Evaluation of the Antioxidant Potential and Antioxidant Enzymes of Some Yemeni Grape Cultivars

Almulaiky, Yaaser Q.; Al-Shawafi, Waleed M.; Al-Talhi, Hasan A.; Zeyadi, Mustafa; Anwar, Firoz; Al‐Abbasi, Fahad A.; Khan, Ruqaiyah; Kumar, Vikas

doi:10.5530/fra.2017.1.11

Cited by 4 publications

(2 citation statements)

References 26 publications

(32 reference statements)

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“…Phenolic acid contains the major phenol containing groups which are served as a primary source of antioxidant or free radical scavenger, while polyphenols act as an antioxidant terminator by scavenging free radicals to form stable one. [ 28 29 ] In current findings, it was confirmed that phenol and flavonoids are present in G. dulcis rind extract, which are responsible for scavenging free radicals in various antioxidant models.…”

Section: Discussionsupporting

confidence: 74%

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Gogoi¹,

Gogoi²,

Neog³

et al. 2017

Phcog Res

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Background:Garcinia spp. belongs to the family Clusiaceae has been traditionally used for the treatment of many ailments including the liver damage. Garcinia dulcis found in North Eastern region of Assam; India can be a potential candidature to combat different ailments. Objective: The present work has been designed in such a way to appraisal the antioxidant and hepatoprotective activity of fruit rind extract of this plant.Materials and Methods:The antioxidant activity was investigated through the various in vitro models, namely, 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, nitrite oxide. Phytochemical investigation for total phenolic and flavonoids contents were carried out by standard protocol. For the evaluation of hepatoprotective activity, albino Wistar rats were divided into five groups, five animals per group and activity was determined by measuring the contents of liver function marker enzymes such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), and biochemical parameter, that is, Bilirubin and total protein. Histopathology observation of liver sections was conducted.Results:Phytochemical investigation revealed the presence of both phenolic and flavonoid groups in the extract in a significant amount. Antioxidant activity of the plant extract was observed in all models and percentage of inhibition was dose-dependent. Intoxicated with carbon tetrachloride, elevated the liver function enzymes, bilirubin, and suppressed the production of total protein. Pretreatment with the extract decreased the SGOT, SGPT, ALP, and bilirubin level significantly and increased the production level of total protein in a dose-dependent manner. The histopathological observation supported the hepatoprotective potentiality of the extract.Conclusion:The results indicate that fruit rind part of G. dulcis is nontoxic and the plant can utilize as an antioxidant source. The plant has a protective agent for liver damages and other diseases caused by free radicals.SUMMARY In vitro antioxidant and in vivo hepatoprotective activity was evaluatedMethanolic extract was subjected to quantify the both phenolic and flavonoid contents. The extract showed the significant amount of both phenolic and flavonoids contents. The extract showed the free radical scavenging activity in 2,2-diphenyl-1-picrylhydrazine, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid and nitrite oxide modelsThe extract was administrated against the carbon tetrachloride intoxicated animal models to evaluate the hepatoprotective activity by determining the level of liver marker enzymes such as serum glutamate pyruvate transaminase, SGOT, alkaline phosphatase and biochemical parameter such as protein and bilirubin. Pretreatment with the extract reversed the elevated level of the enzymes and increased the protein level in a dose-dependent mannerThe histopathological observations of the liver sections supported the hepatoprotective activity of the ex...

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Section: Discussionsupporting

confidence: 74%

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Gogoi¹,

Gogoi²,

Neog³

et al. 2017

Phcog Res

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show abstract

“…4 Flavonoid such as catechin and epicatechin are known to have antioxidant effects, antimicrobial and bactericidal activity. 18 Decreased plasma urea and creatinine levels due to presence flavonoids and tannins contained in WPIL might be an important role as antioxidant functions. 19 The previous study has found that WPIL contained epicatechin.…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effect of Pterocarpus indicus Willd. Leaves: Observation From Plasma Urea and Creatinine Levels Against Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats

Saputri¹,

Anjani

Mun’im³

2017

JYP

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Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG2 through nuclear factor-κB pathway

et al. 2017

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A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN) (200 mg/kg) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg) were used for induction of renal cell carcinoma (RCC) in the rats. The rats were further divided into different groups and were treated with HEG doses for 22 weeks. Anti-cancer effect in RCC by HEG was dose dependent to restrict the macroscopical changes as compared to DEN + Fe-NTA-control animals. Significant alteration in biochemical parameters and dose-dependent alleviation in Phase I and Phase II antioxidant enzymes were responsible for its chemo-protective nature. HEG in dose-dependent manner was significant to alter the elevated levels of pro-inflammatory cytokines and inflammatory mediators during RCC. The histopathological changes were observed in the HEG pre-treated group, which was proof for its safety concern as far as its toxicity is concerned. The isolated compound HEG can impart momentous chemo-protection against experimental RCC by suppressing the cyclooxygenase (COX-2) and prostaglandin E2 (PGE) expression via nuclear factor-kappa B (NF-κB) pathway.

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Evaluation of the Antioxidant Potential and Antioxidant Enzymes of Some Yemeni Grape Cultivars

Cited by 4 publications

References 26 publications

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Evaluation of antioxidant and hepatoprotective activity of fruit rind extract of Garcinia dulcis (Roxburgh) Kurz

Nephroprotective Effect of Pterocarpus indicus Willd. Leaves: Observation From Plasma Urea and Creatinine Levels Against Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats

Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG2 through nuclear factor-κB pathway

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