Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats

Ali, Taskina; Javan, Mohammad; Sonboli, Ali; Semnanian, Saeed

doi:10.1186/2008-2231-20-48

Cited by 35 publications

(20 citation statements)

References 19 publications

(16 reference statements)

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“…The essential oil analysis of N. pogonosperma proved that one isomer of Nepetalalactone,existed in essential oil that constituted 6.20% of the oil. Likewise, Ali et al (2012) founded 4aα, 7α, 7aα-nepetalactone (14.5%) as one of the main compounds in the oil of N. Pogonosperma. Our results are relatively in agreement with this research.…”

Section: Discussionmentioning

confidence: 99%

Biological activity of some essential oil constituents in four Nepeta L. species against Sitophilus oryzae L.

et al. 2019

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Amini S, Nohooji MG, Khani M, Labbafi MR, Khalighi-Sigaroodi f. 2019. Biological activity of some essential oil constituents in four Nepeta L. species against Sitophilus oryzae L.. Biodiversitas 20: 338-343. Recently, there has been a growing interest in research concerning the possible use of plant extracts as alternatives to synthetic insecticides. Essential oils are among the best-known natural substances with insecticidal properties. These compounds may act as fumigants, contact insecticides, repellents, antifeedants and may affect growth and development of the insects. In an attempt to find a natural and inexpensive method for the control of stored-product pests, contact toxicity of essential oils of Nepeta cataria, Nepeta pogonosperma, Nepeta glomerulosa. and Nepeta binaloudensis. were investigated on adult insects of Sitophilus oryzae L. (Coleoptera, Curculionidae) in vitro condition. Chemical Composition, repellency and fumigant toxicity of the essential oils were investigated. Chemical composition of the essential oils of above plants were identified by GC-MS. 4aα,7α,7aβ-nepetalactone (82.74 %) was major component of N. cataria and also different isomers of nepetalactone were among the major compounds in N. Pogonosperma and N. binaloudensis oils. In fumigants bioassay, N. glomerulosa (124.318μL/L air) showed the highest toxicity against S. oryzae adults, followed by N.pogonosperma (150.49μL/L air) and N. cataria (152.630μL/L air), respectively. Also, the S. oryzae was repelled by N. cataria (91.61%) and N. binaloudensis (91.50 %), respectively.

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Section: Discussionmentioning

confidence: 99%

Biological activity of some essential oil constituents in four Nepeta L. species against Sitophilus oryzae L.

et al. 2019

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“…Procurement and maintenance of animals Twenty (20) healthy adult Long Evans rats weighing 180 to 250 gm 14 of both sexes 24,27,28 were obtained from animal house of Bangladesh University of Health Sciences (BUHS), Dhaka. All the rats were kept in the Pain Laboratory of the Department of Physiology, BSMMU, where they were housed in specially built plastic cages with 6 rats per cage under a 12/12 hour light/dark cycle [29][30][31] . The ambient room temperature was maintained at around 27 to 28°C, corresponding to the thermo-neutral zone for rodents 17,32 .…”

Section: Methodsmentioning

confidence: 99%

Vitamin B12 and ketorolac on pain in Long Evans rats

Rahman¹,

Begum

Ali

et al. 2016

J Bangladesh Soc Physiol

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Background: Effects of vitamin B12 on pain have been demonstrated in different animal and human studies. But comparison of these effects with similar effects of ketorolac tromethamine (KT) and their combination have not been established.Objective: To assess the effects of vitamin B12 on pain and also to compare them with those of the combinations of vitamin B12 with KT in rat models.Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2015 to February 2016. For this, 20 (twenty) Long Evans rats (215±35 gm) of both sexes were divided into control (A, with 5 ml/kg normal saline) and experimental (B1, with 15 mg/kg B12; B2, with 10 mg/kg KT; B3, with B12+KT) groups with 5 rats in each group. All the drugs and vitamin were administered intraperitoneally in a single dose just one hour before formalin test. To evaluate the treatments effect on nociceptive pain, early phase (1st- 5th minutes); on central analgesic system, interphase (6th-15th minutes); and on inflammatory pain, late phase (16th-60th minutes) of the formalin test, were observed. In all phases, total frequency of jerking and total duration of flexing and licking of the right hind paw were counted after administration of subcutaneous formalin (50 ?l, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni post hoc test. In the interpretation of results, p?0.05 was considered as significant.Results: B12 lowered only the jerking frequency and KT lowered both jerking frequency and flexinglicking duration significantly (p?0.001) in the late phase of formalin test. On the other hand, combination of B12 and KT significantly (p?0.001) lowered both the study variables in all 3 phases of formalin test.Conclusion: From this study it may be concluded that, vitamin B12 possess analgesic effects and combination of B12 with KT is more effective than those of their individual administration.Bangladesh Soc Physiol. 2016, December; 11(2): 63-69

