Evaluation of the biochemical, inflammatory and oxidative profile of obese patients given clinical treatment and bariatric surgery

Schmatz, Roberta; Bitencourt, Mariana Rechia; Patias, Luciana; Beck, Maristela de Oliveira; Alvarez, Glauco da Costa; Zanini, Daniela; Gutierres, Jessié Martins; Diehl, Lia Natália; Pereira, Luciane Belmonte; Leal, Cláudio A.M.; Duarte, Marta Frescura; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria

doi:10.1016/j.cca.2016.12.012

Cited by 56 publications

(40 citation statements)

References 47 publications

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“…23 Moreover, it has been shown that after bariatric surgery, there is a reduction in infl ammatory markers such as alpha1-acid glycoprotein, monocyte chemoattractant protein-1, tumour necrosis factor-alpha and C-reactive protein, as well as in oxidative stress markers such as malondialdehyde, superoxide dismutase, catalase, glutathione and disulphide. 24,25 Interestingly, parallel to these physiological adaptations, microbiota profi le alterations after bariatric surgery could also affect the physio-metabolic variations of the patient. 26 Targeting metabolic syndrome by bariatric surgery Not all patients are eligible for bariatric surgery as most procedures restructure gastrointestinal physiology therefore it may permanently affect normal metabolism.…”

Section: Bariatric Surgerymentioning

confidence: 99%

Bariatric Surgery as a Treatment for Metabolic Syndrome

Cordero

Oben

2017

Journal of the Royal College of Physicians of Edinburgh

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Obesity is the pandemic of the 21st century. Obesity comorbidities, including hypertension, dyslipidaemia and glucose intolerance de ne metabolic syndrome, which increases mortality risk and decreases the quality of life. Compared with lifestyles (diet and physical activity) and pharmacological interventions, bariatric surgery is by far the most effective treatment for obesity and its comorbidities. This minimally invasive surgical treatment is based on an increase of satiety (by hormonal regulation and decreasing stomach volume) or a decrease in nutrient retention (gastric and/or intestinal resection). Bariatric surgery has widely demonstrated a bene cial effect on excess body weight loss, cardiovascular risk, dyslipidaemia, non-alcoholic fatty liver disease or glucose homeostasis, among other obesity-related metabolic diseases. This review describes current efforts for the implementation of bariatric surgery in metabolic syndrome, which are mainly focused on the formulation of key de nition criteria for targeting the most suitable population for this therapeutic approach. Patients should undergo appropriate nutritional and psychological follow up in order to achieve and maintain weight loss milestones and a healthy metabolic status.Keywords: bariatric surgery, diabetes, dyslipidaemia, hypertension, metabolic syndrome, obesity Declaration of interests: No confl ict of interests declared AbstractIntroduction

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Section: Bariatric Surgerymentioning

confidence: 99%

Bariatric Surgery as a Treatment for Metabolic Syndrome

Cordero

Oben

2017

Journal of the Royal College of Physicians of Edinburgh

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“…While insulin levels return back to normal rates within days after bariatric surgery, it takes many months to recover insulin resistance as well as inflammation and oxidative stress in adipose tissue [18,19,20]. Five studies have focused on the effect of bariatric surgery on oxidative stress [40,41,42,48,50]. …”

Section: Resultsmentioning

confidence: 99%

“…We identified 15 studies investigating the effect of weight loss interventions (diet- and/or exercise-, and surgery-induced) on individuals' oxidative stress level (table 1): 6 RCTs and 9 non-randomized intervention studies (n = 5 diet, n = 6 diet and/or exercise interventions, and n = 3 bariatric surgery interventions) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48].…”

Section: Resultsmentioning

confidence: 99%

“…All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. …”

Section: Resultsmentioning

confidence: 99%

“…One recent study was conducted in 60 obese women and men [48]. 40 patients (n = 20 diabetic, n = 20 non-diabetic) underwent bariatric surgery, and 20 patients received clinical treatment [48].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

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Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

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Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants

Santos¹,

Sinha²

2023

Subcellular Biochemistry

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Evaluation of the biochemical, inflammatory and oxidative profile of obese patients given clinical treatment and bariatric surgery

Cited by 56 publications

References 47 publications

Bariatric Surgery as a Treatment for Metabolic Syndrome

Bariatric Surgery as a Treatment for Metabolic Syndrome

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants

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