“…In addition, we found an earlier onset of macrophage polarization and the ratio of M1/M2 was lower than those reported for alginate hydrogels during the transition stage of wound inflammation to proliferation. 73 This indicates that this group had already achieved the phenotypic transition from M1-type to M2-type macrophages, smoothly transitioning into the proliferative phase. However, in the diabetic mouse group, abundant M1 macrophages were still found in the acute trauma and the commercial gel group, indicating that healing remained in the transition from the inflammatory to the proliferative phase.…”
Management of diabetic wounds presents a global health challenge due to elevated levels of ROS in the wound microenvironment, persistent dysregulation of inflammation modulation, and limitations in commercially available dressings....
“…In addition, we found an earlier onset of macrophage polarization and the ratio of M1/M2 was lower than those reported for alginate hydrogels during the transition stage of wound inflammation to proliferation. 73 This indicates that this group had already achieved the phenotypic transition from M1-type to M2-type macrophages, smoothly transitioning into the proliferative phase. However, in the diabetic mouse group, abundant M1 macrophages were still found in the acute trauma and the commercial gel group, indicating that healing remained in the transition from the inflammatory to the proliferative phase.…”
Management of diabetic wounds presents a global health challenge due to elevated levels of ROS in the wound microenvironment, persistent dysregulation of inflammation modulation, and limitations in commercially available dressings....
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