Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy

Tafaghodi, Mohsen; Tabassi, Sayyed Abolghasem Sajadi; Jaafari, M. R.; Zakavi, Seyed Rasoul; Momen-nejad, Mahdi

doi:10.1016/j.ijpharm.2004.05.009

Cited by 67 publications

(20 citation statements)

References 46 publications

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“…Nonparenteral drug administration has been shown to be effective for systemic drug delivery (1). The nasal route of drug delivery has advantages over the other alternative systems of non-invasive drug administration (2,3). Nasal administrations may be a promising route for long-term systemic delivery particularly when the drug is ineffective orally due to first-pass metabolism.…”

Section: Introductionmentioning

confidence: 99%

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

et al. 2008

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Abstract. The purpose of this research was to develop an emulsion formulation of indomethacin (IND) suitable for nasal delivery. IND was incorporated into the oil phases of oil in water (O/W) and water in oil (W/O) emulsions. For this purpose, different emulsifying agents (Tween 80, Span 80 and Brij 58) were used in two emulsion formulations. When the effects of several synthetic membranes (nylon, cellulose, cellulose nitrate) were compared with the sheep nasal mucosa, the cellulose membrane and sheep nasal mucosa showed similar permeation properties for O/W emulsion (P > 0.05). To examine the absorption characteristics of IND, the anti-inflammatory properties of intravenous solution of IND, intranasal O/W emulsions of IND (with or without enhancers) and intranasal solution of IND (IND-Sol) were investigated in rats with carrageenan-induced paw edema. When citric acid was added to the nasal emulsion, the anti-inflammatory activity was similar to that of intravenous solution (P > 0.05). Finally, it was concluded that, intranasal administration of IND emulsion with citric acid may be considered as an alternative to intravenous and per oral administrations of IND to overcome their adverse effects.

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Section: Introductionmentioning

confidence: 99%

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

et al. 2008

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“…Although our experiments were restricted to sampling fungi that had been deposited after natural environmental exposure, we can relate our findings to studies performed using radiolabelled particulate matter of a size and density approximating that of fungal spores. Radiolabelled alginate and Sephadex microspheres (1.3 and 24.6 lm in diameter, respectively) inhaled on to the human nasal mucosa had clearance half-lives of 4 h and 2 h, respectively (Tafaghodi, Abolghasem Sajadi Tabassi, Jaafari, Zakavi, & Momen-Nejad, 2004). For particles of a size equivalent to small fungal spores, 12.5% of the particles inhaled may therefore remain on the nasal mucosa 12 h after inhalation.…”

Section: Discussionmentioning

confidence: 99%

Recovery of germinating fungal conidia from the nasal cavity after environmental exposure

2006

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Background The expression of fungal allergens is increased by the germination of conidia. We assessed the state of germination of fungal conidia recovered by nasal lavage after environmental exposure. Methods Nasal lavage was performed on twenty adults at three stages: the start of the experiment, after 1 h indoors, and after 1 h outdoors. One half of the lavage liquid was immediately treated to prevent in-vitro germination and stained with periodic acid Schiff (PAS) to enable identification of germinated and ungerminated conidia. The untreated half of the lavage liquid was cultured on nutrient agar plates to enumerate and identify viable fungi.Results PAS staining showed that both ungerminated and germinated conidia, and hyphal fragments, were present in the nasal cavity. The most prevalent fungi recovered were Aspergillus, Alternaria, Cladosporium, Epicoccum, Penicillium, and Yeast species. The number of viable fungi recovered after 1 h indoors was significantly less than after 1 h outdoors (P < 0.01).Conclusions Viable fungi and germinating conidia, in addition to ungerminated conidia and hyphal fragments, were present in the nasal cavity after both indoor and outdoor exposure. This provides novel insight into the pathogenicity of exposure to fungal aeroallergens.

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“…The nasal mucociliary clearance is inversely proportional to the bioavailability of drug compounds after nasal administration, i.e. higher the nasal secretion rate and faster the ciliary movement results in lower nasal bioavailability (Merkus et al, 2001;Soane et al, 2001;Tafaghodi et al, 2004;Illum, 2006;Boogaard et al, 2007). Formulation approaches are employed to overcome the effect of these physiological factors, for example, utilization of water miscible non-nauseating NGs and the use of anesthetic in minute quantity in the formulation (Nazar et al, 2011).…”

Section: Challenges Related To Physiological and Pathological Aspectsmentioning

confidence: 99%

Nasal-nanotechnology: revolution for efficient therapeutics delivery

2014

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Context: In recent years, nanotechnology-based delivery systems have gained interest to overcome the problems of restricted absorption of therapeutic agents from the nasal cavity, depending upon the physicochemical properties of the drug and physiological properties of the human nose. Objective: The well-tolerated and non-invasive nasal drug delivery when combined with the nanotechnology-based novel formulations and carriers, opens the way for the effective systemic and brain targeting delivery of various therapeutic agents. To accomplish competent drug delivery, it is imperative to recognize the interactions among the nanomaterials and the nasal biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signaling involved in patho-biology of the disease under consideration. Methods: Quite a few systems have been successfully formulated using nanomaterials for intranasal (IN) delivery. Carbon nanotubes (CNTs), chitosan, polylactic-co-glycolic acid (PLGA) and PLGA-based nanosystems have also been studied in vitro and in vivo for the delivery of several therapeutic agents which shown promising concentrations in the brain after nasal administration. Results and conclusion: The use of nanomaterials including peptide-based nanotubes and nanogels (NGs) for vaccine delivery via nasal route is a new approach to control the disease progression. In this review, the recent developments in nanotechnology utilized for nasal drug delivery have been discussed.

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Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy

Cited by 67 publications

References 46 publications

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

Permeation Studies of Indomethacin from Different Emulsions for Nasal Delivery and Their Possible Anti-Inflammatory Effects

Recovery of germinating fungal conidia from the nasal cavity after environmental exposure

Nasal-nanotechnology: revolution for efficient therapeutics delivery

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