Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models

Andrade, Sérgio Faloni de; Lemos, Marivane; Comunello, Eros; Noldin, Vânia Floriani; Filho, Valdir Cechinel; Niero, Rivaldo

doi:10.1016/j.jep.2007.06.002

Cited by 66 publications

(40 citation statements)

References 36 publications

(46 reference statements)

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“…Maytenus is known in particular for its anti-ulcerogenic properties, which appear to be related to its triterpenes (Andrade et al, 2007), which were also confirmed here for M. rigida, and suggest it may be used as a substitute for Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa Sandra S. Mendes et al other species of the genus. Aristolochia birostris was also found to contain triterpenoids, reflecting the findings of Wu et al (2004).…”

Section: Genotoxicity Test Of Maytenus Rigida and Aristolochia Birostsupporting

confidence: 78%

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Mendes¹,

Andrade²,

Xavier³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera -Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae -were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.

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Section: Genotoxicity Test Of Maytenus Rigida and Aristolochia Birostsupporting

confidence: 78%

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Mendes¹,

Andrade²,

Xavier³

et al. 2012

Rev. bras. farmacogn.

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“…It has also been demonstrated antimutagenic, antioxidant and antimicrobial properties of M. krukovii (Bruni et al, 2006) as well as inhibitory activity of the DNA polymerase -lyase of M. putterlickoides (Feng et al, 2004). It was also documented an analgesic property for M. aquifolium (Gonzáles et al, 2001) as well as antiulcerogenic activity of M. robusta (Andrade et al, 2007). M. senegalensis revealed antiplasmodial (Gessler et al, 1995;El Tahir et al, 1999), antibacterial (Matu & van Staden, 2003), antiviral activities (Otake et al, 1995) and antitumor property (Gessler et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the toxicity and antiulcerogenic activity of the ethanol extract of Maytenus obtusifolia Mart. leaves

Mota¹,

Pita²,

Estevam³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Avaliação da toxicidade e atividade antiulcerogênica do extrato etanólico das folhas de Maytenus obtusifolia Mart." Maytenus obtusifolia é utilizada na medicina popular para o tratamento de úlceras graves, infl amações gerais e câncer. Apesar da importância etnofarmacológica desta espécie, nenhum estudo foi realizado para avaliar a sua toxicidade e atividade antiulcerogênica. Neste estudo, nós avaliamos a toxicidade e propriedade antiulcera do extrato etanólico das folhas de Maytenus obtusifolia (MO-EtOH). O MO-EtOH (10-1000 g/mL) mostrou baixa toxicidade para as larvas de A. salina com CL 50 maior que 1000 g/mL. O MOEtOH (2000 mg/kg, p.o.) não alterou o peso corporal e peso dos órgãos dos camundongos, mas foi observado um aumento no consumo de água dos machos e uma diminuição do consumo alimentar das fêmeas. Durante o estudo não foram observadas mortes e nem alterações macroscópicas nos órgãos dos camundongos. 5, 125, 250 e 500 mg/kg) e lansoprazol (30 mg/kg) reduziram signifi cativamente o índice ulcerativo para 65,58 8,74, 43,00 9,53, 15,50 7,56, 54,75 8,88 ABSTRACT:Maytenus obtusifolia is used in folk medicine for the treatment of serious ulcers, general infl ammations and cancer. Despite of the ethnopharmacological importance of this species, no study was conducted to evaluate its toxicity and antiulcerogenic activity. In this study, we evaluated the toxicity and antiulcerogenic property of the ethanol extract of the leaves of Maytenus obtusifolia (MO-EtOH). The MO-EtOH (10-1000 g/mL) showed low toxicity for larvae of A. salina with LC 50 higher than 1000 g/mL. The MO-EtOH (2000 mg/kg, p.o.) did not change the body and organs weight of the mice, but it was observed an increase in the water consumption of males and a decrease in the food consumption of females. During the study no deaths and no macroscopic changes in the organs were observed in the mice. 125, 250 and 500 mg/kg) and lansoprazole (30 mg/kg) signifi cantly reduced the ulcerative index for 65.58 8.74, 43.00 9.53, 15.50 7.56, 54.75 8.88 and 36.13 9.55, respectively, in comparison with saline 82.13 12.48. In conclusion, the MO-EtOH showed low toxicity and antiulcerogenic activity, confi rming the popular use of M. obtusifolia.

