Evaluation of the bisphenol A-induced vascular toxicity on human umbilical artery

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

“…Exposure to BPA can modulate the vasorelaxant response of the Human umbilical artery (HUA) by affecting key pathways such as NO/cyclic Guanosine monophosphate (cGMP)/soluble Guanylate cyclase (sGC)/Protein kinase G (PKG). Recent research revealed decreased expression of Human umbilical artery smooth muscle cells (HUASMC) and increased expression of the BKCa channel β1 subunit as a result of BPA exposure [ 46 ].…”