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“…They were housed in Pain Laboratory of the department of Physiology, BSMMU, in specially built plastic cages with 5 rats per cage under a 12/12 hour light/dark cycle [17][18][19] . The ambient room temperature was maintained at around 27-28 °C, corresponding to the thermoneutral zone for rodents [20][21] .…”

Section: Procurement and Maintenance Of Animalsmentioning

confidence: 99%

Erratum: Effect of Nigella sativa (Kalozira) oil on pain in Long Evans rats. J Bangladesh Soc Physiol 2018, June;13(1):1-7

Jerin¹,

Begum

2018

J Bangladesh Soc Physiol

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The author of this article brought attention to publishers that there were errors on page 1,3,4,5 published in previous issue. These errors have been corrected to enhance credibility to readers and the whole corrected article has been published in this issue of JBSP. The online version of the original article can be found at doi:http:/ /dx.doi.org/10.3329/jbsp,v13i1.37840(http://banglajol.info/ index.php/JBSP/article/view/37840) Background: For thousands of years, Nigella sativa has been used in many countries as a spice as well as a protective and curative remedy for numerous health disorders. Nigella sativa oil (NSO) suppressed pain in animal models. Objective: To assess the effects of Nigella sativa oil on pain after single administration with three increasing doses in rat models. Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2016 to February 2017. For this, 20 (twenty) Long Evans rats (200±20) of both sexes were divided into control ( 10 ml/kg of 1% solution of Tween 20) and experimental groups (NSO 0.5, with 0.5 ml/kg NSO; NSO 1, with 1 ml/kg NSO; NSO 1.5, with 1.5 ml/kg NSO) with 5 rats in each group. To assess nociceptive pain, central analgesic system and inflammatory pain early phase (1st-5th minutes); inter phase (6th-15th minutes) and late phase (16th-60th minutes) of formalin test respectively were observed. All the agents were given intraperitoneally in a single dose just one hour before the formalin test. In all phases, total frequency of jerking and total duration of flexing and licking of right hind paw were counted after administration of subcutaneous formalin (50 mL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni’s post hoc test. Results: In early phase, NSO significantly reduced the jerking (p ≤0.001, in all doses) and flexing and licking (p ≤0.001, in higher 2 doses). In interphase, jerking was significantly (p ≤0.01) lowered after 1.5 ml/kg of NSO but flexing and licking significantly lowered by all 3 doses (p ≤0.05, p ≤ 0.001, p≤ 0.001). In addition, in late phase jerking and flexing and licking was reduced by higher 2 doses (p ≤0.001) and all 3 doses respectively (p ≤ 0.001, in all doses). Conclusion: From this study, it may be concluded that, NSO possess analgesic effect and higher two doses were more effective than lower doses. J Bangladesh Soc Physiol. 2018, December; 13(2): 84-90

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Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats

Cited by 35 publications

References 19 publications

Biological activity of some essential oil constituents in four Nepeta L. species against Sitophilus oryzae L.

Biological activity of some essential oil constituents in four Nepeta L. species against Sitophilus oryzae L.

Vitamin B12 and ketorolac on pain in Long Evans rats

Erratum: Effect of Nigella sativa (Kalozira) oil on pain in Long Evans rats. J Bangladesh Soc Physiol 2018, June;13(1):1-7

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