Evaluation of the Antioxidative and Hypo-cholesterolemic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Ameliorating Cardiovascular Disease

Abstract

Oxidative stress (OS) and hypercholesterolemia have been linked with a heightened risk of cardiovascular disease (CVD). Because of the numerous drawbacks of synthetic antioxidants and cholesterol-lowering drugs, natural antioxidative and hypocholesterolemic agents are of immense importance. This study was designed to determine both the OS-attenuating and cholesterol-lowering capacities of the hot water extract (HWE) and of five solvent-solventpartitioned fractions of Ganoderma lucidum. In vitro antioxidative performance of G. lucidum HWE and fractions was measured through DPPH free radical scavenging, Folin-Ciocalteu assay, lipid peroxidation inhibition, and human low-density lipoprotein (LDL) oxidation inhibition. In vivo antioxidative performance of G. lucidum was assessed by measuring the plasma and liver antioxidative enzymatic activities (catalase, glutathione peroxidase, and superoxide dismutase) in G. lucidum HWE-fed rats. In the CVD tests, the HWE at 200 mg/kg b.w. lowered plasma levels of total cholesterol, triacylglycerol, and LDL cholesterol and increased high-density lipoprotein cholesterol. The current findings indicate the therapeutic potentiality of G. lucidum as an OS-attenuating and hypocholesterolemic agent en route to withstanding CVD complications.

Dietary Supplementation with Flammulina velutipes Stem Waste on Growth Performance, Fecal Short Chain Fatty Acids and Serum Profile in Weaned Piglets

“…Previous studies have showed that a reduction in concentrations of LDL cholesterol could markedly reduce the risk of stroke and coronary heart disease incidence and mortality [35]. Many previous studies have also shown that mushroom has excellent effects on lowering the LDL content [36,37]. Therefore, dietary FVS could benefit the health of piglets through lowering the LDL content in serum.…”

Suillus collinitus (Fr.) Kuntze ekstraktlarının insan lenfositlerinin genotoksisitesi ve proliferasyonu üzerindeki etkileri

“…Many edible mushroom species analysed for their medicinal properties have been found to contain many active ingredients. These compounds have been shown to strengthen the immune system, have anti-carcinogenic and cholesterol-lowering properties and act as protective agents against hepatitis (De Silva et al, 2012;Rahman et al, 2018).…”

Ganoderma Lucidum Modulates Neuronal Structure and Function Regulatory Protein Expression and Protein-protein Interaction in Alzheimer’s Disease Model Animals

“…The State Pharmacopoeia of the People's Republic of China (2000) has incorporated G. lucidum as the potent replenisher of Qi (life force), salient mind soothening and cough relieving as well as anti-asthmatic agent [2]. Modern medicinal sector also acknowledge its inclusion as a therapeutic agent against numerous physiological disorders including, but not limited to, antioxidant, anti-in ammatory, antitumor, anticancer, antimicrobial, immunomodulatory and hepatoprotective agent [3][4][5][6][7]. Content of more than 400 gano-components had accredited Ganoderma as the "fungal biofactory", "panacea" and the "elixir of life" [3][4][5][6][7].…”

“…Modern medicinal sector also acknowledge its inclusion as a therapeutic agent against numerous physiological disorders including, but not limited to, antioxidant, anti-in ammatory, antitumor, anticancer, antimicrobial, immunomodulatory and hepatoprotective agent [3][4][5][6][7]. Content of more than 400 gano-components had accredited Ganoderma as the "fungal biofactory", "panacea" and the "elixir of life" [3][4][5][6][7]. Gano-components conferring medicinal values range from polysaccharides to triterpenes, sterols, proteins, peptides, fatty acids and vitamins [3][4][5][6][7].…”

“…Content of more than 400 gano-components had accredited Ganoderma as the "fungal biofactory", "panacea" and the "elixir of life" [3][4][5][6][7]. Gano-components conferring medicinal values range from polysaccharides to triterpenes, sterols, proteins, peptides, fatty acids and vitamins [3][4][5][6][7]. Recently, utilization of G. lucidum in ameliorating neurodegenerative diseases like Alzheimer's disease (AD), have received epoch-making attention [8].…”