Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol

Moura, Danielle Feijó de; Rocha, Tamiris Alves; Barros, Dayane de Melo; Silva, Marllyn Marques da; Santana, Marcielle dos Santos; Neta, Beatriz Mendes; Cavalcanti, Isabella Macário Ferro; Martins, René Duarte

doi:10.1007/s00203-021-02377-5

Cited by 19 publications

(11 citation statements)

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“…Moura et al tested nerolidol against selected ATCC strains of microorganisms in the concentration range from 0.25 to 4 mgmL -1 . Nerolidol inhibited the growth of S. aureus (MIC = 1 mgmL -1 ) and P. aeruginosa (MIC = 0.5 mgmL -1 ), whereas it showed no activity against the Gram-negative bacteria E. coli ATCC [15].…”

Section: Results Of Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of Essential Oil From the Aerial Parts of Pulicaria Dysenterica (L.) Bernh. (Asteraceae)

Cilović Kozarević,

Dautović,

Halilčević

et al. 2024

Technol. acta

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The chemical composition of Pulicaria dysenterica(L.) Bernh. aerial parts essential oil (EO), growing wildin Bosnia and Herzegovina, was presented in the study. In addition to the EO composition, antimicrobial and cytotoxic activities were also tested. The aerial parts of P. dysentericacontained 0.3% of yellow, liquid, fragrant EO. The 51 components identified accounted for 81.09% of the oil. The EO was characterized by the presence of a high concentration of oxygenated sesquiterpenes 51.83% while oxygenated monoterpenes constituted 15.57%, sesquiterpene hydrocarbons 9.32% and non-terpene compounds presented 4.37% of the EO. The dominant compounds were the sesquiterpenes caryophyllene oxide, (E)-nerolidol, β-caryophyllene and monoterpene nerol. The antimicrobial activity of EO was tested against selected ATCC strains of microorganisms, the bacteria Staphylococcus aureus, Pseudomonas aeruginosaand Escherichia coli, and the fungus Candida albicans. The results showed that the investigated EO inhibited the growth of all selected ATCC strains of microorganisms. The best result was obtained against Escherichia colibacteria with MIC value of 1 mgmL-1. The cytotoxicity of EO was measured against the HeLa cell line using the MTT method with IC50of 188.52 μgmL-1.This study has provided scientific baseline data on the therapeutic properties of P. dysenterica. KEYWORDS:Pulicaria dysenterica, essential oil,antimicrobial activity,citotoxicity

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Section: Results Of Antimicrobial Activitymentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of Essential Oil From the Aerial Parts of Pulicaria Dysenterica (L.) Bernh. (Asteraceae)

Cilović Kozarević,

Dautović,

Halilčević

et al. 2024

Technol. acta

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“…SEM images ( Fig 5 ) illustrated the reduction in bacterial cell aggregation on the glass surface in the presence of PGME. GC/MS analysis further identified several bioactive compounds in the active fraction of Psidium guajava , such as caryophyllene, alpha-copaene, and erolidol, known for their antibiofilm properties [ 45 , 46 ]. Quercetin also detected in PGME, has been previously reported to possess potent antibiofilm activity against pathogenic bacteria [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Antibiofilm and anti-quorum sensing activity of Psidium guajava L. leaf extract: In vitro and in silico approach

Khan,

Celik,

Khan

et al. 2023

PLoS ONE

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The quorum sensing mechanism relies on the detection and response to chemical signals, termed autoinducers, which regulate the synthesis of virulence factors including toxins, enzymes, and biofilms. Emerging therapeutic strategies for infection control encompass approaches that attenuate quorum-sensing systems. In this study, we evaluated the antibacterial, anti-quorum sensing, and anti-biofilm activities of Psidium guajava L. methanolic leaf extracts (PGME). Minimum Inhibitory Concentrations (MICs) of PGME were determined as 500 μg/ml for C. violaceum and 1000 μg/ml for P. aeruginosa PAO1. Significantly, even at sub-MIC concentrations, PGME exhibited noteworthy anti-quorum sensing properties, as evidenced by concentration-dependent inhibition of pigment production in C. violaceum 12742. Furthermore, PGME effectively suppressed quorum-sensing controlled virulence factors in P. aeruginosa PAO1, including biofilm formation, pyoverdin, pyocyanin, and rhamnolipid production, with concentration-dependent inhibitory effects. Phytochemical analysis utilizing GC-MS revealed the presence of compounds such as alpha-copaene, caryophyllene, and nerolidol. In-silico docking studies indicated a plausible mechanism for the observed anti-quorum sensing activity, involving favorable binding and interactions with QS-receptors, including RhlR, CviR’, LasI, and LasR proteins. These interactions were found to potentially disrupt QS pathways through suppression of AHL production and receptor protein blockade. Collectively, our findings propose PGME as a promising candidate for the treatment of bacterial infections. Its attributes that mitigate biofilm development and impede quorum-sensing mechanisms highlight its potential therapeutic value.

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“…Aromatic acids such as 3-HBA inhibit S. aureus biofilm activity targeting the Agr and SarA systems [ 119 ]. Nerolidol, a sesquiterpene, was found to inhibit S. aureus biofilm by > 70 % at concentrations ranging from 1 to 4 mg/mL [ 131 ].…”

Section: Emerging Natural Products-based Therapeutics Against ...mentioning

confidence: 99%

Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics

Wu,

Wang,

Xiong

et al. 2024

Biofilm

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Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol

Cited by 19 publications

References 50 publications

Antimicrobial and Cytotoxic Activities of Essential Oil From the Aerial Parts of Pulicaria Dysenterica (L.) Bernh. (Asteraceae)

Antimicrobial and Cytotoxic Activities of Essential Oil From the Aerial Parts of Pulicaria Dysenterica (L.) Bernh. (Asteraceae)

Antibiofilm and anti-quorum sensing activity of Psidium guajava L. leaf extract: In vitro and in silico approach

Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics

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