Evaluation of the Autonomic Nervous System in a Canine Model of Chronic Embolic Pulmonary Hypertension

Ogawa, Mizuki; Ishizaka, Mio; Akabane, Ryota; Sakatani, Atsushi; Nagakawa, Masayoshi; Miyakawa, Hirosumi; Miyagawa, Yuichi; Takemura, Naoyuki

doi:10.1007/s11259-020-09774-z

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…SDNN and RMSSD are used as indicators of the degree of HRV, while pNN50 indicates vagal nerve activity. 23 The HF parameter is used as an indicator of vagal nerve activity and LF is used to indicate sympathetic and vagal nerve activity. 31,32 Thus, these indicate an increase in sympathetic nerve activity and/or a decrease in vagal nerve activity.…”

Section: Discussionmentioning

confidence: 99%

“…The behaviour of the cats at feeding time was indicative of an excited state. SDNN and RMSSD are used as indicators of the degree of HRV, while pNN50 indicates vagal nerve activity 23 . The HF parameter is used as an indicator of vagal nerve activity and LF is used to indicate sympathetic and vagal nerve activity 31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, HR and HR variability (HRV) are used to estimate autonomic nervous system function. 23 The HR is continually regulated by the action of the pacemaker while the sympathetic and vagal nerves maintain some degree of tonus. 24 Increased sympathetic nerve activity results in an increased HR and the vagal nerve's inhibitory effect on the sympathetic nerve is predominant at rest.…”

Section: Introductionmentioning

confidence: 99%

“…In veterinary medicine, HR and HR variability (HRV) are used to estimate autonomic nervous system function 23 . The HR is continually regulated by the action of the pacemaker while the sympathetic and vagal nerves maintain some degree of tonus 24 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study

Ogawa

Kawamura

Akabane

et al. 2022

Veterinary Record Open

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Background: Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV. Methods: Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3-2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL. Results:The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p < 0.05). The HRV for the whole 24 h and sleeping time were significantly higher after ivabradine compared with BL and after atenolol. Conclusions: In healthy cats, ivabradine and atenolol significantly reduced the HR regardless of excitement and rest; their effects were comparable. Ivabradine significantly increased HRV in comparison to BL whereas atenolol did not.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study

Ogawa

Kawamura

Akabane

et al. 2022

Veterinary Record Open

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Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes

García-González

Vallejo-Ruíz

Atonal-Flores

et al. 2022

Clinical and Experimental Hypertension

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A pilot study of patch Holter electrocardiograph recordings in healthy cats

Ogawa¹,

Kaba²,

Miyakawa³

et al. 2022

Open Vet J

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Background: A patch Holter electrocardiograph (P-Holter) is cordless, making it lightweight unlike the conventional Holter electrocardiograph (C-Holter). A P-Holter can also take continuous measurements. For up to 14 days without replacing the battery or SD card. Aim: The purpose of this study was to compare the performance of the P-Holter and the C-Holter in healthy cats. Additionally, we aimed to investigate whether multiday recordings with the P-Holter decrease sympathetic nerve activity or improve the accuracy of arrhythmia detection. Methods: Five healthy domestic short-haired cats were used for this study. Both a P-Holter and C-Holter were used on the first day, but only the P-Holter was used on days 2 to 6. The evaluated variables were the analyzable time of both Holter types, heart rate (HR), HR variability (HRV) and the number of arrhythmia occurrences. Results: For two out of the five cats, measurement of P-Holter was interrupted. Eventually, continuous recordings using the P-Holters were able to be collected from all individuals for 6 days. The 24 h analyzable time from the P-Holter and C-Holter was almost identical (p = 0.94). The 24 h mean HR did not differ across Holter types (p = 0.67). In addition, the timing of the occurrences of arrhythmias was almost identical to the P-Holter and C-Holter. Results of HRV suggested that sympathetic nerve activity was likely to decrease and vagal nerve activity was likely to increase after 4 to 5 days of measurement, compared to the second day of measurement (p < 0.05). When only the P-Holter was installed, the number of arrhythmia occurrences was similar on days 2 to 6. Conclusion: In this study, the P-Holter may be as useful as the C-Holter in cats with suspected intermittent arrhythmias, although these P-Holters were placed on cats without a clinical indication. However, cats may have individual differences in their adaptation to the device. P-Holter recordings taken for more than 4 to 5 days may allow the cat to acclimate to the device and reduce sympathetic nerve activity. The accuracy of arrhythmia detection across multiday P-Holter recordings requires further investigation using clinical cases.

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Evaluation of the Autonomic Nervous System in a Canine Model of Chronic Embolic Pulmonary Hypertension

Cited by 3 publications

References 22 publications

Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study

Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study

Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes

A pilot study of patch Holter electrocardiograph recordings in healthy cats

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