Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Zhang, Huijuan; Yin, Meng; Huang, Lianyan; Wang, Jing; Sun, Baoguo

doi:10.1111/1750-3841.13605

Cited by 40 publications

(35 citation statements)

References 128 publications

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“…It is also good complementary information in addition to the ABTS-based antioxidant measurement. Indeed, it helps to underline mechanisms in complex systems; to be effective, the antioxidants need to be absorbed, transported, distributed, and retained properly in the biological fluids, cells, and tissues [41]. In addition, to be used in food, medicine, or cosmetics, the antioxidant molecule must be safe/non-toxic.…”

Section: Discussionmentioning

confidence: 99%

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Carboué¹,

Maresca

Herbette

et al. 2019

Biomolecules

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Seven naphtho-gamma-pyrones (NγPs), including asperpyrone E, aurasperone A, dianhydroaurasperone C, fonsecin, fonsecinone A, fonsecin B, and ustilaginoidin A, were isolated from Aspergillus tubingensis G131, a non-toxigenic strain. The radical scavenging activity of these NγPs was evaluated using ABTS assay. The Trolox equivalent antioxidant capacity on the seven isolated NγPs ranged from 2.4 to 14.6 μmol L−1. The toxicity and ability of the NγPs to prevent H2O2-mediated cell death were evaluated using normal/not cancerous cells (CHO cells). This cell-based assay showed that NγPs: (1) Are not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an IC50 on H2O2-mediated cell death ranging from 2.25 to 1800 μmol mL−1. Our data show that A. tubingensis G131 strain is able to produce various NγPs possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries.

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Section: Discussionmentioning

confidence: 99%

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Carboué¹,

Maresca

Herbette

et al. 2019

Biomolecules

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“…Antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) are synthesized in the body and provide protection from reactive oxygen species generated during heat stress (Gupta et al, 2013). These antioxidants scavenge both intracellular and extracellular super oxides and inhibit lipid peroxidation of plasma membrane (Zhang, et al, 2017). Chaudhary et al (2015) reported a significantly higher level of plasma malondialdehyde, SOD and GPx activities in Surti buffaloes during hot humid periods and hot dry periods indicating an increased free radical production during periods of heat stress.…”

Section: Blood Biochemical Responsementioning

confidence: 99%

Review: Adaptation of animals to heat stress

Sejian

Bhatta

Gaughan

et al. 2018

Animal

321

206

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Livestock plays an important role in the global economy. Climate change effects are not only limited to crop production, but also affect livestock production, for example reduced milk yields and milk quality, reduced meat production and reduced fertility. Therefore, livestock-based food security is threatened in many parts of the world. Furthermore, multiple stressors are a common phenomenon in many environments, and are likely to increase due to climate change. Among these stresses, heat stress appears to be the major factor which negatively influences livestock production. Hence, it is critical to identify agro-ecological zone-specific climate resilient thermo-tolerant animals to sustain livestock production. Livestock responds to the changing environments by altering their phenotypic and physiological characters. Therefore, survivability of the animal often depends on its ability to cope with or adapt to the existing conditions. So to sustain livestock production in an environment challenged by climate change, the animals must be genetically suitable and have the ability to survive in diversified environments. Biological markers or biomarkers indicate the biological states or alterations in expression pattern of genes or state of protein that serve as a reference point in breeding for the genetic improvement of livestock. Conventionally, identification of animals with superior genetic traits that were economically beneficial was the fundamental reason for identifying biomarkers in animals. Furthermore, compared with the behavioural, morphological or physiological responses in animals, the genetic markers are important because of the possibility of finding a solution to animal adaptability to climate change.

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“…27 Tissue MDA and GSH-Px levels and SOD activity are indices of oxidative stress and lipid peroxidation, as well as of free radical clearance and antioxidant capacity. [28][29][30][31] Compared to the untreated HLP rats (Fig. 5), ARFE-H rats have signicantly higher SOD activity (P < 0.05), and lower GSH-Px levels (P < 0.05).…”

Section: Liver Sod Mda and Gsh-px Analysismentioning

confidence: 92%

Lipid-lowering and antioxidative effects ofApium graveolensL. root flavonoid extracts

Shi

Zhang

et al. 2019

RSC Adv.

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Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review

Cited by 40 publications

References 128 publications

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Naphtho-Gamma-Pyrones Produced by Aspergillus tubingensis G131: New Source of Natural Nontoxic Antioxidants

Review: Adaptation of animals to heat stress

Lipid-lowering and antioxidative effects ofApium graveolensL. root flavonoid extracts

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