Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat

Haghdoost-Yazdi, Hashem; Sarookhani, Mohammad Reza; Faraj, Ayda; Fraidouni, Negin; Dargahi, Tahereh; Yaghoubidoust, Mohammad Hosein; Azhdari-Zarmehri, Hassan

doi:10.1016/j.pbb.2014.06.020

Cited by 10 publications

(9 citation statements)

References 53 publications

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“…Therefore, antiparkinsonian and neuroprotective effects of B com were probably mediated by reduction of oxidative stress. It was in agreement with several data showing that B vitamins had antioxidant effects (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: Discussionsupporting

confidence: 92%

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Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

Sarookhani¹,

Haghdoost-Yazdi²,

Piri³

et al. 2016

Biotech Health Sci

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Background: The current study evaluated the effects of a combination of flunarizine (flu) a calcium channel blocker, glibenclamide (Glib), a KATP channels blocker and B vitamins (B com) on the behavioral symptoms of 6-hydroxydopamine (6-OHDA)-induced model of Parkinson disease to examine the synergistic antiparkinsonian effects of the drugs and supplements. Also the level of malondialdehyde (MDA) was measured in blood and brain suspensions to find probable neuroprotective mechanism of these materials.

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Section: Discussionsupporting

confidence: 92%

“…tion of mitochondrial dysfunction and inhibition of oxidative stress (22). Previously, it was shown that B vitamins can reduce severity of behavioral symptoms in 6-hydroxydopamine (6-OHDA)-induced model of Parkinson disease (23,24).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

Sarookhani¹,

Haghdoost-Yazdi²,

Piri³

et al. 2016

Biotech Health Sci

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“…Behavioral assessment using the forelimb akinesia test showed that rats injected with 6-OHDA had a longer average step length for the limb contralateral to the lesioned hemisphere. Studies have shown that neurotoxininduced degeneration of dopamine neurons leads to motor deficit development that can be quantified using behavioral tests (Santiago et al, 2010;Haghdoost-Yazdi et al, 2014). The difficulty in movement initiation is a result of an increase in tonic inhibition of the neurons in the thalamocortical region of the brain (Warabi et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

2015

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“…Hence, this enzyme can relieve the inhibitory activities of SAH on S-adenosyl methionine (SAM)-dependent transmethylation reactions [17,18]. However, dysfunctional AHCY activity can result in serious pathological consequences, such as childhood death [19], Alzheimer' s disease [20], Parkinson' s disease [21], age-related diseases [22], neuroblastoma [23], and large-artery atherosclerotic stroke [24]. Despite these negative outcomes, few studies have investigated the relationship between AHCY DNA methylation of AHCY may increase the risk of ischemic stroke www.bjbms.org and the risk of ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation of AHCY may increase the risk of ischemic stroke

Жао

Chen

Zhou

et al. 2020

Bosn J of Basic Med Sci

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Genetic factors play an important role in the pathogenesis of ischemic stroke. Of these, epigenetic modifications provide a new direction for the study of ischemic stroke pathogenesis. This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke in 64 ischemic stroke patients and 138 patients with traumatic brain injury (control group). The methylation level of AHCY was analyzed using quantitative methylation-specific polymerase chain reaction. Statistically significant differences in AHCY methylation levels were observed between the case group [medians (interquartile range): 0.13% (0.09%, 0.27%)] and the control group [0.06% (0.00%, 0.17%), p < 0.0001], and these associations remained significant in both male (p = 0.003) and female (p = 0.0005) subjects. A subgroup analysis by age revealed a considerably higher percentage of methylated AHCY in the case group than the control group in all age groups (age < 60 years, p = 0.007; age ≥ 60 years, p < 0.0001). A receiver operating characteristic (ROC) curve analysis revealed a trend toward a role for AHCY methylation as an indicator of risk in all ischemic patients [area under the curve (AUC) = 0.70, p = 0.0001], male patients (AUC = 0.67, p = 0.004), and female patients (AUC = 0.75, p = 0.0002). Our study confirmed a significant association between the AHCY DNA methylation level and the risk of ischemic stroke, suggesting that this gene methylation pattern may be a potential diagnostic marker of ischemic stroke.

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Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat

Cited by 10 publications

References 53 publications

Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

Synergistic Antiparkinsonian Effect of Flunarizine, Glibenclamide and B Vitamins in a Rat 6-Hydroxydopamine Model; The Role of Malondialdehyde

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

DNA methylation of AHCY may increase the risk of ischemic stroke

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