Evaluation of the concordance of sialometry and salivary glands scintigraphy in dry mouth patients

Abstract

It is not possible to make a choice between these tests and both should be performed.

Is minor salivary gland biopsy more than a diagnostic tool in primary Sjo¨gren׳s syndrome? Association between clinical, histopathological, and molecular features: A retrospective study

“…The Tarpley score highlights only the absence (score 0) or the presence (scores 1-4) of foci in 4 mm 2 of glandular tissue, with the higher scores identifying glands with many foci and consequent progressive derangement of glandular tissue [7]. Finally, in order to assess and quantify the presence of inflammatory cells, some authors proposed an inflammatory severity score including (i) normal MSGs (score 1), (ii) MSGs with different amounts of inflammatory cells (scores 2-4), and (iii) the presence of 1 or more foci in 4 mm 2 (score 5) [8][9][10]. The main limitations of these classical score systems is to be confined to the diagnostic setting, and H&E staining allows only to quantify the inflammatory infiltrate and foci number, without giving information concerning qualitative features of the infiltrate.…”

“…For histological evaluation, H&E-stained sections were assessed as follows: (i) the histological pattern (normal, NSCS, or FLS) [5]; (ii) the Chisholm and Mason grading system (grades 0-4) [6]; (iii) the Tarpley score (scores 0-4) [7]; (iv) a grading for the severity of inflammatory infiltrate (grades 1-5) [9,10]; and (v) the focus score, assessing the number of foci/4 mm 2 (a focus is defined as an aggregate including at least 50 mononuclear cells) [8]. A biopsy was considered GC positive (GC þ ) if displaying at least one focus with lymphoid-like organization within normal MSG tissue.…”

“…In addition to FLS, different morphologic patterns of chronic inflammation commonly occur in MSG biopsy specimens: non-specific chronic sialadenitis (NSCS) and sclerosing chronic sialadenitis (SCS) [5]. Different histological scores have been employed to describe glandular involvement during pSS [6][7][8][9][10], and as far as MSGs histology is concerned, its diagnostic role is widely accepted and currently considered the "gold standard." Indeed, MSG biopsy is considered 1 of the 4 objective criteria of American-European Consensus Group's classification and 1 of the 3 objective criteria of American College of Rheumatology's classification for pSS [11,12].…”

A Convenient and Less Invasive Technique of Labial Minor Salivary Gland Biopsy Using a Minimal Incision With a Needle Tip

“…It made an elliptical incision of oral mucous membrane down to the muscle layer [9]. After that, many modifications in a type or length of incision were reported [3,4,10,11,12,13,14,15,16,17,18,19,20,21,22]. The minor salivary gland punch biopsy was introduced in 2001 [17].…”

Immune‐mediated diseases: what can be found in the oral cavity?

“…The syndrome affects 0.5–3% of the population and clearly predominates in women (9 : 1 vs. men). The disease is usually diagnosed at about 50 years of age, though there are two peak incidences, one following menarche, the other during menopause …”