Evaluation of the clinical characteristics and prognostic factors of gastrointestinal mucosa‐associated lymphoid tissue (<scp>MALT</scp>) lymphoma

Xu, Xiaojun; Wang, Zhenxing; Yu, Yonghao; Zhang, Lianyu; Sun, Bei; Da, Wan-Ming; Zhang, Yizhuo

doi:10.1111/jgh.12615

Cited by 6 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Elevated LDH levels and poor ECOG PS have been correlated with shorter survival in MALT lymphomas. 34,35 Several retrospective series indicated that lymph node involvement is an important prognostic factor, and some have also suggested that the concomitant involvement of multiple mucosal sites, despite being relatively common, does not necessarily carry an unfavorable impact on outcome. 13,16,36,37 In the original IPI analysis, age was dichotomized at 60 years because this represented the eligibility cut point for myeloablative therapy and autologous stem cell transplant, which was restricted to younger patients.…”

Section: Discussionmentioning

confidence: 99%

A MALT lymphoma prognostic index

Thiéblemont

Cascione

Conconi

et al. 2017

Blood

160

124

View full text Add to dashboard Cite

There are no widely accepted prognostic indices for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). This study aimed to develop and validate a specific prognostic tool to personalize and optimize lymphoma treatment of patients with MALT lymphoma. A prognostic index was built by Cox regression (stepwise selection) using data from 401 patients enrolled in the international randomized IELSG-19 trial (NCT 00210353). A validation set, including 633 patients, was obtained by merging three independent cohorts of MALT lymphoma patients. The three individual features maintaining the greatest prognostic significance for event-free survival (EFS, the main endpoint of the IELSG-19 trial) were age ≥70 years (HR 1.72, 95% CI 1.26-2.33), Ann Arbor stage III or IV (HR 1.79, 95% CI 1.35-2.38), and elevated LDH level (HR 1.87, 95% CI 1.27-2.77). The prognostic index (MALT-IPI) constructed using these three parameters identified three groups: low, intermediate and high risk (corresponding to the presence of 0, 1 or ≥2 of these factors, respectively). The 5-year EFS rates in the low, intermediate and high risk groups were 70%, 56% and 29%, respectively. The MALT-IPI also significantly discriminated between patients with different progression-free, overall and cause-specific survival. The prognostic utility was retained in gastric and non-gastric lymphomas, in each treatment arm (chlorambucil, rituximab, rituximab plus chlorambucil), and was confirmed in the validation set. The new index, MALT-IPI, is a simple, accessible and effective tool to identify MALT lymphoma patients at risk of poor outcomes. It may help define appropriate treatment approaches for individual patients

show abstract

Section: Discussionmentioning

confidence: 99%

A MALT lymphoma prognostic index

Thiéblemont

Cascione

Conconi

et al. 2017

Blood

160

124

View full text Add to dashboard Cite

show abstract

“…H20084191) was injected into the antecubital vein at a dose of 1.5 mL/kg and a speed of 3.5 mL/s. The delayed contrast enhanced CT scan was performed at 26-180 s after the injection of the contrast [9][10][11][12]. The data of ROI were transmitted to the workstation for analysis and processing.…”

Section: Methodsmentioning

confidence: 99%

Application Value of Multi-Slice Spiral CT Multiplanar Reconstruction Technique in the Diagnosis and Clinicopathological Analysis of Gastrointestinal Lymphoma

Yu¹,

Zou²

2021

Oncologie

View full text Add to dashboard Cite

Objective: The purpose was to explore the value of multi-slice spiral CT (MSCT) multiplanar reconstruction technique in the diagnosis and clinicopathological analysis of gastrointestinal lymphoma (GIL). Methods: 82 GIL patients treated in our hospital from February 2018 to February 2019 were selected as the experimental group of this study, and 82 patients with other gastrointestinal tumors diagnosed by pathology during the same period were selected as the control group. Both groups of patients were scanned by MSCT and analyzed by multiplanar reconstruction technique to compare the diagnostic results and clinicopathological indexes of the two groups. Results: The diagnostic accuracy of MSCT multiplanar reconstruction scanning was higher, with no statistical difference from that of pathological examination results (P > 0.05). Compared with the control group, the objective image noise of the experimental group was lower while the signal-to-noise ratio (SNR) was higher, with significant differences between the two groups (P < 0.05). There were statistically significant differences in the CT reconstruction parameters of different tumor types and different clinical stages in the experimental group (P < 0.05). Conclusion: MSCT multiplanar reconstruction technique is effective in diagnosing GIL, and the CT reconstruction parameters have important guiding value for the differentiation of tumor tissue types and clinical stages. The technique enables the doctors to fully grasp the clinical manifestations of the disease and select appropriate therapeutic regimens, improving the diagnostic accuracy and prognostic effect of the disease, which is worthy of wide application and promotion in clinic.