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“…D i v e r s o s e s t u d o s e v i d e n c i a r a m a capacidade anti-ulcerogênica de algumas espécies vegetais (Andrade et al, 2007;Silva et al, 2010;Alimi et al, 2011). Na espécie Maytenus robusta (Celastraceae), o efeito antiulcerogênico foi atribuído, em parte, a presença de flavonóides em sua composição química (Andrade et al, 2007).…”

Section: Introductionunclassified

“…Na espécie Maytenus robusta (Celastraceae), o efeito antiulcerogênico foi atribuído, em parte, a presença de flavonóides em sua composição química (Andrade et al, 2007). As frações aquosa e butanólica da espécie Abarema cochliacarpos (Fabaceae) apresentaram atividade antiulcerogênica, assim esse efeito pode estar relacionado à presença de polifenóis, incluindo taninos (Silva et al, 2010).…”

Section: Introductionunclassified

Atividade gastroprotetora do extrato etanólico de Pavonia alnifolia A.St.-Hil.

Ewald

Loyolla

Pereira

et al. 2015

Rev. bras. plantas med.

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RESUMO:No Brasil, a família Malvaceae está representada por aproximadamente 200 espécies e algumas foram descritas como gastroproteroras. Pavonia alnifolia A.St.-Hil. (Malvaceae) foi selecionada após uma abordagem quimiossistemática, considerando-se sua potencial capacidade em prevenir lesões gástricas. Assim, a atividade gastroprotetora do extrato etanólico de caules de P. alnifolia foi avaliada utilizando o modelo de indução aguda da lesão gástrica por etanol acidificado em camundongos. Além disso, foram quantificados o teor de flavonóides, pelo método de cloreto de alumínio, e de polifenóis, pelo método Folin-Ciocalteu, uma vez que a relação desses componentes com a proteção gástrica foi evidenciada. Os ensaios apontaram redução acentuada das lesões gástricas em camundongos tratados com o extrato da planta em todas as doses ensaiadas (10, 100 e 300 mg/kg). Esse efeito pode estar relacionado com a presença de polifenóis, cujo teor encontrado foi 74,3 ± 7,5 µg equivalente de pirogalol/mg do material vegetal examinado e 82,7 ± 7,1 µg equivalente de pirogalol /mg da amostra no extrato preparado por percolação e teor de flavonoides totais, que por sua vez apresentou um resultado de 17,1 ± 1,4 µg/mg de extrato. O extrato apresentou proteção da mucosa gástrica e este efeito pode estar relacionado à presença dos polifenóis e flavonóides encontrados. Palavras-chave:Pavonia, Malvaceae, gastroproteção, flavonóides, polifenóis.ABSTRACT: Gastro protective activity of the Pavonia alnifolia A.St.-Hil. extract. In Brazil, the Malvaceae family is represented by at about 200 species. Some of those species are known as gastro protective ones. The Pavonia alnifolia A.St.-Hil (Malvaceae) was selected after a chemosystematic approach. The gastro preventive activity of the ethanol extract of stems Pavonia alnifolia was evaluated through the use of the Ethanol:chlroridric acid model on mice. The quantification of the total flavonoids (aluminum chloride method) and total polyphenols (Folin-Ciocalteu method) was also performed since the relation of those components with gastric protection has been previously highlighted. The tests showed a significant reduction of the ulcer formation in the mice treated with the plant extract (10, 100 and 300 mg/kg). This effect may be related to the presence of polyphenols whose content was found to be 74.3 ± 7.5 µg/mg of vegetal material and 82.7 ± 7.1 µg/mg of crude extract and flavonoids, which in turn showed a content of 17.1 ± 1.4 µg/mg dry extract.

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Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models

Cited by 66 publications

References 36 publications

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Evaluation of the toxicity and antiulcerogenic activity of the ethanol extract of Maytenus obtusifolia Mart. leaves

Atividade gastroprotetora do extrato etanólico de Pavonia alnifolia A.St.-Hil.

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