Evaluation of the antioxidant effects of melatonin on the larynx mucosa of rats exposed to environmental tobacco smoke

Donmez, Zeynep; Yiğit, Özgür; Bilici, Suat; Dursun, Nevra; Gül, Mehmet; Daştan, Sevgi Durna; Uzun, Hafize

doi:10.1111/coa.12501

Cited by 6 publications

(4 citation statements)

References 35 publications

(61 reference statements)

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“…Indoleamine also has a protective effect on other organs such as the thyroid, larynx, kidneys and pancreas (36)(37)(38)(39)(40)(41). Melatonin reduces hyperthyroidism induced by oxidative stress in hamsters and decreases nerve cell death in the region of the hippocampus of the brain.…”

Section: Animal Modelmentioning

confidence: 99%

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Melatonin as a powerful antioxidant

Chrustek

Olszewska−Słonina

2020

Acta Pharmaceutica

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Melatonin is a hormone that has many body functions and, for several decades, its antioxidant potential has been increasingly talked about. There is a relationship between failure in melatonin production in the pineal gland, an insufficient supply of this hormone to the body, and the occurrence of free radical etiology diseases such as neurodegenerative diseases, cardiovascular diseases, diabetes, cancer and others. Despite the development of molecular biology, numerous in vitro and in vivo studies, the exact mechanism of melatonin antioxidant activity is still unknown. Nowadays, the use of melatonin supplementation is more and more common, not only to prevent insomnia, but also to slow down the aging process and provide protection against diseases. The aim of this study is to get acquainted with current reports on melatonin, antioxidative mechanisms and their importance in diseases of free radical etiology.

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Section: Animal Modelmentioning

confidence: 99%

“…Smoking causes pathological changes in the mucous membrane of the larynx and the development of tumors. Studies in rats have shown that melatonin may, to a certain extent, suppress adverse effects, which may be important for smokers (41).…”

Section: Animal Modelmentioning

confidence: 99%

Melatonin as a powerful antioxidant

Chrustek

Olszewska−Słonina

2020

Acta Pharmaceutica

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“…MT is likely an effective therapy for minimizing certain adverse consequences of smoking and can be used as a scavenger to counteract the oxidative damage that smoking causes. Moreover, by inhibiting the activation of oxidants and, in turn, stimulating pathways in which antioxidant enzymes are involved, intraperitoneal MT injection decreased oxidative stress damage and mitigated the adverse effects of smoking [28].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Salivary Melatonin Levels and Many Periodontal Parameters in Cigarette Smokers with Periodontitis

Ali

Mohammed

2023

amj

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Background: Adults who have periodontitis are more likely to lose teeth, which affects their quality of life and causes masticatory dysfunction. Most people agree that smoking tobacco makes them more likely to get oral mucosal and periodontal diseases and makes the oral microbiome less balanced. Melatonin is a naturally occurring hormone that is released in a variety of organs. Objectives: To examine the relationship between smoking and salivary melatonin levels in periodontitis patients vs healthy people, and to establish a relationship between melatonin levels and periodontal parameters.

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“…We have evaluated and ranked the protective effects of 5 popular, highly commercialized and readily available over the counter (OTC) antioxidants (Coenzyme Q10, Melatonin, Glutathione, Lipoic acid and Resveratrol) to prevent BBB endothelial damage caused by exposure to soluble CSE. Although protective effects of these antioxidants against CS induced injury in different medical conditions have been reported in a few occasions, melatonin, for example has been proven to be a useful against CS induced kidney damage (Ozan, Sonmez, Ozan, Colakoglu, Yilmaz, and Kuloglu, 2007), vasculopathy (Rodella, Filippini, Bonomini, Bresciani, Reiter, and Rezzani, 2010), inflammation of the larynx (Donmez, Yigit, Bilici, Dursun, Gul, Dastan, and Uzun, 2015) and arterial occlusion (Yang, Li, Wang, Liu, Ye, Ni, Zeng, Miao, Wang, and Liu, 2014) while resveratrol and lipoic acid have been shown to have beneficial roles against CS induced pulmonary inflammation (Liu, Ren, Chen, Huang, Li, Zhang, and Wang, 2014) and oxidative damage respectively (Jia, Liu, Sun, Miller, Ames, Cotman, and Liu, 2007). For the first time, our lab is reporting the protective effects of all five of these popular antioxidants against CS induced damage to BBB.…”

Section: Introductionmentioning

confidence: 99%

Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial?

2015

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Blood Brain Barrier (BBB) exposed to realistic concentrations (comparable to a chronic heavy smoker) of Cigarette Smoke Extract (CSE) triggers a strong endothelial inflammatory which can lead to the onset of neurological disorders. The involvement of Reactive Oxygen Species (ROS) in this inflammatory cascade is evident from the up-regulation of nuclear factor erythroid 2 related factor 2 (Nrf-2), a transcription factor involved in anti-oxidant response signaling in CSE exposed endothelial cells. We have shown that pre-treatment with α-tocopherol and/or ascorbic acid is highly protective for the BBB, thus suggesting that, prophylactic administration of antioxidants can reduce CSE and/or inflammatory-dependent BBB damage. We have assessed and ranked the protective effects of 5 popular OTC antioxidants (Coenzyme Q10, Melatonin, Glutathione, Lipoic acid and Resveratrol) against CSE-induced BBB endothelial damage using hCMEC/D3 cells. The analysis of pro-inflammatory cytokines release by ELISA revealed that, resveratrol, lipoic acid melatonin and Co-Q10 inhibited the BBB endothelial release of pro-inflammatory cytokines IL-6 & IL-8, reduced (not Co-Q10) CSE-induced up-regulation of Platelet Endothelial Cell Adhesion Molecule -1 (PECAM-1), Vascular Endothelial Cell Adhesion Molecule-1 (VCAM-1) & E-selectin and inhibited monocytes-endothelial cell adhesion. The anti-inflammatory effects correlated with the anti-oxidative protection endowed by these compounds as evidenced by upregulation of NADPH: Quinone Oxidoreductase 1 (NQO1) and reduced cellular oxidative stress. CSE-induced release of Vascular Endothelial Growth Factor (VEGF) was inhibited by all tested compounds although the effect was not strictly dose-dependent. Further in vivo studies are required to validate our results and expand our current study to include combinatorial treatments.

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Evaluation of the antioxidant effects of melatonin on the larynx mucosa of rats exposed to environmental tobacco smoke

Cited by 6 publications

References 35 publications

Melatonin as a powerful antioxidant

Melatonin as a powerful antioxidant

Correlation of Salivary Melatonin Levels and Many Periodontal Parameters in Cigarette Smokers with Periodontitis

Protecting the BBB endothelium against cigarette smoke-induced oxidative stress using popular antioxidants: Are they really beneficial?

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