Section: Methodsmentioning

confidence: 99%

Assessing Antiangiogenic Therapy Response by DCE-MRI: Development of a Physiology Driven Multi-Compartment Model Using Population Pharmacometrics

Steingoetter

Menne²,

Braren

2011

PLoS ONE

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Dynamic contrast enhanced (DCE-) MRI is commonly applied for the monitoring of antiangiogenic therapy in oncology. Established pharmacokinetic (PK) analysis methods of DCE-MRI data do not sufficiently reflect the complex anatomical and physiological constituents of the analyzed tissue. Hence, accepted endpoints such as Ktrans reflect an unknown multitude of local and global physiological effects often rendering an understanding of specific local drug effects impossible. In this work a novel multi-compartment PK model is presented, which for the first time allows the separation of local and systemic physiological effects. DCE-MRI data sets from multiple, simultaneously acquired tissues, i.e. spinal muscle, liver and tumor tissue, of hepatocellular carcinoma (HCC) bearing rats were applied for model development. The full Markov chain Monte Carlo (MCMC) Bayesian analysis method was applied for model parameter estimation and model selection was based on histological and anatomical considerations and numerical criteria. A population PK model (MTL3 model) consisting of 3 measured and 6 latent (unobserved) compartments was selected based on Bayesian chain plots, conditional weighted residuals, objective function values, standard errors of model parameters and the deviance information criterion. Covariate model building, which was based on the histology of tumor tissue, demonstrated that the MTL3 model was able to identify and separate tumor specific, i.e. local, and systemic, i.e. global, effects in the DCE-MRI data. The findings confirm the feasibility to develop physiology driven multi-compartment PK models from DCE-MRI data. The presented MTL3 model allowed the separation of a local, tumor specific therapy effect and thus has the potential for identification and specification of effectors of vascular and tissue physiology in antiangiogenic therapy monitoring.

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Section: Methodsmentioning

confidence: 99%

Assessing Antiangiogenic Therapy Response by DCE-MRI: Development of a Physiology Driven Multi-Compartment Model Using Population Pharmacometrics

Steingoetter

Menne²,

Braren

2011

PLoS ONE

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Clearance Techniques

Levinsky

Lieberthal

1992

Comprehensive Physiology

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The sections in this article are: History Limitations of Clearance Methods Technical Considerations Constant‐Infusion Technique Other Techniques Single‐Injection (Single‐Shot) Technique Clearance Methods for Estimation of Glomerular Filtration Rate Substances Used as Markers Clearance Methods for Estimation of Renal Plasma Flow Substances Used as Markers p‐Aminohippurate Clearance in Renal Disease Extraction of p‐Aminohippurate as' Index of Medullary Blood Flow Clearance Methods for Analysis of Tubular Function Localization of Water and Sodium Reabsorption Estimation of Proximal Reabsorption from Urine Flow Assessment of Sodium Reabsorption in Diluting Segment Assessment of Sodium Reabsorption in Medullary Ascending Limb Determination of Proximal Reabsorption Using Clearance of Lithium

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Possible use of excretion of tubular epithelial cells for the study of the nephrotoxic effect of xenobiotics

Stetinova

Trejtnar

Kopeckỳ

et al. 1996

Journal of Pharmacological and Toxicological Methods

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Evaluation of the constant-infusion technique to determine inulin clearance in the rat.

Cited by 4 publications

References 0 publications

Assessing Antiangiogenic Therapy Response by DCE-MRI: Development of a Physiology Driven Multi-Compartment Model Using Population Pharmacometrics

Assessing Antiangiogenic Therapy Response by DCE-MRI: Development of a Physiology Driven Multi-Compartment Model Using Population Pharmacometrics

Clearance Techniques

Possible use of excretion of tubular epithelial cells for the study of the nephrotoxic effect of xenobiotics

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