Evaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis

Luciani, A; Sconza, Sarah; Civitella, Carla; Guglielmini, Carlo

doi:10.1016/j.tvjl.2012.08.013

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…197 Recent investigations demonstrated that no toxic effects on cardiac or pancreatic tissue are induced by these drug classes in dogs, differently from what is observed in human patients. 198,199 Therefore, toxic effects should be monitored only in selected dogs, particularly when peculiar clinical findings are present or history might suggest any drug adversity.…”

Section: Tests For Monitoring the Posttreatment Follow-upmentioning

confidence: 99%

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

143

232

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Although several reviews on canine leishmaniasis have been published, none thoroughly described clinicopathologic abnormalities and their clinical usefulness. The aim of this review was to provide information concerning current diagnostic tests relevant for clinical pathologists and from a practical perspective. Specifically, in canine leishmaniasis, nonregenerative normocytic normochromic anemia, thrombocytopenia, or leukogram changes may be present. Clinical chemistry and urinalysis may indicate renal dysfunction (azotemia, decreased urine specific gravity, proteinuria) and an inflammatory/immune response (increased acute phase proteins [APP] or α - and/or γ-globulins). Although a potential gammopathy is usually polyclonal, it may also appear oligo- or monoclonal, especially in dogs coinfected by other vector-borne pathogens. When lesions are accessible to fine-needle aspiration (lymphoadenomegaly, nodular lesions, joint swelling), cytology is strongly advised, as the presence of Leishmania amastigotes in a pattern of pyogranulomatous inflammation or lymphoplasmacytic hyperplasia is diagnostic. If the cytologic pattern is inconclusive, the parasite should be identified by histology/immunohistochemistry or PCR on surgical biopsies. Alternatively, cytology and PCR may be performed on bone marrow samples where amastigotes, along with erythroid hypoplasia, myeloid hyperplasia, plasmacytosis, or secondary dysmyelopoiesis can be observed. Dogs with overt leishmaniasis generally have high antibody titers, while low titers predominate in immunologically resistant infected dogs or in exposed dogs with no parasite confirmation. Quantitative serology is recommended in clinically suspect dogs as high-titer antibodies titers may confirm the clinical diagnosis. In confirmed and treated dogs, renal function and inflammatory/immune response variables should be periodically monitored.

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Section: Tests For Monitoring the Posttreatment Follow-upmentioning

confidence: 99%

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Paltrinieri

Gradoni

Roura

et al. 2016

Veterinary Clinical Pathol

143

232

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“…A research has evaluated the cardiotoxic effects of meglumine antimoniate for 60 days at therapeutic dosage in dogs with leishmaniasis, and it revealed that there was no demonstration in cTnI dosage or electrocardiographic characteristics of cardiac damage ( 61 ).…”

Section: Traditional Laboratory Testmentioning

confidence: 99%

Canine Traditional Laboratory Tests and Cardiac Biomarkers

Gavazza

Fruganti

Turinelli³

et al. 2020

Front. Vet. Sci.

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“…Those latter alterations were suggestive of enlargements of left atrium/ ventricle and myocardial hypoxia (20). Another study evaluated the cardiotoxic changes in relation with pentavalent antimonial compounds in CVL (23). Twenty-eight dogs naturally infected with Leishmania infantum were treated with proteinúricos en comparación con perros no proteínicos con CVL.…”

Section: 000mentioning

confidence: 99%

“…Otro estudio evaluó los cambios cardiotóxicos en relación con los compuestos antimoniales pentavalentes en CVL (23). Veintiocho perros naturalmente infectados con Leishmania infantum fueron tratados con antimoniato de meglumina y se determinó un examen de ECG antes y después del tratamiento, en el que no se detectaron anomalías en los trazos de ECG (23).…”

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Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

et al. 2017

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Objective. The purpose of the present study was to test the hypothesis that cardiac alterations participate within different stages of CVL. Materials and methods. Twenty-eight dogs were diagnosed with CVL, were classified [based on clinical signs, rapid ELISA/IFAT, hematological and serum biochemical tests, urinary protein/creatinine ratio, ECG and ECHO]. as follows; group I (mild disease), group II (moderate disease), group III (severe disease), group IV (very severe disease) and group V included healthy controls. Results. Ig G antibodies against leishmaniasis as tested by IFAT, were deemed 1/64 to 1/16000 among infected groups. There were statistical significance regarding mean values for WBC [among healthy control group (V.) and other groups (p=0. No hubo alteración en las concentraciones de CTnI, entre los grupos. El análisis de UPC reveló diferencia estadística entre el grupo control y los perros de estadio II a IV (p=0.000). Se detectaron alteraciones ECG moderadas o severas en 6/28 de los perros enfermos. En cuanto al examen ECHO, el valor LA / Ao presentó diferencias significativas (p=0.003) entre los grupos IV y otros. Conclusiones. Se puede sugerir que el establecimiento del Grupo de Trabajo de Leishvet a los de los perros clasificados en estadios I a IV, ECG [aumento de la aurícula / ventrículo izquierdo, hipoxia miocárdica] y ECHO [dilatación auricular izquierda, disminución / aumento de los LVID, Y la EF (disfunción sistólica)] alteraciones deben tomarse en cuenta junto con el análisis hematológico y bioquímico del suero.

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Evaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis

Cited by 11 publications

References 10 publications

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Laboratory tests for diagnosing and monitoring canine leishmaniasis

Canine Traditional Laboratory Tests and Cardiac Biomarkers

Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

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