Evaluation of the antimutagenic and antiradical potentials of extracts from the tubers of (Tunisian)<i>Cyperus rotundus</i>

Kilani, Soumaya; Bouhlel, Inès; Ben, Ribai; Abdelwahed, A.; Hayder, Nawel; Mahmoud, Amor; Ghedira, Kamel; Chekir-Ghedira, Pr. Leila

doi:10.1080/02772240500286194

Cited by 17 publications

(6 citation statements)

References 23 publications

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“…Furthermore, after 24 h exposure to DGQA, an apparent decrease in DNA damage induced by H 2 O 2 was observed. This is in accordance with antimutagenic activity of tannins reported previously (Abdelwahed et al ., ; Kilani et al ., ).…”

Section: Discussionmentioning

confidence: 99%

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂

Skandrani

Bouhlel

Bhouri

et al. 2011

J of Applied Toxicology

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3,5-O-di-galloylquinic acid (DGQA) purified from leaves of Myrtus communis was investigated for its antioxidative, antiproliferative and antigenotoxic activities. Antioxidant activity was determined by the ability of the compound to inhibit lipid peroxidation induced by H(2)O(2) in the K562 cell line. The pure molecule displayed an important malondialdehyde formation inhibition percentage (82.2%). Moreover, this compound exhibited an inhibitory effect against H(2)O(2)-induced genotoxicity, using the comet assay. A protective effect of the same molecule was also revealed when assessing the gene expression of the chronic myelogenous leukemia cell line (K562), stressed with H(2)O(2). For this purpose, we used a cDNA-microarray containing 82 genes related to cell defense, essentially represented by antioxidant and DNA repair proteins. We found that DGQA increase the activity of antioxidant enzymes family and the activity of DNA repair enzymes. Taken together, these observations provide evidence that the DGQA is able to protect cells against oxidative stress.

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Section: Discussionmentioning

confidence: 99%

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂

Skandrani

Bouhlel

Bhouri

et al. 2011

J of Applied Toxicology

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“…Phenolic compounds, such as flavonoids, phenolic acids, coumarins and tannins are secondary plant metabolites, and an important part of both human and animal diets [4,5]. They exert a wide variety of biological effects, including anticarcinogenic, antimutagenic and antioxidative activities [6,7,8,9]. The antioxidant activity of these compounds is mainly due to their redox properties, which allow them to act as reducing agents or hydrogen-atom donors [10].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

et al. 2012

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Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H 2 O 2 in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. We found a differential response among the compounds tested, with the ethyl acetate fraction being more effective than the crude extract, a difference perhaps related to the presence of the antioxidants identified and quantified by HPLC/DAD. In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide.

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“…6,71,95,96 Also, a majority of researchers have reported in vitro bioactivities and GC-MS analysis of crude extracts of this weed. 2,14,41,[97][98][99][100][101][102][103][104][105][106][107][108][109][110][111] The objective of the present review was to provide an update of NPs derived from this plant species, their bioactivity and the mechanism of actions of some of the compounds from published data in literature.…”

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confidence: 99%

Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

et al. 2021

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Evaluation of the antimutagenic and antiradical potentials of extracts from the tubers of (Tunisian)Cyperus rotundus

Cited by 17 publications

References 23 publications

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂

Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

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Evaluation of the antimutagenic and antiradical potentials of extracts from the tubers of (Tunisian)Cyperus rotundus

Cited by 17 publications

References 23 publications

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2

Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

Natural products in Cyperus rotundus L. (Cyperaceae): an update of the chemistry and pharmacological activities

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In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂

In vitro antioxidant and antigenotoxic potentials of 3,5‐O‐di‐galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H₂O₂