Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats

Bondarenko, Stanislav; Ashukina, Nataliya; Maltseva, Valentyna; Ivanov, G; Badnaoui, Ahmed; Schwarzkopf, Ran

doi:10.1186/s13018-020-01822-3

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Different studies showed the beneficial effects of titanium implants [62,63] and biomimetic composites based on hydroxyapatite [64,65], hydroxyapatite substituted with strontium [66] or dicalcium phosphate [67] in facilitating peri-implant bone formation and anchoring the implant to the surrounding bone tissue, which increases the stability and osseointegration. Micro-CT results, together with histological analysis, bone markers, AFM and FE-SEM evaluation, produced valuable and relevant information regarding the osseointegration of the metallic implants [68].…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Composite Coatings for Activation of Titanium Implant Surfaces: Methodological Approach and In Vivo Enhanced Osseointegration

et al. 2021

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Innovative nanomaterials are required for the coatings of titanium (Ti) implants to ensure the activation of Ti surfaces for improved osseointegration, enhanced bone fracture healing and bone regeneration. This paper presents a systematic investigation of biomimetic composite (BC) coatings on Ti implant surfaces in a rat model of a diaphyseal femoral fracture. Methodological approaches of surface modification of the Ti implants via the usual joining methods (e.g., grit blasting and acid etching) and advanced physicochemical coating via a self-assembled dip-coating method were used. The biomimetic procedure used multi-substituted hydroxyapatite (ms-HAP) HAP-1.5 wt% Mg-0.2 wt% Zn-0.2 wt% Si nanoparticles (NPs), which were functionalized using collagen type 1 molecules (COL), resulting in ms-HAP/COL (core/shell) NPs that were embedded into a polylactic acid (PLA) matrix and finally covered with COL layers, obtaining the ms-HAP/COL@PLA/COL composite. To assess the osseointegration issue, first, the thickness, surface morphology and roughness of the BC coating on the Ti implants were determined using AFM and SEM. The BC-coated Ti implants and uncoated Ti implants were then used in Wistar albino rats with a diaphyseal femoral fracture, both in the absence and the presence of high-frequency pulsed electromagnetic shortwave (HF-PESW) stimulation. This study was performed using a bone marker serum concentration and histological and computer tomography (micro-CT) analysis at 2 and 8 weeks after surgical implantation. The implant osseointegration was evaluated through the bone–implant contact (BIC). The bone–implant interface was investigated using FE-SEM images and EDX spectra of the retrieved surgical implants at 8 weeks in the four animal groups. The obtained results showed significantly higher bone–implants contact and bone volume per tissue volume, as well as a greater amount of newly formed bone, in the BC-coated Ti implants than in the uncoated Ti implants. Direct bone–implant contact was also confirmed via histological examination. The results of this study confirmed that these biomimetic composite coatings on Ti implants were essential for a significant enhancement of osseointegration of BC-coated Ti implants and bone regeneration. This research provides a novel strategy for the treatment of bone fractures with possible orthopedic applications.

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Section: Discussionmentioning

confidence: 99%

Biomimetic Composite Coatings for Activation of Titanium Implant Surfaces: Methodological Approach and In Vivo Enhanced Osseointegration

et al. 2021

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“…Зокрема, у жінок із постменопаузальним остеопорозом і пацієнтів із ревматоїдним артритом підтверджено високий рівень у крові TGF-β [49], прозапального цитокіна, який активує диференціацію остеокластів із попередників через RANKL та призводить до підвищення процесу резорбції кістки [50]. В експериментальних дослідженнях порівняно різні види пористих металевих матеріалів, які використовують для виготовлення ацетабулярних компонентів за умов нормальної кісткової тканини [51][52][53] та в разі моделювання остеопорозу шляхом оваріоектомії [54][55][56]. Доведено високі остеоінтегративні якості різновидів пористих титану і танталу.…”

Section: перебудова кісткової тканини навколо ендопротеза кульшового суглоба після хірургічного втручанняunclassified

“…Доведено високі остеоінтегративні якості різновидів пористих титану і танталу. Проте формування кістки та показник остеоінтеграції цих матеріалів були нижчими в разі моделювання остеопорозу, ніж у тварин із нормальною будовою кістки [54,55], а найбільші руйнівні навантаження витримувала кісткова тканина з імплантатами з пористого танталу [56]. Також опубліковані роботи щодо використання титанових матеріалів для дентальної імплантології в експериментах на моделі з дефіцитом естрогенів (модель остеопорозу/ остеопенії) та показано, що за цих умов пригнічується формування губчастої кісткової тканини навколо імплантата в терміни 4-24 тижні після встановлення [57][58][59][60].…”

Particularities of hip arthroplasty and restoration of its function in patients with low bone mass (literature review)

