Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation

Zhang, Chaojie; Lei, Shanshan; Zhang, Zhigong; Xiao, Shuwen; Fan, Ping; Xie, Jing; Gu, Xuyu; Yang, Li; Zheng, Wei

doi:10.1007/s10147-015-0855-y

Cited by 17 publications

(18 citation statements)

References 3 publications

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“…However, Zhu et al [26] reported a study on the effect of CN on central lymph node dissection and found that the number of cases of postoperative hypocalcemia in the CN group was significantly less than that in the control group ( P = 0.013). Similar to other studies, [26,35] our study also found that CN could easily detect lymph nodes, and increased metastatic lymph nodes, and more lymph nodes were detected in the CN group than in the control group. Thus, CN might be used to achieve a more radical central neck dissection.…”

Section: Discussionsupporting

confidence: 91%

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

Zhu

et al. 2016

Medicine

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As a novel type of lymphatic tracer, carbon nanoparticles (CNs) were reported not to stain parathyroid glands (PGs) into black, so it may have a clinical potential in protection of PGs during thyroidectomy. The purpose of this study was to investigate the clinical application and significance of CN in protection of PGs from surrounding tissues.A total of 82 consecutive patients were enrolled into this study and were divided into CN group and control group. Parathyroid function (hypoparathyroidism and hypocalcemia) was evaluated.The identification rates of PGs (≤2) and PGs (≥3) were 24.4% and 75.6% in the CN group and 46.3% and 53.7% in the control group, respectively. The difference in the identification rates between the 2 groups was statistically significant (P = 0.038). Pathological results revealed 3 accidental PGs resection occurred in the CN group, whereas 9 accidental PGs removal occurred in the control group. The difference was statistically significant (P = 0.046). Moreover, the incidence of the patients with hypoparathyroidism was statistically significant between the 2 groups (36.6% in CN group vs 53.7% in control group, P = 0.043) at day 1, but not at day 7 (P = 0.424).CN may have a potential in protecting PGs clinically.

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Section: Discussionsupporting

confidence: 91%

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

Zhu

et al. 2016

Medicine

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“…Further, the blood supply can remain unchanged, preventing excessive intraoperative episodes of bleeding within the operated area. Due to the application of carbon nanoparticles as a possible method of unequivocal identification of PGs, the risk of postoperative hypothyroidism is significantly reduced [93][94][95]. Finally, the application of carbon nanoparticles provides more accurate localization of lymph nodes for further dissection during thyroidectomy and better visualization of metastatic lymph nodes [92,[96][97][98][99][100].…”

Section: Carbon Nanoparticles In Parathyroid Glands Localizationmentioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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Accurate pre-operative determination of parathyroid glands localization is critical in the selection of minimally invasive parathyroidectomy as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Its importance cannot be overemphasized as it helps to minimize the harmful side effects associated with damage to the parathyroid glands such as in hypocalcemia, severe hemorrhage or recurrent laryngeal nerve dysfunction. Preoperative and intraoperative methods decrease the incidence of mistakenly injuring the parathyroid glands and allow for the timely diagnosis of various abnormalities, including parathyroid adenomas. This article reviews 139 studies conducted between 1970 and 2020 (49 years). Studies that were reviewed focused on several techniques including application of carbon nanoparticles, carbon nanoparticles with technetium sestamibi (99m Tc-MIBI), Raman spectroscopy, near-infrared autofluorescence, dynamic optical contrast imaging, laser speckle contrast imaging, shear wave elastography, and indocyanine green to test their potential in providing proper parathyroid glands’ localization. Apart from reviewing the aforementioned techniques, this study focused on the applications that helped in the detection of parathyroid adenomas. Results suggest that applying all the reviewed techniques significantly improves the possibility of providing proper localization of parathyroid glands, and the application of indocyanine green has proven to be the ‘ideal’ approach for the diagnosis of parathyroid adenomas.

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“…As a result, reoperation for thyroid cancer was also more and more performed. [ 8 ] Because of the destroyed anatomical structure and a large amount of fibrous and scar tissues in the surgical field for the previous surgery, reoperation was very difficult and the incidence of some complications, such as parathyroid gland (PG) damage and recurrent laryngeal nerve (RLN) injury, was increasing. [ 9 – 11 ] Therefore, some methods to identify the anatomical layers and structure were necessary to avoid more injury.…”

Section: Introductionmentioning

confidence: 99%

The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma

Wang

Xing

et al. 2018

Medicine

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To evaluate the function of carbon nanoparticles during the thyroid reoperation for carcinoma, we conducted this study by retrospectively analyzing the data of patients who underwent at least completion thyroidectomy with bilateral central lymph nodes dissection for thyroid carcinoma from January 2009 to June 2016. The clinicopathologic characteristics and surgical details were compared between the patient who accepted intraoperative carbon nanoparticles injection and those who accepted nothing injection during the surgery. The main monitoring indicators were the number of dissected lymph nodes and metastatic lymph nodes in central zone, the number of identified parathyroid glands and autoplastic parathyroid glands and unintentionally resected parathyroid glands. A total of 69 patients were enrolled into the carbon nanoparticles group and 128 patients were enrolled into the control group.The average number of lymph nodes harvested in the central zone was higher in the carbon nanoparticles group than that in the control group (11.2 ± 5.7 vs 7.7 ± 4.0, P < .001), so was the average number of metastatic lymph nodes (4.5 ± 4.5 vs 2.7 ± 2.9, P = .004). The average number of identified parathyroid gland was greater in the carbon nanoparticles group than that in the control group (2.4 ± 1.2 vs 1.6 ± 1.1, P < .001). The average number of autoplastic parathyroid gland was comparable between the 2 groups (0.6 ± 0.6 vs 0.4 ± 0.7, P = .052). But the average number of unintentionally resected parathyroid gland was less in the carbon nanoparticles group than that in the control group (0.1 ± 0.2 vs 0.2 ± 0.4, P = .007). Carbon nanoparticles can improve lymph nodes dissection and identification of parathyroid gland during thyroid reoperation for carcinoma.

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Evaluation of the clinical value of carbon nanoparticles as lymph node tracer in differentiated thyroid carcinoma requiring reoperation

Cited by 17 publications

References 3 publications

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

Potential role of carbon nanoparticles in protection of parathyroid glands in patients with papillary thyroid cancer

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

The function of carbon nanoparticles to improve lymph node dissection and identification of parathyroid glands during thyroid reoperation for carcinoma

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