Evaluation of the antimicrobial property of green tea extract and its synergistic effect on antimicrobials showing resistance in clinical isolates of a tertiary care hospital

Chaturvedi, Vidushi; Kaore, Shilpa N.; Kaore, Navinchandra M.; Kaur, Surender; Gautam, Shantaram K

doi:10.4103/jmgims.jmgims_56_18

Cited by 5 publications

(1 citation statement)

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“…In South Korea and India, S. bigelovii is often used to treat obesity, diabetes, scabies, gastrointestinal imbalances, and other diseases. Research has demonstrated that various active ingredients such as flavonoids, alkaloids, polysaccharides, and saponins can be isolated from S. bigelovii and exert anti-inflammatory [ 3 ], antioxidant [ 4 ], antitumor [ 5 ], hypoglycemic, and lipid-lowering effects [ 6 ]. Research has confirmed that S. bigelovii possesses a high content of flavonoids [ 7 ], alkaloids, chromones [ 8 ], and sterols [ 9 ], and Quercetin and Quercetin-3-O have also been isolated from S. bigelovii along with β-D-glucoside, Rutin, and Isorhamnol-3-O-β-flavonoids such as D-glucoside.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Process of Total Flavonoids from Salicornia bigelovii Torr. and Its Hepatoprotective Effect on Alcoholic Liver Injury Mice

Wang,

Lv,

et al. 2024

Foods

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The objective of this study was to determine the optimal extraction conditions for total flavonoids from S. bigelovii using microwave-assisted extraction and to analyze the protective effect of total flavonoids from S. bigelovii on alcoholic liver injury in mice. The optimization of the process conditions for the microwave-assisted extraction of total flavonoids from S. bigelovii was performed using response surface methodology, and an alcohol-induced acute liver injury model in mice was used to investigate the effects of different doses of total flavonoids (100 mg/kg, 200 mg/kg, and 400 mg/kg) on the levels and activities of serum alanine aminotransferase kits (ALT), glutamic oxaloacetic transaminase kits (AST), superoxide dismutase kits (SOD), glutathione peroxidase kits (GSH-Px), and malondialdehyde (MDA). We performed hematoxylin–eosin (H&E) staining analysis on pathological sections of mouse liver tissue, and qRT-PCR technology was used to detect the expression levels of the inflammatory factors IL-1 β, IL-6, and TNF-α. The results revealed that the optimal extraction process conditions for total flavonoids in S. bigelovii were a material-to-liquid ratio of 1:30 (g/mL), an ethanol concentration of 60%, an extraction temperature of 50 °C, an ultrasound power of 250 W, and a yield of 5.71 ± 0.28 mg/g. Previous studies have demonstrated that the flavonoids of S. bigelovii can significantly inhibit the levels of ALT and AST in the serum (p < 0.001), reduce MDA levels (p < 0.001), increase the activity of the antioxidant enzymes SOD and GSH-Px (p < 0.001), and inhibit the IL-1 β, IL-6, and TNF-α gene expression levels (p < 0.001) of inflammatory factors. The total flavonoids of S. bigelovii exert a protective effect against alcoholic liver injury by reducing the levels of inflammation, oxidative stress, and lipid peroxidation caused by alcohol. The results of this study lay the foundation for the high-value utilization of S. bigelovii and provide new resources for the development of liver-protective drugs.

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Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Process of Total Flavonoids from Salicornia bigelovii Torr. and Its Hepatoprotective Effect on Alcoholic Liver Injury Mice

Wang,

Lv,

et al. 2024

Foods

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In vitro screening and characterization of phytochemical products from Alstonia scholaris (Linn) and its bioactive potential for sustainable application

Santhose,

Adhikary,

Bharathi

et al. 2023

Biomass Conv. Bioref.

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The chemical composition analysis of dwarf saltwort ( Salicornia bigelovii Torr.) and its preservative effects on snakehead fish fillets

Wang

Dong

et al. 2022

Food Processing Preservation

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In this study, the nutritional component and chemical constituents of Salicornia bigelovii Torr. were investigated, as well as their preservative effects on aquatic products. LC–MS of S. bigelovii extracts detected 34 compounds, eight flavonoids were identified based on standard substance. Camellianin A and noreugenin were identified for the first time in S. bigelovii. Furthermore, the S. bigelovii could reduce the fish fillet loss rate and inhibit the growth of microorganisms in aquatic products that impact cooking loss rate, pH, total volatile basic nitrogen, total viable count, and it also could reduce the damage of myofibrillar proteins texture changes. Finally, the S. bigelovii had a strong inhibitory effect on the dominant spoilage bacteria Pseudomonas in snakehead fish was demonstrated, and significantly prolong the preservation time of fish fillet till the 12 days. Overall, this study provides a basis for the selection of suitable methods for the preservation and processing of aquatic products. Novelty impact statement The Salicornia bigelovii was found a strong inhibitory effect on the bacteria Pseudomonas in snakehead fish, and it can significantly prolong the preservation time of fish fillet, which were expected to be used as the selection of suitable methods for the preservation and processing of aquatic products.

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Evaluation of the antimicrobial property of green tea extract and its synergistic effect on antimicrobials showing resistance in clinical isolates of a tertiary care hospital

Cited by 5 publications

References 0 publications

Optimization of Microwave-Assisted Extraction Process of Total Flavonoids from Salicornia bigelovii Torr. and Its Hepatoprotective Effect on Alcoholic Liver Injury Mice

Optimization of Microwave-Assisted Extraction Process of Total Flavonoids from Salicornia bigelovii Torr. and Its Hepatoprotective Effect on Alcoholic Liver Injury Mice

In vitro screening and characterization of phytochemical products from Alstonia scholaris (Linn) and its bioactive potential for sustainable application

The chemical composition analysis of dwarf saltwort ( Salicornia bigelovii Torr.) and its preservative effects on snakehead fish fillets

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