Filipenko¹,

Bondarenko²,

Badnaoui³

et al. 2021

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Objective. Basing on the analysis of the scientific literature to study the prevalence of osteoporosis and osteopenia among patients with hip osteoarthritis undergoing THA and to establish the influence of osteoporosis/osteopenia on the choice of implants and on the restoration of the joint function after the surgery. Osteoporosis and osteopenia are manifested in 21-32 % patients undergoing hip arthroplasty. Low bone mass may be a cause of intraoperative (periprosthetic hip fractures) and postoperative complications. In patients with low bone mass bone remodeling with an increased resorption and inhibition of bone formation around hip components can lead to increasing of its micro-movements, the formation of fibrous tissues, and diminution of implants survivorship. In patients with normal bone mineral density (BMD) also the loss of bone tissue around the acetabular cup can occur; it can occur up to 20-60 % in the first three years post operation, which can lead to the cup instability. But the dynamics of changes in bone tissue around the acetabular component in patients with osteoporosis/osteopenia is nowadays poorly understood. We suppose that porous acetabular components have advantages in patients with low BMD. Due to the elastic modulus which is closely similar to cancellous bone, as well as the corresponding porosity, which facilitates osteointegration and gives a reliable secondary biological fixation of the acetabulum. Rehabilitation and restoration of kinematic and support function of the hip joint after arthroplasty is an important issue for patients with low BMD. Gait disturbance can persist 12 months after surgery. One of the reasons is the weakness of the muscles of the femur. Rehabilitation after total hip arthroplasty leads to faster recovery, but particularities of rehabilitation in patients with low bone mass are not fully studied.

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“…In a previous experimental animal study utilizing a rat model, it was shown that osseointegration of current porous acetabular implant materials, as well as the possibility of successful implantation and osseointegration in osteoporotic bone, directly depends on the structural characteristics of the porous implant[ 9 ]. However, there is a lack of comparative data of the strength and stability of the bonе-metal osseointegration of current porous materials used in acetabular components in both normal and in osteoporotic bones.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits: A biomechanical study

Bondarenko

Filipenko

Karpinsky

et al. 2021

WJO

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BACKGROUND Today, biological fixation of uncemented press-fit acetabular components plays an important role in total hip arthroplasty. Long-term stable fixation of these implants depends on the osseointegration of the acetabular cup bone tissue into the acetabular cup implant, and their ability to withstand functional loads. AIM To compare the strength of bone-implant osseointegration of four types of porous metal implants in normal and osteoporotic bone in rabbits. METHODS The study was performed in 50 female California rabbits divided into non-ovariectomized (non-OVX) and ovariectomized groups (OVX) at 6 mo of age. Rabbits were sacrificed 8 wk after the implantation of four biomaterials [TTM, CONCELOC, Zimmer Biomet's Trabecular Metal (TANTALUM), and ATLANT] in a 5-mm diameter defect created in the left femur. A biomechanical evaluation of the femur was carried out by testing implant breakout force. The force was gradually increased until complete detachment of the implant from the bone occurred. RESULTS The breakout force needed for implant detachment was significantly higher in the non-OVX group, compared with the OVX group for all implants (TANTALUM, 194.7 ± 6.1 N vs 181.3 ± 2.8 N; P = 0.005; CONCELOC, 190.8 ± 3.6 N vs 180.9 ± 6.6 N; P = 0.019; TTM, 186.3 ± 1.8 N vs 172.0 N ± 11.0 N; P = 0.043; and ATLANT, 104.9 ± 7.0 N vs 78.9 N ± 4.5 N; P = 0.001). In the OVX group, The breakout forces in TANTALUM, TTM, and CONCELOC did not differ significantly ( P = 0.066). The breakout force for ATLANT in the OVX group was lower by a factor of 2.3 compared with TANTALUM and CONCELOC, and by 2.2 compared with TTM ( P = 0.001). In the non-OVX group, the breakout force for ATLANT was significantly different from all other implants, with a reduction in fixation strength by a factor of 1.9 ( P = 0.001). CONCLUSION TANTALUM, TTM, and CONCELOC had equal bone-implant osseointegration in healthy and in osteoporotic bone. ATLANT had significantly decreased osseointegration ( P = 0.001) in healthy and in osteoporotic bone.

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Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats

Cited by 8 publications

References 40 publications

Biomimetic Composite Coatings for Activation of Titanium Implant Surfaces: Methodological Approach and In Vivo Enhanced Osseointegration

Biomimetic Composite Coatings for Activation of Titanium Implant Surfaces: Methodological Approach and In Vivo Enhanced Osseointegration

Particularities of hip arthroplasty and restoration of its function in patients with low bone mass (literature review)

Osseointegration of porous titanium and tantalum implants in ovariectomized rabbits: A biomechanical study

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