Evaluation of the association between diabetic retinopathy and the incidence of atrial fibrillation: A nationwide population-based study

Lee, So‐Ryoung; Choi, Eue Keun; Rhee, Tae‐Min; Lee, Hyunjung; Lim, Woo Hyun; Kang, Si Hyuck; Han, Kyungdo; Cha, Myung‐Jin; Cho, Youngjin; Oh, Il-Young; Oh, Seil

doi:10.1016/j.ijcard.2016.08.296

Cited by 65 publications

(45 citation statements)

References 35 publications

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“…Thus, insulin and sulfonylurea were used for the analysis. The subjects’ medical history, including the chronic obstructive pulmonary disease (COPD, J43–J44), all types of cancer (C00–C97), liver cirrhosis (K704, K746), end-stage renal disease (ESRD, N18, N19, Z49, Z905, Z94, and Z992 of ICD-10 code and R380, O7011–7020, O7017, and O7075 of the procedure code), and cardiovascular diseases (I21, I22, I63, and I64), was identified using the ICD-10 codes [11, 12]. BMI was calculated as weight in kilograms divided by the square of height in meters (kg/m²).…”

Section: Methodsmentioning

confidence: 99%

Association between BMI and risk of severe hypoglycaemia in type 2 diabetes

Yun

Park

Han

et al. 2019

Diabetes & Metabolism

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Section: Methodsmentioning

confidence: 99%

Association between BMI and risk of severe hypoglycaemia in type 2 diabetes

Yun

Park

Han

et al. 2019

Diabetes & Metabolism

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“…Baseline comorbidities were also evaluated during the screening period and defined using ICD-10-CM codes, as in our previous study 15–17 . Definitions of covariates are presented in the Supplemental Table.…”

Section: Methodsmentioning

confidence: 99%

Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study

Lim

Choi

Han

et al. 2017

Sci Rep

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Proteinuria is one of the well-known risk factors for cardiovascular disease. However the impact of proteinuria on the incidence of atrial fibrillation (AF) is unclear. In this study, we investigated the association between proteinuria detected using urine dipstick test and the risk of AF. A total of 18,201,275 individuals were analyzed, who had no prior AF and had received biennial health checkups provided by the National Health Insurance Service between 2005 and 2008 in Korea. Incidences of AF were ascertained through the end of 2015. During a mean follow-up of 9.6 years, a total of 324,764 (1.8%) developed AF (1.86 per 1,000 person-years). In Cox regression models, proteinuria was associated with an increased risk of AF: adjusted HR and 95% CI of AF occurrence were 1.13 (1.10–1.16), 1.34 (1.31–1.38), 1.53 (1.48–1.58), 1.82 (1.71–1.94), and 1.86 (1.61–2.16) in individuals with trace, 1+, 2+, 3+, and 4+ proteinuria, respectively, compared with those without proteinuria. The result was consistent even after additional adjustment for estimated glomerular filtration rate. In addition, the risk of AF further increased or decreased according to the follow-up dipstick test results. Thus, proteinuria measured with a dipstick test might be considered a potent risk factor for AF development.

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“…Besides, TAP1 (lying within the MHC II region) was also associated with pMN [77]. The association between pMN and DRB1*1501 was discovered in a Japanese cohort, together with DR2 and DQ1 [78, 79]. They reported a risk haplotype DRB1*1501-DQB1*0602 in pMN [80].…”

Section: Genetic Studies Of Pmnmentioning

confidence: 99%

The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China

2018

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Background: Primary membranous nephropathy (pMN) is the most common cause of nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the frequency of pMN in primary glomerular disease was witnessed in China. The genetic and environmental contributors to disease susceptibility have been investigated in these patients. Summary: We reviewed recent publications in genetic and environmental studies of pMN, focusing mainly on those undertaken in China. Following a genome-wide association study, the gene-gene interaction between the 2 most significant risk factors, PLA2R1 and DQA1, was validated in Chinese patients with MN. Fine mapping on human leukocyte antigen (HLA) locus found that DRB1*1501 and DRB1*0301 were risk alleles. Three amino acid residues on positions 13 and 71 of HLA-DRβ1 chain may confer the susceptibility to pMN by presenting T-cell epitopes on PLA2R. Another study found that DRB3*0202 was the most likely culprit allele for the signal at DRB1*0301. One environmental risk factor for pMN has been identified as the long-term exposure to high levels of PM_2.5 in Chinese patients with MN. Each 10 μg/m³ increase in PM_2.5 concentration was associated with 14% higher odds for pMN in the regions with PM_2.5 above 70 μg/m³. Key Message: A gene-environment interaction is suspected as an underlying mechanism for the increasing trend of pMN in China.

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Evaluation of the association between diabetic retinopathy and the incidence of atrial fibrillation: A nationwide population-based study

Cited by 65 publications

References 35 publications

Association between BMI and risk of severe hypoglycaemia in type 2 diabetes

Association between BMI and risk of severe hypoglycaemia in type 2 diabetes

Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study

The Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China

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