show abstract

“…The identification of validated prognostic factors is an important tool in MALT lymphoma because of their potential impact on survival and management. Several baseline variables have been shown to have prognostic relevance including age, gender, stage, international prognostic index (IPI) score, 8 lactate dehydrogenase (LDH) level, 9,10 immunohistochemical molecules 11 (FOXP1, p53, and BCL2), and localization of MALT lymphoma 12 ; however, most of these have not been validated in studies with large cohorts of patients and remain controversial. Recently, Theiblemont et al 13 generated a MALT prognostic index from the dataset of the IELSG-19 trial; they identified elevated serum β2-microglobulin levels, the presence of B symptoms (fever, night sweats, and weight loss), and male sex as prognostic factors for recurrence-free survival and overall survival (OS).…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of baseline ¹⁸F‐FDG PET/CT parameters in MALT lymphoma

Albano

Bosio

Camoni

et al. 2018

Hematological Oncology

View full text Add to dashboard Cite

Mucosa‐associated lymphoid tissue (MALT) lymphoma is an indolent lymphoma with good prognosis and variable fluorine‐18 fluorodeoxyglucose (18F‐FDG) avidity. Many possible prognostic factors have been investigated with controversial results, but the possible prognostic role of 18F‐FDG positron emission tomography/computed tomography (PET/CT) remains unclear. Our aim was to evaluate the prognostic impact of qualitative and semiquantitative baseline PET/CT parameters on outcome of MALT lymphoma. We retrospectively enrolled 161 patients with histologically confirmed MALT lymphoma who underwent 18F‐FDG PET/CT before any treatment. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). The Kaplan‐Meier method was used to estimate the progression‐free survival (PFS) and overall survival (OS) times. Cox regression models were performed to determine the relation between PET/CT features and OS and PFS. Ninety‐eight patients had positive 18F‐FDG PET/CT showing 18F‐FDG uptake (mean SUVbw, 10.1; SUVlbm, 7.2; SUVbsa, 2.7; MTV, 88.8; and TLG, 526); the remaining 63 were not 18F‐FDG avid. 18F‐FDG avidity was significantly correlated with tumor size and Ki‐67 score. Relapse/progression of disease occurred in 47 patients with an average time of 40.2 months; death occurred in 12 patients with an average of 59 months. At a median follow‐up of 62 months, median PFS and OS were 52 and 62 months, respectively. Advanced tumor stage and extragastric site were demonstrated to be independent prognostic factors for PFS, while only tumor stage for OS. Instead, PET/CT parameters were not related to survival, despite positive correlation at univariate analysis between MTV and TLG with PFS and positive PET/CT with PFS and OS. In conclusion, a 61% rate of PET avidity in biopsy‐confirmed MALT lymphoma was found, and it was correlated with tumor size and Ki‐67 score. Only tumor stage and localization were independently correlated with PFS and OS.

show abstract

Evaluation of the clinical characteristics and prognostic factors of gastrointestinal mucosa‐associated lymphoid tissue (MALT) lymphoma

Abstract: The clinical characteristics and outcomes demonstrated no significant differences between gastric and intestinal tract MALT lymphomas. Serum lactate dehydrogenase level was an independent prognostic factor for the survival of GI MALT lymphoma.

Cited by 6 publications

References 27 publications

A MALT lymphoma prognostic index

A MALT lymphoma prognostic index

Application Value of Multi-Slice Spiral CT Multiplanar Reconstruction Technique in the Diagnosis and Clinicopathological Analysis of Gastrointestinal Lymphoma

Prognostic role of baseline ¹⁸F‐FDG PET/CT parameters in MALT lymphoma

Contact Info

Product

Resources

About

Evaluation of the clinical characteristics and prognostic factors of gastrointestinal mucosa‐associated lymphoid tissue (MALT) lymphoma

Abstract: The clinical characteristics and outcomes demonstrated no significant differences between gastric and intestinal tract MALT lymphomas. Serum lactate dehydrogenase level was an independent prognostic factor for the survival of GI MALT lymphoma.

Cited by 6 publications

References 27 publications

A MALT lymphoma prognostic index

A MALT lymphoma prognostic index

Application Value of Multi-Slice Spiral CT Multiplanar Reconstruction Technique in the Diagnosis and Clinicopathological Analysis of Gastrointestinal Lymphoma

Prognostic role of baseline 18F‐FDG PET/CT parameters in MALT lymphoma

Contact Info

Product

Resources

About

Prognostic role of baseline ¹⁸F‐FDG PET/CT parameters in MALT lymphoma