Evaluation of the antiviral activity of an aqueous extract from Phyllanthus orbicularis

Barrio, Gloria del; Parra, Francisco

doi:10.1016/s0378-8741(00)00228-2

Cited by 65 publications

(43 citation statements)

References 15 publications

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“…1). These results are consistent with studies on the antiviral activity of this and other plant extracts (Cheng et al 2004;del Barrio and Parra 2000;Felipe et al 2006). As this may have been due to the ability of some constituents present in the aqueous extract to directly inactivate viral particles, we carried out virucidal assays.…”

Section: Article In Presssupporting

confidence: 89%

“…A voucher specimen was delivered to the National Botanical Garden of Cuba (herbarium number: 7-220-HAJB) and authenticated by Dr. Rosalina Berazaín, a researcher from that institution. The aqueous extract used in this work was prepared and lyophilized as previously described (del Barrio and Parra 2000). Briefly, the plant stem and leaves were dried at 50 1C for three days, before grinding.…”

Section: Plant Extractmentioning

confidence: 99%

“…The Cuban endemic species Phyllanthus orbicularis H.B.K., widely used in Cuban folk medicine, has also been investigated and its anti-hepatitis B virus activity was confirmed (del Barrio et al 1995). In addition, we communicated the antiviral activity of this plant against HSV-1, HSV-2 and bovine herpesvirus-1 (BHV-1) (subfamily Alphaherpesvirinae) (del Barrio and Parra 2000;Fernandez-Romero et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis

et al. 2009

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The Herpesviridae includes at least eight viral species pathogenic for humans, responsible for a wide variety of clinical symptoms. The lack of an effective vaccine and the moderate to high toxicity of the available synthetic antiherpes compounds emphasises the need for new inhibitors. Several Phyllanthus genus (Euphorbiaceae) members have been widely used in traditional medicine and their biological properties have been intensely studied. In this study we investigated the in vitro antiviral activity of the Cuban-endemic plant Phyllanthus orbicularis H.B.K. against Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) reference strains and clinical isolates with different sensitivities to acyclovir. The inhibitory activity on Human cytomegalovirus (HCMV) replication was also investigated. The selectivity indexes (SI) found for Ph. orbicularis aqueous extract ranged from 8.7 to 37.6. Studies on the antiviral mechanisms involved revealed that the drug acted at early stages of herpesvirus replication, possibly by producing a virucidal effect, although further inhibition of intracellular replication events could not be ruled out.

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Section: Article In Presssupporting

confidence: 89%

Section: Plant Extractmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis

et al. 2009

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“…Published literature on natural and synthetic antiviral compounds reveals that the activity against HSV was often dependent on m.o.i. (Akanitapichat et al, 2000;del Barrio & Parra, 2000;Lowden & Bastow, 2003) and/or origin of host cell (Serkedjieva & Ivancheva, 1999;del Barrio & Parra, 2000). The current results indicated that inhibition of PPRV by BExt was much greater with lower (0.01) m.o.i.…”

Section: Resultsmentioning

confidence: 63%

Potential Effect ofAcacia arabica. onPeste des Petits Ruminants. Virus Replication

Balamurugan

Saravanan

Bhanuprakash

et al. 2008

Pharmaceutical Biology

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“…The plant species presenting strong antiviral activity for one or more viruses are Several reports showed antiviral activity against BoHV-1 of several plant species (Simoni et al 1996, Summerfield et al 1997, Barrio & Parra, 2000, Biltoveni et al 2005, Felipe et al 2006, Melo et al 2006) but few against the two avian viruses (IBDV and…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antiviral Activity of Brazilian Cerrado Plants Against Animal Viruses

Simoni¹,

Manha²,

Sciessere³

et al. 2007

VR&R

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Medicinal plants are abundant in the Brazilian flora including the Cerrado region.Extracts of sixteen plant species of the Brazilian Cerrado were investigated in vitro for antiviral activity against bovine herpesviruses type 1 (BoHV-1), infectious bursal disease virus (IBDV) and avian reovirus. Eight plants presented potent antiviral activity. Erythroxylum deciduum, Lacistema hasslerianum and Xylopia aromatica againstBoHV-1; Gochnatia polymorpha and Lithraea molleoides against avian reovirus; and Banisteriopsis variabilis, Byrsonima intermedia and Campomanesia xanthocarpa against both viruses. No extract was active against IBDV.

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Evaluation of the antiviral activity of an aqueous extract from Phyllanthus orbicularis

Cited by 65 publications

References 15 publications

In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis

In vitro anti-herpetic activity of an aqueous extract from the plant Phyllanthus orbicularis

Potential Effect ofAcacia arabica. onPeste des Petits Ruminants. Virus Replication

Evaluation of the Antiviral Activity of Brazilian Cerrado Plants Against Animal Viruses

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