Evaluation of the circulating serum endotrophin in women with and without gestational diabetes mellitus during second trimester

Prediction of gestational diabetes mellitus: are we ready for a biomarker lead screening strategy for GDM?

“…Guleroglu et al [13] reported significant differences in oxidative stress markers as well as markers of oxidative DNA damage and proapoptosis in 69 GDM women with 21-42 weeks gestation when compared with those with non-GDM pregnant women. Similarly, Argun et al [14] have shown significantly higher levels of endotrophin, a newly discovered adipocytokine, in second-trimester GDM subjects compared to those in normal pregnant women which correlated well with fasting and 1-h post-OGTT glucose values and HOMA-IR. Yang et al [15] from China demonstrated a low-grade inflammatory state in a small set of diagnosed GDM women who were shown to have significantly higher levels of IL2, IL6, and hsCRP than non-GDM pregnant women.…”