Evaluation of the Antimicrobial Effects of Several Isothiocyanates on<i>Helicobacter pylori</i>

Haristoy, X.; Fahey, Jed W.; Scholtus, Isabelle; Lozniewski, Alain

doi:10.1055/s-2005-864098

Cited by 91 publications

(65 citation statements)

References 17 publications

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“…These compounds also have the potential to control agricultural and public health insect pests (Tsao et al, 1996). For example, Helicobacter pylori bacterium was found to be highly susceptible to 4-(a-L-rhamnopyranosyloxy) benzyl isothiocyanate and various other isothiocyanates, which are degraded products of glucosinolates Haristoy et al, 2005). H. pylori is a major cause of gastric and duodenal ulcers, and is a major risk factor for gastric cancer.…”

Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

370

214

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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. As a result of this, scientists have intensified efforts in exploiting plants, plant extracts or natural plant compounds as potential natural alternatives for enhancing the livestock productivity. This paper discusses work on the effects of various phytochemicals and plant secondary metabolites in ruminant and fish species. The focus is on (i) plants such as Ananas comosus (pine apple), Momordica charantia (bitter gourd) and Azadirachta indica (neem) containing anthelmintic compounds and for their use for controlling internal parasites; (ii) plants containing polyphenols and their applications for protecting proteins from degradation in the rumen, increasing efficiency of microbial protein synthesis in rumen and decreasing methane emission; for using as antioxidants, antibacterial and antihelmintic agents; and for changing meat colour and for increasing n-3 fatty acids and conjugated linoleic acid in meat; (iii) saponin-rich plants such as quillaja, yucca and Sapindus saponaria for increasing the efficiency of rumen fermentation, decreasing methane emission and enhancing growth; for producing desired nutritional attributes such as lowering of cholesterol in monogastric animals; for increasing growth of fish (common carp and Nile tilapia) and for changing male to female ratio in tilapia; and for use as molluscicidal agents; (iv) Moringa oleifera leaves as a source of plant growth factor(s), antioxidants, beta-carotene, vitamin C, and various glucosinolates and their degraded products for possible use as antibacterial, antioxidant, anticarcinogenic and antipest agents; (v) Jatropha curcas toxic variety with high levels of various phytochemicals such as trypsin inhibitor, lectin, phytate and phorbol esters in seeds limiting the use of seed meal in fish and livestock diets; and the use of phorbol esters as bio-pesticidal agent; and (vi) lesser-known legumes such as Entada phaseoloides seeds containing high levels of trypsin inhibitor and saponins, Sesbania aculeate seeds rich in non-starch polysaccharides and Mucuna pruriens var. utilis seeds rich in L-3,4-dihydroxyphenylalanine and their potential as fish feed; Cassia fistula seeds as a source of antioxidants; and the use of Canavalia ensiformis, C. gladiata and C. virosa seeds containing high levels of trypsin inhinitor, lectins and canavanine. The paper also presents some challenges and future areas of work in this field.

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Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

370

214

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“…It is also a selective and highly potent antimicrobial agent against H. pylori in vitro and it prevents development of chemically induced stomach tumors in a rodent model (11). Several studies have confirmed the anti-H. pylori activity of sulforaphane (12,13), and an early attempt to evaluate its efficacy in vivo with only one biomarker of efficacy has identified some of the issues that would be likely to occur in a trial in which complete eradication of H. pylori is not required as an end point (14). A subsequent pilot study in Detroit reported eradication of infection in three of nine H. pylori-infected patients (15).…”

mentioning

confidence: 93%

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis inHelicobacter pylori–Infected Mice and Humans

Yanaka

Fahey

Fukumoto

et al. 2009

Cancer Prevention Research

Self Cite

236

178

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The isothiocyanate sulforaphane [SF; 1-isothiocyanato-4(R)-methylsulfinylbutane] is abundant in broccoli sprouts in the form of its glucosinolate precursor (glucoraphanin). SF is powerfully bactericidal against Helicobacter pylori infections, which are strongly associated with the worldwide pandemic of gastric cancer. Oral treatment with SF-rich broccoli sprouts of C57BL/6 female mice infected with H. pylori Sydney strain 1 and maintained on a high-salt (7.5% NaCl) diet reduced gastric bacterial colonization, attenuated mucosal expression of tumor necrosis factor-α and interleukin-1β, mitigated corpus inflammation, and prevented expression of high salt-induced gastric corpus atrophy. This therapeutic effect was not observed in mice in which the nrf2 gene was deleted, strongly implicating the important role of Nrf2-dependent antioxidant and anti-inflammatory proteins in SF-dependent protection. Forty-eight H. pylori-infected patients were randomly assigned to feeding of broccoli sprouts (70 g/d; containing 420 μmol of SF precursor) for 8 weeks or to consumption of an equal weight of alfalfa sprouts (not containing SF) as placebo. Intervention with broccoli sprouts, but not with placebo, decreased the levels of urease measured by the urea breath test and H. pylori stool antigen (both biomarkers of H. pylori colonization) and serum pepsinogens I and II (biomarkers of gastric inflammation). Values recovered to their original levels 2 months after treatment was discontinued. Daily intake of sulforaphane-rich broccoli sprouts for 2 months reduces H. pylori colonization in mice and improves the sequelae of infection in infected mice and in humans. This treatment seems to enhance chemoprotection of the gastric mucosa against H. pylori-induced oxidative stress.

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“…Sulforaphane is a plant secondary metabolite that is synthesized from glucosinolates after damage to the plant, presumably to protect from microbial infestation. It has demonstrated antimicrobial efficacy against Helicobacter pylori (13,16,17) and in another study 23 of 28 tested microbes (25). The chemical is therefore likely exhibiting a hormesis effect by inducing Nrf2 (43).…”

Section: Modulating the Nrf2 Pathwaymentioning

confidence: 99%

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

Calkins

Johnson

Townsend

et al. 2009

Antioxidants & Redox Signaling

396

302

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Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor known to induce expression of a variety of cytoprotective and detoxification genes. Several of the genes commonly regulated by Nrf2 have been implicated in protection from neurodegenerative conditions. Work from several laboratories has uncovered the potential for Nrf2-mediated transcription to protect from neurodegeneration resulting from mechanisms involving oxidative stress. For this reason, Nrf2 may be considered a therapeutic target for conditions that are known to involve free radical damage. Because common mechanisms of neurodegeneration, such as mitochondrial dysfunction and build-up of reactive oxygen species, are currently being uncovered, targeting Nrf2 may be valuable in combating conditions with variable causes and etiologies. Most effectively to target this protein in neurodegenerative conditions, a description of the involvement of Nrf2 and potential for neuroprotection must come from laboratory models. Herein, we review the current literature that suggests that Nrf2 may be a valuable therapeutic target for neurodegenerative disease, as well as experiments that illustrate potential mechanisms of protection. Antioxid. Redox Signal. 11,[497][498][499][500][501][502][503][504][505][506][507][508]

show abstract

Evaluation of the Antimicrobial Effects of Several Isothiocyanates onHelicobacter pylori

Cited by 91 publications

References 17 publications

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis inHelicobacter pylori–Infected Mice and Humans

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

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