Evaluation of the cone beam CT for internal target volume localization in lung stereotactic radiotherapy in comparison with 4D MIP images

Wang, Lu; Chen, Xiaoming; Lin, MingDe; Xue, Junmin; Lin, T; Fan, J; Jin, L; Ma, Charlie M.

doi:10.1118/1.4823785

Cited by 13 publications

(13 citation statements)

References 48 publications

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“…We noticed that the center to center match based on either MIP or AIP could lead to reasonable match accuracy if a patient has a sinusoid-like respiratory motion pattern in which the EIR was nearly 1. This is consistent with Wang’s results in the reference [ 3 ]. However, for the majority of thepatients, exhale duration is longer than the inhale duration [ 8 ].…”

Section: Discussionsupporting

confidence: 94%

“…In the clinic, rather than a normal Helical CT, the maximum intensity projection (MIP) images or average intensity projection (AIP) images derived from a 4D CT dataset have been suggested as reference images to give better alignment with FBCBCT [ 1 – 2 ]. Recent phantom studies have shown that the shape and centroid position of the objects agree with each other between MIP and FBCBCT images when the breathing motion follows a sinusoidal pattern [ 3 ], but the MIP image might overestimate the target volume compared with that determined by an on-board FBCBCT with irregular respiratory motion pattern and cause systematic positioning errors [ 4 – 6 ], and AIP image is suggested to be a better alternative. In these phantom studies, different respiratory motion amplitudes and different ratios of exhale and inhale duration (EIR) were simulated to describe the irregularity of the respiratory motion.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Irregular Respiratory Motion on the Positioning Accuracy of Moving Target with Free Breathing Cone-Beam Computerized Tomography

Yorke

et al. 2018

IJMPCERO

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For positioning a moving target, a maximum intensity projection (MIP) or average intensity projection (AIP) image derived from 4DCT is often used as the reference image which is matched to free breathing cone-beam CT (FBCBCT) before treatment. This method can be highly accurate if the respiratory motion of the patient is stable. However, a patient’s breathing pattern is often irregular. The purpose of this study is to investigate the effects of irregular respiration on positioning accuracy for a moving target aligned with FBCBCT. Nine patients’ respiratory motion curves were selected to drive a Quasar motion phantom with one embedded cubic and two spherical targets. A 4DCT of the phantom was acquired on a CT scanner (Philips Brilliance 16) equipped with a Varian RPM system. The phase binned 4DCT images and the corresponding MIP and AIP images were transferred into Eclipse for analysis. FBCBCTs of the phantom driven by the same respiratory curves were also acquired on a Varian TrueBeam and fused such that both CBCT and MIP/AIP images share the same target zero positions. The sphere and cube volumes and centroid differences (alignment error) determined by MIP, AIP and FBCBCT images were calculated, respectively. Compared to the volume determined by MIP, the volumes of the cube, large sphere, and small sphere in AIP and FBCBCT images were smaller. The alignment errors for the cube, large sphere and small sphere with center to center matches between MIP and FBCBCT were 2.5 ± 1.8mm, 2.4±2.1 mm, and 3.8±2.8 mm, and the alignment errors between AIP and FBCBCT were 0.5±1.1mm, 0.3±0.8mm, and 1.8±2.0 mm, respectively. AIP images appear to be superior reference images to MIP images. However, irregular respiratory pattern could compromise the positioning accuracy, especially for smaller targets.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effects of Irregular Respiratory Motion on the Positioning Accuracy of Moving Target with Free Breathing Cone-Beam Computerized Tomography

Yorke

et al. 2018

IJMPCERO

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“…In a recent study, Wang et al . [ 51 ] also compared 3D CBCT with 4DCT MIP (segmentation based on gradient method) for ITV localization and found that the 4DCT MIP was generally larger than (10%) those obtained with CBCT. They also observed that maximum difference in centroid position was <1.4 mm between two modalities.…”

Section: S Olutions For the M Anagement mentioning

confidence: 99%

Magnitude, impact, and management of respiration-induced target motion in radiotherapy treatment: A comprehensive review

et al. 2017

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Tumors in thoracic and upper abdomen regions such as lungs, liver, pancreas, esophagus, and breast move due to respiration. Respiration-induced motion introduces uncertainties in radiotherapy treatments of these sites and is regarded as a significant bottleneck in achieving highly conformal dose distributions. Recent developments in radiation therapy have resulted in (i) motion-encompassing, (ii) respiratory gating, and (iii) tracking methods for adapting the radiation beam aperture to account for the respiration-induced target motion. The purpose of this review is to discuss the magnitude, impact, and management of respiration-induced tumor motion.

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“…To date, investigations of accuracy of respiratory-correlated fan beam versus cone beam CT imaging in the presence of respiratory motion in the ground truth setting have been limited. Researchers have compared 3DCBCT image to the 4DCT maximum intensity projection (MIP) reconstructed image of anthropomorphic respiratory phantoms and found contradictory results [25] [26]. Nevertheless,…”

Section: Sweeney Et Al Investigated Inter-observer Variability Of Tamentioning

confidence: 99%

Accuracy Comparison of 4D Computed Tomography (4DCT) and 4D Cone Beam Computed Tomography (4DCBCT)

Lee¹,

Bowen²,

James³

et al. 2017

IJMPCERO

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The ability of respiratory-correlated fan beam CT (4DCT) and respiratory-correlated cone beam CT (4DCBCT) to accurately estimate tumor volume is critical to accurate dosimetry and treatment verification for lung stereotactic body radiation therapy (SBRT) and other motion-managed therapies. However, it is known that 4DCT and 4DCBCT differ in aspects of image acquisition and reconstruction that may lead to discrepancies between the two modalities. To evaluate quantitative differences between 4DCT and 4DCBCT imaging under respiratory motion, we performed a phantom study in the ground truth setting. A programmable respiratory motion phantom was used to simulate the 1D S-I position of a known-size lesion. Ten sinusoidal and twenty patient-specific breathing waveforms were applied to drive lesion motion during the 4DCT and 4DCBCT acquisitions. The difference in lesion volume acquired between the two imaging modalities was as high as 34.4% and 18.4% for sinusoidal and patient-specific breathing motions, respectively. When compared to the true volume, 4DCT measurement often underestimated the lesion size whereas 4DCBCT overestimated the lesion volume in most of the cases. 4DCBCT gave more accurate recovery of the volume than 4DCT for most settings tested in this study. These findings may be helpful for improving the definition of internal target and planning target volume margins, and extracting quantitative information from on-board treatment verification imaging.

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Evaluation of the cone beam CT for internal target volume localization in lung stereotactic radiotherapy in comparison with 4D MIP images

Cited by 13 publications

References 48 publications

Effects of Irregular Respiratory Motion on the Positioning Accuracy of Moving Target with Free Breathing Cone-Beam Computerized Tomography

Effects of Irregular Respiratory Motion on the Positioning Accuracy of Moving Target with Free Breathing Cone-Beam Computerized Tomography

Magnitude, impact, and management of respiration-induced target motion in radiotherapy treatment: A comprehensive review

Accuracy Comparison of 4D Computed Tomography (4DCT) and 4D Cone Beam Computed Tomography (4DCBCT)

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