Evaluation of the antitumor activity of a series of the pincer-type metallocomplexes produced from isonicotinohydrazide derivative

Demir, Burcu Saygıdeğer; Mahmoudi, Ghodrat; Sezan, Aycan; Derinöz, Ezgi; Nas, Eylem; Kont, Yasemin Saygideğer; Зубков, Федор И.; Zangrando, Ennio; Safin, Damir A.

doi:10.1016/j.jinorgbio.2021.111525

Cited by 7 publications

(2 citation statements)

References 81 publications

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“…Hydrazone molecules display a number of features, such as their degree of flexibility, a conjugatedsystem and an NH unit that readily participates in hydrogen bonding and may be easily deprotonated. In addition, hydrazone molecules behave as bidentate ligands through their carbonyl oxygen and azomethine nitrogen atoms, and are widely used in coordination chemistry for their ability to form complexes with metal ions in variable oxidation states (Abou-Melha, 2021;Abser et al, 2013;Saygıdeg ˘er Demir et al, 2021;Gond et al, 2022;Vela ´squez et al, 2020). In this respect, the formation of metal complexes plays an important role in enhancing the biological activity of hydrazones .…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of bis[4-(allyloxy)-N′-(but-2-en-1-ylidene)benzohydrazidato]nickel(II)

Khan¹,

Howlader²,

Sheikh³

et al. 2023

Acta Cryst E

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In the title complex, [Ni(C14H15N2O2)2], the nickel(II) atom exhibits a square-planar coordination geometry, being coordinated by two negatively charged N,O chelating ligands in a trans configuration, with the metal located on a crystallographic center of symmetry. The X-ray structural characterization showed the complex to be disordered over two orientations with refined occupancies of 0.898 (2) and 0.102 (2). The whole molecule is close to planar, the five- and six-membered rings subtending a dihedral angle of 7.5 (2)°. The crystal packing is supported by C—H...π and C—H...O interactions that form a di-periodic layered network.

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of bis[4-(allyloxy)-N′-(but-2-en-1-ylidene)benzohydrazidato]nickel(II)

Khan¹,

Howlader²,

Sheikh³

et al. 2023

Acta Cryst E

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“…Isoniazid (INH) is a synthetic antibacterial agent mainly used to treat tuberculosis, [23] which has good biocompatibility and pharmacokinetic characteristics and can be rapidly absorbed by the body through oral, intravenous, and intramuscular routes of administration [24,25] . INH and its derivatives are widely used in biology, [24] including anti‐mycobacteria, [26] anti‐bacteria, [27,28] anti‐virus, [28] anti‐fungus, [29] anti‐tumor [30–33] . Recently, the combination of INH with other active moieties is frequently applied for a variety of pharmacological effects [24] .…”

Section: Introductionmentioning

confidence: 99%

Gallium(III) Amide Corroles: DNA Interaction and Photodynamic Activity in Cancer Cells

Yang

Cen

et al. 2023

ChemPlusChem

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A series of gallium(III) amide corroles including meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Pyridinamide‐phenyl)corrole gallium (III) (1‐Ga), meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Furamide‐phenyl)corrole gallium(III) (2‐Ga) and meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Thiophenamide‐phenyl)corrole gallium(III) (3‐Ga) were synthesized. The interaction of these complexes with DNA and their photodynamic antitumor activities have been studied. UV spectra titration showed that these gallium(III) corroles interact with calf thymus DNA (CT‐DNA) through an external binding mode. All three gallium(III) corroles can effectively generate singlet oxygen under illumination and have good photostability. Among the three gallium(III) corroles, 2‐Ga exhibited excellent photodynamic antitumor activity against the tested tumor cell lines under light irradiation (625±2 nm, 0.3 mW/cm2, 1.08 J/cm2). The best phototoxicity was observed by 2‐Ga against HepG2 cells (IC50=6.3±0.9), which is even better than temoporfin (IC50=8.4±1.8). It could block HepG2 cells in the sub‐G0 phase and effectively induce apoptosis of HepG2 cells under 625 nm light irradiation.

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A readily available structural analogue of integrastatins A and B: Insight into the crystal structure, Hirshfeld surface analysis and computational study

et al. 2022

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Evaluation of the antitumor activity of a series of the pincer-type metallocomplexes produced from isonicotinohydrazide derivative

Cited by 7 publications

References 81 publications

Crystal structure of bis[4-(allyloxy)-N′-(but-2-en-1-ylidene)benzohydrazidato]nickel(II)

Crystal structure of bis[4-(allyloxy)-N′-(but-2-en-1-ylidene)benzohydrazidato]nickel(II)

Gallium(III) Amide Corroles: DNA Interaction and Photodynamic Activity in Cancer Cells

A readily available structural analogue of integrastatins A and B: Insight into the crystal structure, Hirshfeld surface analysis and computational study

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