Evaluation of The Antioxidant, Antidiabetic and Immunomodulatory Activity of Cydonia oblonga Fruit Extract

Sakhri, Fatma Zahra; Zerizer, Sakina; Bensouici, Chawki

doi:10.12982/cmujns.2021.052

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…An overall immunostimulatory effect was induced in a dose-dependent manner by tested extracts of AMH and BBH. Our results are in line with other studies which reported that different plant extracts rich in polyphenols and flavonoids exerted a considerable immunostimulatory effect [47][48][49][50][51]. Secondary metabolites such as flavonoids, polysaccharides, lactones, alkaloids, diterpenoids, and glycosides are present in several plants, and have been reported to be responsible for the plants immunomodulating properties.…”

Section: Discussionsupporting

confidence: 92%

In vitro and in vivo bioactivities of Ambrosia maritima and Bituminaria bituminosa organic extracts from Algeria

Ramli

Zerizer

Gali³

et al. 2022

J Infect Dev Ctries

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Introduction: Two medicinal plants, Ambrosia maritima and Bituminaria bituminosa, growing in Algeria were investigated for their flavonoids content and their biological activities. Methodology: Different organic extracts were prepared from the aerial parts of each plant using maceration method followed by liquid/liquid type extractions. The anti-antioxidant activity was tested using the β-carotene bleaching method. The anti-inflammatory activity was tested by performing the protein anti-denaturation assay. Acute toxicity and immunostimulatory effect were tested in mice, while the antimicrobial activity was tested according to the minimal inhibition concentration technique. Results: In term of flavonoids content, ethyl acetate extract of B. bituminosa was the highest (193.39 ± 24.1 µg QE/mg). Ethyl acetate extract of A. maritima showed antioxidant activity with IC50 value of 11.72 ± 0.79 µg/mL. The hydroethanolic extract of A. maritima showed the best anti-denaturation effect in a dose-dependent manner with the IC50 value of 131.07 ± 0.027 µg/mL. The studied plants showed no toxicity or mortality in vivo. Both plants showed a significant immunostimulatory effect; while the Butanolic extract of B. bituminosa demonstrated the best antimicrobial activity against Staphylococcus aureus and Candida albicans strains. Conclusions: We recommend A. maritima and B. bituminosa as potent sources of antioxidants and as antimicrobial agents for further assays to better elucidate their actions on the immune system.

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Section: Discussionsupporting

confidence: 92%

In vitro and in vivo bioactivities of Ambrosia maritima and Bituminaria bituminosa organic extracts from Algeria

Ramli

Zerizer

Gali³

et al. 2022

J Infect Dev Ctries

Self Cite

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“…Our results are consistent with prior researches showing that plants high in flavonoids and polyphenols have significant immune-stimulating effects. 47–51 …”

Section: Discussionmentioning

confidence: 99%

In-vivo Immunomodulatory Activities of Essential Oils of Artemisia abyssinica and Lepidium sativum in Mice

Ayenew,

Ayalew,

Wondmkun

et al. 2024

ITT

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Background Ethiopians use Artemisia abyssinica and Lepidium sativum as immunity enhancers. However, there is no scientific validation conducted so far regarding this claim. The aim of this study was to investigate the in-vivo immunomodulatory activities of essential oils of A. abyssinica and L. sativum in mice. Methods The extraction was carried out using the earlier techniques. By hydro distilling fresh seeds and aerial portions of A. abyssinica and L. sativum , respectively, essential oils were obtained. Essential oils of both plants were tested at 100, 200 and 400 mg/kg. The rate of carbon clearance, humoral antibody titer, delayed type hypersensitivity response, spleen and thymus indices were evaluated in mice according to scientific protocols. The carbon clearance assay was determined using carbon ink. Sheep red blood cell was used as an antigen for other tests. Results Essential oils of A. abyssinica and L. sativum at 400 mg/kg significantly increased the rate of carbon clearance from the body of mice ( p <0.05). The maximum carbon clearance rate was achieved for A. byssinica essential oil at 400 mg/kg. Both essential oils raised the level of HAT to SRBC in comparison to the vehicle and cyclophosphamide administered groups. The largest (84.668±1.951) mean secondary HAT to SRBC was generated by L. sativum essential oil at 400 mg/kg ( p <0.001). A. abyssinica essential oil at 200 and 400 mg/kg significantly increased the level of thymus index compared to the model group ( p <0.05 and 0.01 respectively). The levamisole group experienced the highest increase in thymus index ( p <0.001). Essential oil of L. sativum at 400 mg/kg also increased the level of thymus index. The spleen index in mice was improved by the essential oils only at the highest dose levels (400 mg/kg). Conclusion It can be inferred that the essential oils of L. sativum and A. abyssinica have immunostimulant properties.

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“…Reduced glutathione (GSH) concentration was performed according to Sakhri et al (2021) method. First 800 μL of the liver homogenate was added to 200 μL of the sulfosalicylic acid (0.25%) solution, and then the mixture was incubated in an ice bath for 15 min.…”

Section: Gsh Measurementmentioning

confidence: 99%

The Antioxidant Activity and the Anti-inflammatory Effect of Citrus sinensis L. Fruit on Intestinal Inflammation Induced by Hyperhomocysteinemia in Mice

Khelfi¹,

Zerizer²,

Tebibel³

et al. 2023

NLSC

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Hyperhomocysteinemia is considered to be one of the risk factors for inflammatory bowel disease (IBD), it is a chronic, relapsing, and remittent inflammatory disease of the gastrointestinal tract. Citrus sinensis L. has been used traditionally to treat bowel disorders. The present study aims to quantify the phenolic and flavonoid contents of the Citrus sinensis L. fruit (ORF) extract and to evaluate in vitro the antioxidant activity and the anti-inflammatory effect of ORF in vivo on intestinal inflammation induced by hyperhomocysteinemia. The total phenolic and flavonoid contents of the extract were determinated using the spectrophotometric method and the evaluation of antioxidant activity was performed by four methods: DPPH, ABTS, CUPRAC, and reducing power. The inflammatory marker (plasma homocysteine), the reduced glutathione (GSH) content in the liver tissue were measured and the histological sections of the intestines of the mice used were examined to assess the anti-inflammatory activity of ORF. The results of this study showed that the ethanolic extract of ORF possessed high phenolic content and exhibited good antioxidant activity. The use of ORF powder in the in vivo study showed an increase in GSH levels, a decrease in plasma homocysteine levels, and a restoration of the integrity of the intestinal epithelium. Keywords: Hyperhomocysteinemia, Intestinal Inflammation, Citrus sinensis L. fruit, Antioxidant activity, Anti-inflammatory

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Evaluation of The Antioxidant, Antidiabetic and Immunomodulatory Activity of Cydonia oblonga Fruit Extract

Cited by 3 publications

References 34 publications

In vitro and in vivo bioactivities of Ambrosia maritima and Bituminaria bituminosa organic extracts from Algeria

In vitro and in vivo bioactivities of Ambrosia maritima and Bituminaria bituminosa organic extracts from Algeria

In-vivo Immunomodulatory Activities of Essential Oils of Artemisia abyssinica and Lepidium sativum in Mice

The Antioxidant Activity and the Anti-inflammatory Effect of Citrus sinensis L. Fruit on Intestinal Inflammation Induced by Hyperhomocysteinemia in Mice

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