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2014
DOI: 10.1016/j.pbb.2014.06.020
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Evaluation of the association between blood homocysteine concentration and the degree of behavioral symptoms in the 6-hydroxydopamine-induced Parkinsonism in rat

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Cited by 10 publications
(9 citation statements)
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“…Therefore, antiparkinsonian and neuroprotective effects of B com were probably mediated by reduction of oxidative stress. It was in agreement with several data showing that B vitamins had antioxidant effects (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Therefore, antiparkinsonian and neuroprotective effects of B com were probably mediated by reduction of oxidative stress. It was in agreement with several data showing that B vitamins had antioxidant effects (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”
Section: Discussionsupporting
confidence: 92%
“…tion of mitochondrial dysfunction and inhibition of oxidative stress (22). Previously, it was shown that B vitamins can reduce severity of behavioral symptoms in 6-hydroxydopamine (6-OHDA)-induced model of Parkinson disease (23,24).…”
Section: Introductionmentioning
confidence: 99%
“…Behavioral assessment using the forelimb akinesia test showed that rats injected with 6-OHDA had a longer average step length for the limb contralateral to the lesioned hemisphere. Studies have shown that neurotoxininduced degeneration of dopamine neurons leads to motor deficit development that can be quantified using behavioral tests (Santiago et al, 2010;Haghdoost-Yazdi et al, 2014). The difficulty in movement initiation is a result of an increase in tonic inhibition of the neurons in the thalamocortical region of the brain (Warabi et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Hence, this enzyme can relieve the inhibitory activities of SAH on S-adenosyl methionine (SAM)-dependent transmethylation reactions [17,18]. However, dysfunctional AHCY activity can result in serious pathological consequences, such as childhood death [19], Alzheimer' s disease [20], Parkinson' s disease [21], age-related diseases [22], neuroblastoma [23], and large-artery atherosclerotic stroke [24]. Despite these negative outcomes, few studies have investigated the relationship between AHCY DNA methylation of AHCY may increase the risk of ischemic stroke www.bjbms.org and the risk of ischemic stroke.…”
Section: Introductionmentioning
confidence: 99%