Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm

Alisi, Ikechukwu Ogadimma; Uzairu, Adamu; Abechi, Stephen Eyije; Idris, S. O.

doi:10.1016/j.jare.2018.03.003

“…However, these alterations were ameliorated by treatment with curcumin irrespective of the dose given. These findings were in agreement with the previous studies that have reported the antioxidant properties of curcumin [41][42][43].…”

Section: Discussionsupporting

confidence: 94%

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

Abubakar¹,

Mailafiya²,

Danmaigoro³

et al. 2019

Preprint

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Lead (Pb) is a toxic environmental heavy metal that induces serious clinical defect on all organs with the nervous system being the primary target. Curcumin is the main active constituent of turmeric rhizome (Curcuma longa) with strong antioxidant and anti-inflammatory properties. This study is aimed at evaluating the therapeutic potentials of curcumin on Pb-induced neurotoxicity. Thirty six male Sprague Dawley rats were randomly assigned into five (5) groups with 12 rats in the control (normal saline) and 6 rats for the lead treated group (LTG) (50 mg/kg lead acetate for 4 weeks), recovery group (RC) (50 mg/kg lead acetate for 4 weeks), treatment group 1 (Cur100) (50 mg/kg lead acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks) and treatment group 2 (Cur200) (50 mg/kg lead acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks) groups each. All experimental groups received the oral treatments through orogastric-tube on alternate days. Motor function was assessed using horizontal bar method while Pb concentration in the cerebellum of the rats were evaluated using ICP-MS techniques. Pb-administered rats showed significant decrease in motor scores, SOD activity with increase MDA levels and Pb concentration in their cerebellum with marked alterations in the histological architecture of the cerebellar cortex layers. However, treatment with curcumin improved the motor score, reduced Pb concentration in the cerebellum and ameliorates the markers of oxidative stress as well as restored the histological architecture of the cerebellum. The results this in study suggested that curcumin attenuates Pb-induced neurotoxicity via inhibition of oxidative stress and chelating activity.

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“…However, Amalraj et al [20,21,25] concluded that CL caused a decrease in lipid peroxidation and an increase in antioxidant defense system activity in the CCl 4 -treated rats. Our findings are in accordance with previous reports of other related studies [17,18,23] that have suggested the protective role of CL powder, possibly due to the antioxidative effect of polyphenols and flavonoids present in the roots, that act as strong superoxide radicals and singlet oxygen quenchers. Also, we agree with Shakeri et al [26] who concluded treatment with CL rhizome extract caused an elevation of GSH levels, which protects the membranes against oxidative damage through regulation of the redox status of protein in the membrane.…”

Section: Discussionsupporting

confidence: 94%

“…e inhibition of lipid peroxides as well as an increase in SOD and G-Px activity, among the treatment groups (Txs) immediately after oral administration of CL (which peaked after three days) in the current investigation, could presumably be explained as protective effects of CL against oxidative damage. Furthermore, a decrease observed in MDA levels in the Tx groups following CL supplementation is suggestive that CL has appreciable free-radical scavenger properties and possesses the ability to suppress lipid peroxidation as similarly reported in previous studies [17]. Regulation of lipid peroxidation, radical scavenging, and antioxidant status may be one of the important mechanisms by which CL exerts its toxic inhibitory effect.…”

Section: Discussionsupporting

confidence: 84%

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Hasan

¹

2020

Evidence-Based Complementary and Alternative Medicine

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The rhizomes of Curcuma longa L. (CL) have been widely used in herbal medicines worldwide. It has been shown to possess prophylactic effects against oxidative stress. However, there is a paucity of information regarding the protective role of CL against oxidative stress in the absence of toxic agents. The aim of the study was to elucidate the antioxidative stress pharmacodynamics of CL. Eighteen 12-week-old Sprague-Dawley rats weighing about 300 ± 25 gm were divided equally into six groups. Four of the groups were supplemented with CL at 100 mg/kg b.w./day orally (P.O.) and labeled as 1st, 3rd, 5th, and 6th day groups. The PCx (positive control) group was given distilled water orally, and the NCx (negative control) group rats were provided with food and water ad libitum. Blood samples were collected, and rats were sacrificed on days 1, 3, 5, and 6 (2 h) posttreatment. The blood was used for oxidative stress enzyme analysis (SOD, GSH-Px, and MDA) and liver (ALT) and kidney (creatinine) function assay, and the liver was dissected for histology. The results revealed that CL exhibited an antioxidative stress effect in the liver and kidneys as indicated by the low levels of ALT and creatinine. In response to antioxidant enzymes, especially that of the 3rd-day treatment group, an increase in SOD and GSH-Px indirectly caused an alleviation of oxidative stress, leading to a much lower level of MDA. It was concluded that treatment with CL at 100 mg/kg b.w./per day for three consecutive days demonstrated the highest efficacy in abating oxidative stress in rats.

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“…However, these alterations were ameliorated by treatment with curcumin irrespective of the dose given. These findings were in agreement with the previous studies that have reported the antioxidant properties of curcumin [47][48][49].…”

Section: Discussionsupporting

confidence: 94%

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

Abubakar¹,

Mm²,

Danmaigoro³

et al. 2019

Preprint

View full text Add to dashboard Cite

Lead (Pb) is a toxic environmental heavy metal that induces serious clinical defect on all organs with the nervous system being the primary target. Curcumin is the main active constituent of turmeric rhizome (Curcuma longa) with strong antioxidant and anti-inflammatory properties. This study is aimed at evaluating the therapeutic potentials of curcumin on Pb-induced neurotoxicity. Thirty six male Sprague Dawley rats were randomly assigned into five (5) groups with 12 rats in the control (normal saline) and 6 rats for the lead treated group (LTG) (50 mg/kg lead acetate for 4 weeks), recovery group (RC) (50 mg/kg lead acetate for 4 weeks), treatment group 1 (Cur100) (50 mg/kg lead acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks) and treatment group 2 (Cur200) (50 mg/kg lead acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks) groups each. All experimental groups received the oral treatments through orogastric-tube on alternate days. Motor function was assessed using horizontal bar method while Pb concentration in the cerebellum of the rats were evaluated using ICP-MS techniques. Pb-administered rats showed significant decrease in motor scores, SOD activity with increase MDA levels and Pb concentration in their cerebellum with marked alterations in the histological architecture of the cerebellar cortex layers. However, treatment with curcumin improved the motor score, reduced Pb concentration in the cerebellum and ameliorates the markers of oxidative stress as well as restored the histological architecture of the cerebellum. The results this in study suggested that curcumin attenuates Pb-induced neurotoxicity via inhibition of oxidative stress and chelating activity.

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Evaluation of the antioxidant properties of curcumin derivatives by genetic function algorithm

Abstract: Graphical abstract

Cited by 55 publications

References 34 publications

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Inhibition of Oxidative Stress and Chelating Activity

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